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anti-Human SOX2 Antibodies:
anti-Rat (Rattus) SOX2 Antibodies:
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Human Monoclonal SOX2 Primary Antibody for CyTOF, FACS - ABIN4899239
Günther, Schmidt, Phillips, Kemming, Kharbanda, Soriano, Modrusan, Meissner, Westphal, Lamszus: Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria. in Oncogene 2008
Show all 61 Pubmed References
Human Polyclonal SOX2 Primary Antibody for ICC, FACS - ABIN258037
Domyan, Ferretti, Throckmorton, Mishina, Nicolis, Sun: Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2. in Development (Cambridge, England) 2011
Show all 15 Pubmed References
Human Polyclonal SOX2 Primary Antibody for FACS, IF (cc) - ABIN669621
Liu, Li, Liu, Sui, Liu, Xiao, Zheng, Chen, Yao, Xing, Zhou, Li: A signature for induced pluripotent stem cell-associated genes in colorectal cancer. in Medical oncology (Northwood, London, England) 2013
Show all 7 Pubmed References
Human Monoclonal SOX2 Primary Antibody for FACS, IF - ABIN1882277
Biedler, Roffler-Tarlov, Schachner, Freedman: Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. in Cancer research 1978
Show all 7 Pubmed References
Mouse (Murine) Polyclonal SOX2 Primary Antibody for ICC, IF - ABIN2668593
Tompkins, Besnard, Lange, Wert, Keiser, Smith, Lang, Whitsett: Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells. in PLoS ONE 2009
Show all 6 Pubmed References
Human Monoclonal SOX2 Primary Antibody for ICC, IHC - ABIN969414
Dabdoub, Puligilla, Jones, Fritzsch, Cheah, Pevny, Kelley: Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 3 Pubmed References
Human Monoclonal SOX2 Primary Antibody for FACS - ABIN4895795
Kobold, Tams, Luetkens, Cao, Sezer, Bartels, Reinhard, Templin, Bartels, Hildebrandt, Lajmi, Marx, Haag, Bokemeyer, Kröger, Atanackovic: Patients with multiple myeloma develop SOX2-specific autoantibodies after allogeneic stem cell transplantation. in Clinical & developmental immunology 2011
Show all 3 Pubmed References
Fish Polyclonal SOX2 Primary Antibody for ICC, FACS - ABIN259586
Pfennig, Kurth, Meissner, Standke, Hoppe, Zieschang, Reitmayer, Göbel, Kretzschmar, Gutzeit: The social status of the male Nile tilapia (Oreochromis niloticus) influences testis structure and gene expression. in Reproduction (Cambridge, England) 2012
Show all 2 Pubmed References
Human Monoclonal SOX2 Primary Antibody for ELISA, WB - ABIN969413
Baer, Eriksson, Faull, Rees, Curtis: Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone. in Experimental neurology 2007
Show all 2 Pubmed References
Human Monoclonal SOX2 Primary Antibody for FACS - ABIN4895791
Huijbers, Bin Ali, Pritchard, Cozijnsen, Kwon, Proost, Song, de Vries, Badhai, Sutherland, Krimpenfort, Michalak, Jonkers, Berns: Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. in EMBO molecular medicine 2014
Show all 2 Pubmed References
Low SOX2 expression marks a distinct subset of adenoid cystic carcinoma of the head and neck and is associated with an advanced tumor stage
SOX2 overexpression in DPSCs promoted the regulation of odontoblast differentiation of DPSCs
SOX2 expression is dependent on contact with enhancers 700 kb downstream via CTCFdependent chromatin looping.
LncRNA SOX2-OT is a novel prognostic biomarker for osteosarcoma patients, it regulates osteosarcoma cells proliferation and motility through SOX2 modulation, and is correlated with patients' survival.
SOX2 overexpression is associated with cancer.
Histone acetyltransferase (show HAT Antibodies) EP300 (show EP300 Antibodies) is necessary for the transcription factor SOX2 activity in basal cells, including for induction of the squamous fate. EP300 (show EP300 Antibodies) copy number gains are common in squamous cell carcinoma SQCCs, including lung cancer SQCC cell lines.
NFATc2 (show NFAT1 Antibodies) enhances tumor-initiating phenotypes through the NFATc2 (show NFAT1 Antibodies)/SOX2/ ALDH1A1 (show ALDH1A1 Antibodies) axis in lung adenocarcinoma.
Block the activation of the VRK1 (show VRK1 Antibodies) promoter by Sox2.
Heterozygous loss-of-function mutations in SOX2 are the commonest cause of severe microphthalmia and anophthalmia.
