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anti-Human OGG1 Antibodies:
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Human Polyclonal OGG1 Primary Antibody for ELISA, FACS - ABIN151034
Mambo, Nyaga, Bohr, Evans: Defective repair of 8-hydroxyguanine in mitochondria of MCF-7 and MDA-MB-468 human breast cancer cell lines. in Cancer research 2002
Show all 85 Pubmed References
Human Polyclonal OGG1 Primary Antibody for ELISA, ICC - ABIN314155
Roseborough, Gao, Chen, Trush, Zhou, Williams, Wei: The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord. in The American journal of pathology 2006
Show all 15 Pubmed References
Human Polyclonal OGG1 Primary Antibody for ELISA, IHC - ABIN314156
Xydas, Kherani, Chang, Klotz, Hay, Mutrie, Moss, Gu, Schulman, Gao, Hu, Wu, Wei, Oz, Wang: beta(2)-Adrenergic stimulation attenuates left ventricular remodeling, decreases apoptosis, and improves calcium homeostasis in a rodent model of ischemic cardiomyopathy. in The Journal of pharmacology and experimental therapeutics 2006
Show all 15 Pubmed References
Human Polyclonal OGG1 Primary Antibody for IHC - ABIN966715
Aburatani, Hippo, Ishida, Takashima, Matsuba, Kodama, Takao, Yasui, Yamamoto, Asano: Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. in Cancer research 1997
Show all 5 Pubmed References
Human Polyclonal OGG1 Primary Antibody for IHC - ABIN966716
Rosenquist, Zharkov, Grollman: Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. in Proceedings of the National Academy of Sciences of the United States of America 1997
Show all 5 Pubmed References
Human Polyclonal OGG1 Primary Antibody for IF (p), IHC (p) - ABIN702655
Cogoi, Ferino, Miglietta, Pedersen, Xodo: The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription. in Nucleic acids research 2017
Rat (Rattus) Polyclonal OGG1 Primary Antibody for ELISA, WB - ABIN253303
Kovtun, Liu, Bjoras, Klungland, Wilson, McMurray: OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. in Nature 2007
Human Polyclonal OGG1 Primary Antibody for IHC, WB - ABIN5664036
Xu, Zhang, Zhang, Meng, Zhang, Jiang, Xu, Van Meter, Seluanov, Gorbunova, Mao: SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. in Cell cycle (Georgetown, Tex.) 2015
OGG1 activity might be inhibited during postreplicative mismatch repair.
Results show ogg1 is fundamentally required for protecting the developing brain, which may be helpful in understanding the aetiology of congenital brain deficits.
work demonstrates the requirement of ogg1 in cardiac progenitors and heart development in zebrafish
Arabidopsis cells use both FPG and OGG1 to repair 8-oxoG in a pathway that requires ZDP and ARP (show ARFRP1 Antibodies) in downstream steps.
Overexpression of OGG1 enhances seed longevity and abiotic stress tolerance.
HOGG1 Ser326Cys, APE1 (show APEX1 Antibodies) Asp148Glu and XRCC1 (show XRCC1 Antibodies) Arg399Gln polymorphisms are correlated with the risk and clinicopathological features of PACG.
The Gene expression levels of OGG1 was robustly elevated in oligodendrocytes laser captured from BA10 and amygdala white matter of Major Depressive Disorder.
The findings showed that hOGG1-Ser326Cys Cys (show DNAJC5 Antibodies) allele is statistically important and relevant with respect to the development of oral squamous cancer.
Overexpressed beta-OGG1 has the same role as alpha-OGG1 in protecting bronchial epithelial cells from apoptosis and mitochondrial dysfunction. Additionally, knocking down OGG1 enhanced oxidative damage-induced apoptosis and mitochondrial dysfunction. The antiapoptotic function of beta-OGG1 involved the JNK (show MAPK8 Antibodies) signaling pathway.
The rs2304277 variant in the OGG1 glycosidase gene associated to a significant OGG1 transcriptional down regulation independently of the BRCA mutational status and this variant may exert a synergistic effect together with BRCA1 or BRCA2 (show BRCA2 Antibodies) mutations in ovarian cancer
OGG1 can initiate BER at positions off the dyad axis and that this activity is facilitated by spontaneous and transient unwrapping of DNA from the histones. Local nuances in the nucleosome environment and histone-DNA interactions can impact glycosylase activity.
8-oxoguanine DNA glycosylase-1 (OGG1) is the essential protein involved in oxidative stress-induced (show SQSTM1 Antibodies) DNA demethylation.
The allele combination of CGC from hOGG1, ITGA2 (show ITGA2 Antibodies) and XPD (show ERCC2 Antibodies) polymorphisms was significantly associated with increased odds of nasopharyngeal carcinoma.
Increased oxidative DNA damage in primary open angle glaucoma may be attributed to decreased expression of DNA repair enzymes, OGG1 and PARP1 (show PARP1 Antibodies), of the base excision repair pathway.
Results show that some polymorphic variants in XRCC1 (show XRCC1 Antibodies) and OGG1 are associated with increased DNA damage in Alzheimer's Disease.
OGG1 plays a role in an LSD1 (show KDM1A Antibodies)-dependent pathway of LPS (show TLR4 Antibodies)-induced macrophage activation in mice.
These findings demonstrate that OGG-1 negatively regulates inflammatory cytokine release by coordinating molecular interaction with the autophagic pathway in hyperoxia-induced lung injury.
These results together, points to a new paradigm about the role of DNA damage and repair by OGG1 in aging and age-associated disease processes.
results implicate hyperglycemia-induced O-GlcNAcylation of Ogg1 in increased mtDNA damage and, therefore, provide a new plausible biochemical mechanism for diabetic cardiomyopathy.
DNA repair protein (show ATRIP Antibodies) OGG1 bound to its substrate is coupled to DNA occupancy of NF-kappaB (show NFKB1 Antibodies) and functions in epigenetic regulation of gene expression.
OGG1 plays a protective role in atherosclerosis by preventing excessive inflammasome activation.
OGG1 acts as a STAT1 (show STAT1 Antibodies) coactivator and has transcriptional activity in the presence of endotoxin
Ogg1 and Mutyh (show MUTYH Antibodies) regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior.
Data suggest that OGG1 plays a vital role in the protection of DNA bases from oxidative damage induced by radiofrequency electromagnetic radiation.
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
8-oxoguanine DNA glycosylase
, N-glycosylase/DNA lyase
, 8-OXOGUANINE DNA GLYCOSYLASE
, DNA-formamidopyrimidine glycosylase
, 8-oxoguanine-DNA glycosylase 1
, 8-oxoguanine DNA-glycosylase 1
, n-glycosylase/DNA lyase-like
, 8-hydroxyguanine DNA glycosylase
, AP lyase
, DNA-apurinic or apyrimidinic site lyase
, OGG1 type 1f