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anti-Human PALB2 Antibodies:
anti-Mouse (Murine) PALB2 Antibodies:
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Human Polyclonal PALB2 Primary Antibody for ICC, IF - ABIN253057
Brough, Bajrami, Vatcheva, Natrajan, Reis-Filho, Lord, Ashworth: APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer. in The EMBO journal 2012
Show all 2 Pubmed References
Human Polyclonal PALB2 Primary Antibody for IHC, IP - ABIN253058
Martrat, Maxwell, Tominaga, Porta-de-la-Riva, Bonifaci, Gómez-Baldó, Bogliolo, Lázaro, Blanco, Brunet, Aguilar, Fernández-Rodríguez, Seal, Renwick, Rahman, Kühl, Neveling, Schindler, Ramírez et al.: Exploring the link between MORF4L1 and risk of breast cancer. ... in Breast cancer research : BCR 2011
Our data presented the germline mutation status of PALB2 in Chinese breast cancer patients, suggesting that loss-of-function germline mutations of PALB2 are important in both familial and sporadic breast cancer. Clinically, these data may be helpful in genetic counseling of breast cancer patients with PALB2 germline mutation.
Truncating variants in PALB2, ATM and CHEK2 , but not XRCC2 were associated with increased breast cancer risk.
PALB2 associates with active genes through its major binding partner, MRG15 (show MORF4L1 Antibodies), which recognizes histone H3 (show HIST3H3 Antibodies) trimethylated at lysine 36 (H3K36me3) by the SETD2 (show SETD2 Antibodies) methyltransferase
the involvement of PALB2 mutations in the predisposition to cancer and the role of PALB2 in stimulating error-free DNA repair through the FA/HR pathway.
FANCD2 (show FANCD2 Antibodies) and PALB2, as indicators of the upstream and downstream arms, respectively, colocalize independently of each other in response to DNA damage.
The findings demonstrate that RNF168 couples PALB2-dependent homologous recombination to H2A ubiquitylation to promote DNA repair and preserve genome integrity.
The results of the present study suggest that mutations in the PALB2 gene may be particularly relevant to breast cancer susceptibility in the Jamaican population.
We identified two PALB2 mutations that are founder alleles in Italian families, one of which is, independently, also a founder mutation in American-Hispanic breast cancers.
Our results indicate that the PALB2 exon 13 duplication is a pathogenic variant. The presence of the PALB2 duplication in the proband affected with high-grade serous ovarian cancer suggests that PALB2 might be associated with a predisposition to ovarian cancer.
We showed that the mutation frequency of RAD51C (show RAD51C Antibodies) in Japanese familial breast cancer cases was similar to that in Western countries and that the prevalence of deleterious mutation of PALB2 was possibly lower. Furthermore, our results suggested that BRIP1 (show MRPL36 Antibodies) mutation frequency in Japan might differ from that in Western countries
we describe a genetic approach to examine the functional significance of the interaction between BRCA2 (show BRCA2 Antibodies) and PALB2 by generating a knock-in mouse model of Brca2 (show BRCA2 Antibodies) carrying a single amino acid change (Gly25Arg, Brca2G25R) that disrupts this interaction. In addition, we have combined Brca2G25R homozygosity as well as hemizygosity with Palb2 and Trp53 (show TP53 Antibodies) heterozygosity .
results underscore the in vivo importance of the PALB2-BRCA1 complex formation in DSB repair and male meiosis
Palb2 synergizes with Trp53 (show TP53 Antibodies) to suppress mammary tumor formation in a model of inherited breast cancer.
A key function for PALB2 is to interact with and to build up appropriate communication between BRCA1 (show BRCA1 Antibodies) and BRCA2 (show BRCA2 Antibodies).
This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.
partner and localizer of BRCA2
, Fanconi N
, Fanconi anemia
, complementation group N
, partner and localizer of BRCA2-like