PALB2 antibody (C-Term)

Catalog No. ABIN500447

There is 1 publication for this product available. The Rabbit Polyclonal anti-PALB2 antibody is suitable to detect PALB2 in samples from Human, Mouse and Rat. It has been validated for WB and EIA.

Quick Overview for PALB2 antibody (C-Term) (ABIN500447)

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PALB2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-PALB2 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects PALB2.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: PALB2 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human PALB2.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

References for anti-PALB2 antibody (ABIN500447)

Loke, Pearlman, Upadhyay, Tesfa, Shao, Ostrer: "Functional variant analyses (FVAs) predict pathogenicity in the BRCA1 DNA double-strand break repair pathway." in: Human molecular genetics, Vol. 24, Issue 11, pp. 3030-7, (2016) (PubMed).

Target Details for PALB2

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Alternative Name: PALB2

Background: The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.Synonyms: FANCN, Partner and localizer of BRCA2

Gene ID: 79728

UniProt: Q86YC2

Pathways: DNA Damage Repair