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nuclear import of Nkx2-2 is mediated not only by the classical import pathway but also directly by imp (show IMPA1 Proteins) beta1 or imp 13 (show IPO13 Proteins)
NKX2-2 positivity was defined as moderate-to-strong nuclear immunoreactivity in at least 5% of cells
Our study suggests that CGT (show UGT8 Proteins) expression is controlled by balanced expression of the negative modulator OLIG2 (show OLIG2 Proteins) and positive regulator Nkx2.2, providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners.
lentiviral overexpression of transcription factors ASCL1 (show ASCL1 Proteins), SOX10 (show SOX10 Proteins), and NKX2.2 in NPCs was sufficient to induce Sox10 (show SOX10 Proteins) enhancer activity, OPC mRNA, and protein expression consistent with OPC fate
NKX2-2 and MNX1 (show MNX1 Proteins) are etiological genes for neonatal diabetes.
NKX2.2 is a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
The NKX2-2 can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching.
NKX2-1 (show NKX2-1 Proteins), NKX2-2, and MEF2C (show MEF2C Proteins) define oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL).
Functional analysis revealed that NKX2.2 is an EWS (show EWSR1 Proteins)/FLI (show FLII Proteins)-regulated gene that is necessary for oncogenic transformation in Ewing's sarcoma.
EWS (show EWSR1 Proteins)/FLI (show FLII Proteins) mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma
This suggests that Nkx2.2 is not only required in the early pancreatic progenitors, but has additional essential activities within the endocrine progenitor population.
Lmx1a (show LMX1A Proteins) is expressed in enterochromaffin cells and functions downstream of Nkx2.2.
nuclear import of Nkx2-2 is mediated not only by the classical import pathway but also directly by imp (show BRAP Proteins) beta1 or imp 13 (show IPO13 Proteins)
Demonstrate that a rare mature enteroendocrine cell subpopulation that is demarcated by Nkx2.2 expression display stem cell properties during normal intestinal epithelial homeostasis, but is not easily activated upon injury.
that Nkx2.2 and Nkx2.9 proteins play no role in the development of branchiovisceral motor neurons in hindbrain rostral to rhombomere 4.
These data identify Nkx2.2 as key regulator to determine neuronal subtypes in the p3 domain of the central nervous system.
The study demonstrates a previously unrecognized mechanism that controls insulin (show INS Proteins) expression through c-Abl (show ABL1 Proteins)-regulated NKx2.2 and GLUT2 (show SLC2A2 Proteins).
Our studies reveal that a subset of mouse perineurial cells are CNS-derived, express Nkx2.2, and are essential for motor nerve development.
Nato3 (show FERD3L Proteins) induces ectopic Foxa2 (show FOXA2 Proteins)-positive cells and indirectly downregulates Nkx2.2 expression.
Nkx2.2 promotes timely specification and differentiation of myelinating oligodendrocyte lineage cells from species representing different vertebrate taxa.
Nkx2.2 coordinately activates NeuroD1 with Ngn3 in the endocrine progenitor cell and plays a role in the maintenance of NeuroD1 expression to regulate beta cell function in the mature islet.
The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.
NK2 transcription factor related, locus 2
, homeobox protein XENK-2
, NK-2 homolog B
, NK2 transcription factor-like protein B
, homeobox protein NK-2 homolog B
, homeobox protein Nkx-2.2
, Drosophila NK2 transcription factor related, locus 2
, glycoprotein GP330, renal
, homeobox protein Nkx2-2
, homeobox protein NK-2 homolog B-A
, homeobox protein Nkx-2.2a