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SOX2 antibody (Middle Region)

SOX2 Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3044477
  • Target See all SOX2 Antibodies
    SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))
    Binding Specificity
    • 18
    • 16
    • 16
    • 16
    • 16
    • 15
    • 13
    • 12
    • 10
    • 10
    • 9
    • 8
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 171-183, Middle Region
    Reactivity
    • 203
    • 95
    • 68
    • 21
    • 13
    • 11
    • 11
    • 10
    • 8
    • 8
    • 7
    • 7
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 165
    • 42
    • 2
    Rabbit
    Clonality
    • 162
    • 47
    Polyclonal
    Conjugate
    • 103
    • 16
    • 15
    • 10
    • 10
    • 9
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SOX2 antibody is un-conjugated
    Application
    • 165
    • 109
    • 47
    • 46
    • 45
    • 40
    • 40
    • 28
    • 26
    • 25
    • 18
    • 15
    • 12
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purpose
    Rabbit IgG polyclonal antibody for Transcription factor SOX-2(SOX2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Sequence
    YSMMQDQLGY PQH
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Transcription factor SOX-2(SOX2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
    Gene Name: SRY(sex determining region Y)-box 2
    Protein Name: Transcription factor SOX-2
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence in the middle region of human SOX2(171-183aa YSMMQDQLGYPQH), different from the related mouse and rat sequence by one amino acid.
    Isotype
    IgG
    Top Product
    Discover our top product SOX2 Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • Yi, Xie, Liu, Wang, Xu, Liu, Li, Zhong, Peng: "Derivation and Identification of Motor Neurons from Human Urine-Derived Induced Pluripotent Stem Cells." in: Stem cells international, Vol. 2018, pp. 3628578, (2018) (PubMed).

    Cheng, Wang, Li, Wu, Han, Li, Chen, Xie, Huang, Du, Zhou: "MicroRNA-184 inhibits cell proliferation and invasion, and specifically targets TNFAIP2 in Glioma." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 27, (2015) (PubMed).

  • Target
    SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))
    Alternative Name
    SOX2 (SOX2 Products)
    Synonyms
    ANOP3 antibody, MCOPS3 antibody, RGD1565646 antibody, Sox-2 antibody, lcc antibody, ysb antibody, cb236 antibody, wu:fb83g04 antibody, wu:fc14d07 antibody, zgc:65860 antibody, zgc:77389 antibody, SRY-box2 antibody, Xsox-2 antibody, anop3 antibody, mcops3 antibody, sox-2 antibody, SRY-box 2 antibody, SRY box 2 antibody, SRY (sex determining region Y)-box 2 antibody, SRY-box 2 S homeolog antibody, SOX2 antibody, Sox2 antibody, sox2 antibody, sox2.S antibody
    Background
    SRY(sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency of undifferentiated embryonic stem cells. Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This gene is mapped to 3q26.33. It is found that SOX2 can regulate OCT3/4 expression and maintains ES pluripotency through upstream transcription factors. SOX2 is identified as a lineage-survival oncogene in lung and esophageal squamous cell carcinoma. In addition to those, SOX2 has a critical role in maintenance of embryonic and neural stem cells and holds great promise in research involving induced pluripotency, an emerging and very promising field of regenerative medicine.

    Synonyms: ANOP3 antibody|cb236 antibody|Delta EF2a antibody|lcc antibody|MCOPS3 antibody|MGC148683 antibody|MGC2413 antibody|RGD1565646 antibody|Sex determining region Y box 2 antibody|SOX 2 antibody|Sox2 antibody|SRY(sex determining region Y) box 2 antibody|SRY box containing gene 2 antibody|SRY related HMG box 2 antibody|SRY related HMG box gene 2 antibody|SRY-box 2 antibody|Transcription factor SOX 2 antibody|Transcription factor SOX-2 antibody|ysb antibody
    UniProt
    P48431
    Pathways
    Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis
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