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Human PRKDC Protein expressed in Wheat germ - ABIN1316293
Pyun, Seo, Lee, Jin, Kim, Kim, Kim, Nam, Yook, Lee: Mutual regulation between DNA-PKcs and Snail1 leads to increased genomic instability and aggressive tumor characteristics. in Cell death & disease 2013
downregulation of PRKDC sensitized MCF-7 cells to chemo-drugs both in vitro and in a xenografted mouse model. Collectively, our study demonstrated that PRKDC is a prognostic biomarker for chemoresistance in breast cancer patients.
Down-regulation of PRKDC attenuates tumor progression in prostate cancer (PCa (show FLVCR1 Proteins)). PRKDC may potentially be a prognostic biomarker in PCa (show FLVCR1 Proteins).
Suggest that IL-10 (show IL10 Proteins) rs1800871 and PRKDC rs7003908 may be useful biomarkers for predicting glioma patient survival.
Results provide evidence that DNA-PKcs is a primary resistance factor of salinomycin in osteosarcoma cells.
This study showed that the levels of CD44 (show CD44 Proteins) and DNA-PK are associated with a better survival and better response to radiotherapy and temozolomide.
this study suggests that improved anti-proliferative and cytotoxic effects of Ag-np treatment in cancer cells can be achieved by the inhibition of DNA-PKcs.
this study has solved the PRKDC structure in complex with the C-terminal peptide of Ku80 (show XRCC5 Proteins) at 4.3 angstrom resolution using x-ray crystallography.
DNA-PKcs, which is integral to the non-homologous end joining pathway, negatively regulates ATM (show ATM Proteins) activity through phosphorylation of ATM (show ATM Proteins).
that EZH2 (show EZH2 Proteins) is phosphorylated by the DNA damage responsive complex DNA-PK and regulates DNA damage-mediated T-cell apoptosis.
DNA-PKcs is a potent regulator of IL-2 (show IL2 Proteins) production in T lymphocytes.
Ku80 (show XRCC5 Proteins) is susceptible to proteolytic degradation when not dimerized with Ku70 (show XRCC6 Proteins); dimer induces DNA-PK activity; evidence that interacting domain(s) of Xenopus DNA-PKcs is conserved so as to interact with human Ku, reconstituting a functional holoenzyme
Decreasing DNA-dependent protein kinase (show CDK7 Proteins) activity increases AMPK (show PRKAA1 Proteins) activity and prevents weight gain, decline of mitochondrial function, and decline of physical fitness in middle-aged mice and protects against type 2 diabetes.
Ku70 is epistatic with XLF and DNA-PKcs and support a model in which inactivation of Ku70 allows DNA lesions to become accessible to alternative DNA repair pathways (other than Classical Non-Homologous End-Joining (C-NHEJ)).
DNA-PKcs deficiency caused inefficient DSB repair at later time points post-IR in both conditions. These observations suggest that DNA-PKcs contributes to the fast and slow repair of DSBs by NHEJ.
The SAGA deubiquitinase activity was required for optimal irradiation-induced gammaH2AX (show H2AFX Proteins) formation, and failure to remove H2BK120ub inhibits ATM (show ATM Proteins)- and DNAPK-induced gammaH2AX (show H2AFX Proteins) formation.
functional DNA-PKcs T2609 cluster is required to facilitate telomere leading strand maturation and prevention of genomic instability and cancer development.
TMU-35435 enhances etoposide cytotoxicity by regulating ubiquitin-proteasomal degradation of DNA-PKcs and inhibiting the DNA repair pathway in triple negative breast cancer cells.
DNA-PKcs are required to prevent endogenous DNA damage accumulation throughout the adult brain.
AIM2 (show AIM2 Proteins) reduced Akt (show AKT1 Proteins) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 Proteins) inhibitor reduced tumor load in Aim2 (show AIM2 Proteins)(-/-) mice
PRKDC proteins that mediate non-homologous end joining have been identified as TRIP13 (show TRIP13 Proteins) binding partners in head and neck cancer.
NR5A1 (show NR5A1 Proteins) prevents centriole splitting by inhibiting centrosomal DNA-PK activation and beta-catenin (show CTNNB1 Proteins) accumulation
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.
DNA-PK catalytic subunit
, DNA-dependent protein kinase catalytic subunit
, hyper-radiosensitivity of murine scid mutation, complementing 1
, protein kinase, DNA-activated, catalytic polypeptide
, protein kinase catalytic subunit (DNA-dependent protein kinase)
, DNA-activated protein kinase catalytic polypeptide
, DNA-dependent protein kinase catalytic subunit-like
, doxorubicin nephropathy
, severe combined immunodeficiency