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Human Polyclonal PRKDC Primary Antibody for IHC - ABIN966894
Hartley, Gell, Smith, Zhang, Divecha, Connelly, Admon, Lees-Miller, Anderson, Jackson: DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. in Cell 1995
Show all 8 Pubmed References
Human Polyclonal PRKDC Primary Antibody for IHC - ABIN966893
Ladenburger, Fackelmayer, Hameister, Knippers: MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12-->q13. in Cytogenetics and cell genetics 1997
Show all 8 Pubmed References
Human Polyclonal PRKDC Primary Antibody for IP, ELISA - ABIN129603
Dittmann, Mayer, Wanner, Kehlbach, Rodemann: The radioprotector O-phospho-tyrosine stimulates DNA-repair via epidermal growth factor receptor- and DNA-dependent kinase phosphorylation. in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2007
Show all 5 Pubmed References
Human Polyclonal PRKDC Primary Antibody for IP, WB - ABIN152081
Hossain, Ji, Anish, Jacobson, Takada: Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation. in The Journal of biological chemistry 2009
Show all 3 Pubmed References
Human Monoclonal PRKDC Primary Antibody for ICC, IHC - ABIN969366
Durkin, Guo, Fryrear, Mihaylova, Gupta, Belgnaoui, Haoudi, Kupfer, Semmes: HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase. in The Journal of biological chemistry 2008
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Human Polyclonal PRKDC Primary Antibody for ELISA, FACS - ABIN4305546
Lorat, Schanz, Schuler, Wennemuth, Rübe, Rübe: Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy. in PLoS ONE 2012
Show all 2 Pubmed References
Hamster Polyclonal PRKDC Primary Antibody for GS, IP - ABIN2473350
Masuda: Letter: Elaboration on carbenicillin article. in American journal of hospital pharmacy 1975
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Human Polyclonal PRKDC Primary Antibody for IHC - ABIN966004
Ding, Reddy, Wang, Woods, Douglas, Ramsden, Lees-Miller, Meek: Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. in Molecular and cellular biology 2003
Human Monoclonal PRKDC Primary Antibody for IF, IHC (p) - ABIN519209
Berard, Coombs, Severini: Quantification of the host response proteome after herpes simplex virus type 1 infection. in Journal of proteome research 2015
Human Monoclonal PRKDC Primary Antibody for IF, IHC - ABIN269396
Shamanna, Hoque, Lewis-Antes, Azzam, Lagunoff, Peery, Mathews: The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining. in Molecular and cellular biology 2011
DNA-dependent protein kinase plays a central role in transformation of breast epithelial cells following alkylation damage.
miRNA-101 level is decreased in RCC (show XRCC1 Antibodies) tissues/cells, which could be responsible for DNA-PKcs overexpression and DNA-PKcs mediated oncogenic actions; DNA-PKcs over-expression regulates mTORC2 (show CRTC2 Antibodies)-AKT (show AKT1 Antibodies) activation, HIF-2alpha (show EPAS1 Antibodies) expression and RCC (show XRCC1 Antibodies) cell proliferation
The study reveals a structural basis for the complex assembly of DNA-PK and an allosteric mechanism for the activation of DNA-PKcs.
DNA-PK holoenzyme cryo-EM map reveals density for the C-terminal globular domain of Ku80 (show XRCC5 Antibodies) that interacts with the arm of DNA-PKcs
Data indicate that abnormal ERGIC1 (show ERGIC1 Antibodies) and DNA-PKcs expression may play an important role in gastric cancer initiation.
downregulation of PRKDC sensitized MCF-7 cells to chemo-drugs both in vitro and in a xenografted mouse model. Collectively, our study demonstrated that PRKDC is a prognostic biomarker for chemoresistance in breast cancer patients.
Down-regulation of PRKDC attenuates tumor progression in prostate cancer (PCa (show FLVCR1 Antibodies)). PRKDC may potentially be a prognostic biomarker in PCa (show FLVCR1 Antibodies).
Suggest that IL-10 (show IL10 Antibodies) rs1800871 and PRKDC rs7003908 may be useful biomarkers for predicting glioma patient survival.
Results provide evidence that DNA-PKcs is a primary resistance factor of salinomycin in osteosarcoma cells.
This study showed that the levels of CD44 (show CD44 Antibodies) and DNA-PK are associated with a better survival and better response to radiotherapy and temozolomide.
Ku80 (show XRCC5 Antibodies) is susceptible to proteolytic degradation when not dimerized with Ku70 (show XRCC6 Antibodies); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme
DNA repair, mediated by DNA-PK, and cell cycle arrest, mediated by p53 (show TP53 Antibodies), cooperate to protect the stem cell niche after DNA damage.
Decreasing DNA-dependent protein kinase (show CDK7 Antibodies) activity increases AMPK (show PRKAA1 Antibodies) activity and prevents weight gain, decline of mitochondrial function, and decline of physical fitness in middle-aged mice and protects against type 2 diabetes.
Ku70 is epistatic with XLF and DNA-PKcs and support a model in which inactivation of Ku70 allows DNA lesions to become accessible to alternative DNA repair pathways (other than Classical Non-Homologous End-Joining (C-NHEJ)).
DNA-PKcs deficiency caused inefficient DSB repair at later time points post-IR in both conditions. These observations suggest that DNA-PKcs contributes to the fast and slow repair of DSBs by NHEJ.
The SAGA deubiquitinase activity was required for optimal irradiation-induced gammaH2AX (show H2AFX Antibodies) formation, and failure to remove H2BK120ub inhibits ATM (show ATM Antibodies)- and DNAPK-induced gammaH2AX (show H2AFX Antibodies) formation.
functional DNA-PKcs T2609 cluster is required to facilitate telomere leading strand maturation and prevention of genomic instability and cancer development.
TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.
DNA-PKcs are required to prevent endogenous DNA damage accumulation throughout the adult brain.
AIM2 (show AIM2 Antibodies) reduced Akt (show AKT1 Antibodies) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 Antibodies) inhibitor reduced tumor load in Aim2 (show AIM2 Antibodies)(-/-) mice
PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (show TRIP13 Antibodies) binding partners in head and neck cancer.
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.
DNA-PK catalytic subunit
, DNA-dependent protein kinase catalytic subunit
, hyper-radiosensitivity of murine scid mutation, complementing 1
, protein kinase, DNA-activated, catalytic polypeptide
, protein kinase catalytic subunit (DNA-dependent protein kinase)
, DNA-activated protein kinase catalytic polypeptide
, DNA-dependent protein kinase catalytic subunit-like
, doxorubicin nephropathy
, severe combined immunodeficiency