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anti-Human XRCC3 Antibodies:
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Human Polyclonal XRCC3 Primary Antibody for IP, WB - ABIN151186
Yoshihara, Ishida, Kinomura, Katsura, Tsuruga, Tashiro, Asahara, Miyagawa: XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells. in The EMBO journal 2004
Show all 12 Pubmed References
Human Monoclonal XRCC3 Primary Antibody for ICC, IF - ABIN151307
Forget, Bennett, Knight: Xrcc3 is recruited to DNA double strand breaks early and independent of Rad51. in Journal of cellular biochemistry 2004
Show all 10 Pubmed References
Mouse (Murine) Polyclonal XRCC3 Primary Antibody for IHC, WB - ABIN3023006
Dong, Wang, Wang, Zhang, Zhu, Gao, Yang, Qin, Liang, Chen, Deng, Ning, Liang, Gao, Xu: A stress-induced cellular aging model with postnatal neural stem cells. in Cell death & disease 2014
XRCC3 gene SNPs could influence the tumour aggressiveness expressed by tumour grade in hepatocellular carcinoma.
XRCC3 deleterious variants were identified in breast and ovarian cancer cases.
DNA sequencing was performed for six single-nucleotide polymorphisms in the GSTP1 (show GSTP1 Antibodies), RAD51 (show RAD51 Antibodies), XRCC1 (show XRCC1 Antibodies) and XRCC3 genes in BC patients and the control group. Two variants in the 5'-UTR (show UTS2R Antibodies) of the XRCC3 and RAD51 (show RAD51 Antibodies) genes showed a significant association with susceptibility to breast cancer. Additionally, authors reported 2 mutations in intron 7 of the XRCC3 gene.
results indicate XRCC3 Thr241Met and TYMS (show TYMS Antibodies) 5'-UTR (show UTS2R Antibodies) VNTR polymorphisms are associated with time-to-metastasis, and may have potential biological roles in expediting the metastatic process
hypermethylation of homologous recombination DNA repair genes including RAD51B (show Rad51B Antibodies) and XRCC3 is associated with an inflamed phenotype in squamous cell cancers of the head and neck, lung and cervix.
Study suggested that RAD51 (show RAD51 Antibodies), XRCC1 (show XRCC1 Antibodies), and XRCC3 polymorphisms may be predictive factors for radiation-induced acute toxicity in rectal cancer patients treated with preoperative combined therapy.
XRCC1 Arg399Gln Gln/Gln genotype, Gln allele, and homozygote variants of XRCC3 Thr241Met polymorphism may be a risk factor for predisposition of Oral Squamous Cell Carcinoma in Turkish. In addition, XRCC3 Thr241Met genotype could be associated with tumor size and level of daily smoking.
The combined AA/AA (show TEAD1 Antibodies) genotype and GG/GA genotype frequencies for rs1799794 and rs709399 polymorphisms were significantly higher in thyroid cancer patients compared to control group when compared with combined AA/GG genotype as reference.
the association of six non-synonymous coding variants from XRCC1 (show XRCC1 Antibodies), XRCC3 and XPD (show ERCC2 Antibodies) genes with hepatocellular carcinoma risk, was assessed.
The analysis results showed that the following polymorphisms were correlated with susceptibility to lung cancer: rs4646903 in CYP1A1 (show CYP1A1 Antibodies) (P < 0.001), rs1048943 in CYP1A1 (show CYP1A1 Antibodies) (P < 0.001), rs1695 in GSTP1 (show GSTP1 Antibodies) (P < 0.05), rs13181 in ERCC2 (show ERCC2 Antibodies) (P < 0.001), and rs25487 in XRCC1 (show XRCC1 Antibodies) (P < 0.05); no such correlation existed in rs861539 in XRCC3 (P > 0.05).
the RAD51C-XRCC3-associated Holliday junction resolvase complex associates with crossovers and may play an essential role in the resolution of recombination intermediates prior to chromosome segregation
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
DNA repair protein XRCC3
, X-ray repair cross-complementing protein 3
, X-ray repair complementing defective repair in Chinese hamster cells 3
, DNA-repair protein XRCC3