This data demonstrated immunogenicity of SOX2, which is specifically overexpressed on pediatric glial tumor cells.
SOX2 localizes exclusively in the inner cell mass of bovine blastocysts, and its downregulation negatively impacts preimplantation development (show MTA2 Antibodies).
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Sox2 displayed relatively the same methylation levels between sperm and oocytes
SOX2 functions downstream of HH signaling to regulate lingual epithelium homeostasis.
SOX2 regulates proliferation through conserved mechanisms and target genes in both germ layers examined. Together, these findings demonstrate how SOX2 simultaneously regulates cell-type-specific, as well as core transcriptional programs in neural and endodermal stem cells.
Nup153 (show NUP153 Antibodies) and Sox2 bind and co-regulate hundreds of genes.
late neuronal development depends directly on Sox2 for differentiation and on the survival of hair cells, possibly derived from common neurosensory precursors.
These observations support a role for YY1 (show YY1 Antibodies) meditating and/or regulating the interaction of OCT4 (show POU5F1 Antibodies) and SOX2 at a posttranscriptional level.
The results revealed that the synthesized complex decoy can concomitantly target Sox2 and Oct4 (show POU5F1 Antibodies), which subsequently represses the stemness properties of mESCs compared to controls through decreasing cell viability, arresting cell cycle in G0 /G1 phases, inducing apoptosis, and modulating differentiation in mESCs despite the presence of 2i/LIF (show LIF Antibodies) in cell culture.
Sox2 activity is crucial for the induction of the neural progenitor gene Hes5 (show HES5 Antibodies) and for subsequent differentiation of the neuronal lineage.
Deletion of Sox2 specifically in Sox2(+) cells during incisor renewal revealed cellular plasticity that leads to the relatively rapid restoration of a Sox2-expressing cell population.
Tip110 deletion impaired embryonic and stem cell development involving downregulation of stem cell factors Nanog (show NANOG Antibodies), Oct4 (show POU5F1 Antibodies), and Sox2.
Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4 (show POU5F1 Antibodies), c-Myc (show MYC Antibodies), Sox2 and Klf4 (show KLF4 Antibodies).
these findings show that sox2 and sox3 (show SOX3 Antibodies) are together required for proper otic induction, but the level of expression must be tightly regulated to avoid suppression of differentiation and maintenance of pluripotency.
these data show that sox2 and sox3 (show SOX3 Antibodies) exhibit intrinsic differences in promoting sensory vs. neural competence, but at high levels these factors can mimic each other to enhance both states. Regional cofactors like pax2a and fgf8 (show FGF8 Antibodies) also modify sox2/3 functions.
Findings indicate a pivotal role for ZNF32 (show ZNF32 Antibodies) function in SOX2 expression and regeneration regulation.
Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration.
a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury
Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling.
significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos.
Knockdown of the four B1 sox (show PIPOX Antibodies) genes sox2/3/19a/19b resulted in severe developmental abnormalities.
sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration
shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs
Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.
Tail amputation results in a global increase of Sox2 levels and proliferation of Sox2-positive cells after spinal cord injury.
Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
Suggest that SOX2 directly upregulates FGF8 (show FGF8 Antibodies) gene expression in the early embryonic development of Xenopus.
Continuous expression of Sox1 (show SOX1 Antibodies) and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.
direct interaction and interdependence between the Otx2 (show OTX2 Antibodies) and Sox2 proteins coordinate Rax (show RAX Antibodies) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.
Sox3 functions as an activator to induce expression of the early neural genes, sox2 and geminin in the absence of protein synthesis and to indirectly inhibit the Bmp target Xvent2
A directional Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies)-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the retina.
Sox2 has a role in pluripotency in pig embryos
Overexpression of Sox2 or Oct4 (show POU5F1 Antibodies) in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (show FGF2 Antibodies) results in higher proliferation and differentiation compared to controls.
cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level
NANOG (show NANOG Antibodies) and SOX2 expression inversely correlated with the DNA methylation (show HELLS Antibodies) pattern in the promoter region
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
SRY-related HMG-box gene 2
, transcription factor SOX-2
, transcription factor SOX2
, SRY-box containing gene 2
, SRY-box 2
, SRY-related HMG-box 2
, sex determining region Y-box 2
, SRY (sex determining region Y)-box 2
, transcription factor Sox-2
, sex-determining region Y-box 2
, Sox2 transcription factor
, delta EF2a
, LOW QUALITY PROTEIN: transcription factor SOX-2