PALB2 antibody (C-Term)

Catalog No. ABIN6991161

Product Details anti-PALB2 Antibody

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Binding Specificity: AA 940-990, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PALB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: At least four isoforms of PALB2 are known to exist, this antibody will detect all four isoforms.

Purification: PALB2 Antibody is affinity chromatography purified via peptide column.

Immunogen: PALB2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human PALB2. The immunogen is located within amino acids 940 - 990 of PALB2.

Isotype: IgG

Application Details

Application Notes: PALB2 antibody can be used for detection of PALB2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PALB2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PALB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PALB2

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Alternative Name: PALB2 (PALB2 Products)

Synonyms: PALB2 antibody, Fancn antibody, si:ch211-14k19.9 antibody, FANCN antibody, PNCA3 antibody, 4732427B05 antibody, BC066140 antibody, RGD1304759 antibody, partner and localizer of BRCA2 antibody, partner and localizer of BRCA2 L homeolog antibody, PALB2 antibody, palb2 antibody, palb2.L antibody, Palb2 antibody

Background: PALB2 Antibody: The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments.

Molecular Weight: Predicted: 65, 100, 130 kDa

Observed: 140 kDa

Gene ID: 79728

UniProt: Q86YC2

Pathways: DNA Damage Repair