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Alpaca (Vicugna pacos) Monoclonal TH Primary Antibody for IEM, ICC - ABIN617906
Lundius, Stroth, Vukojević, Terenius, Svenningsson: Functional GPR37 trafficking protects against toxicity induced by 6-OHDA, MPP+ or rotenone in a catecholaminergic cell line. in Journal of neurochemistry 2013
Show all 1427 Pubmed References
Fruit Fly (Drosophila melanogaster) Polyclonal TH Primary Antibody for ICC, IF - ABIN152458
Renfroe, Chronister, Haycock, Waymire: The localization of tyrosine hydroxylase-like immunoreactivity in the central nervous system: methodological considerations. in Brain research bulletin 1984
Show all 76 Pubmed References
Bird (Avian) Polyclonal TH Primary Antibody for ICC, IF - ABIN152459
Guo, Lai, Longhurst: Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat. in Brain research 2001
Show all 49 Pubmed References
Human Monoclonal TH Primary Antibody for IHC (fro), IHC (p) - ABIN3043094
Huang, Zhu, Zhang, Zhu, Liu, Zhu, Wang, Li, Yang, Dong, Liu, Chen, Zhang, Yang, Deng, Fan, Wang, Liu, Ma, Fu, Wu: S100+ cells: a new neuro-immune cross-talkers in lymph organs. in Scientific reports 2013
Show all 9 Pubmed References
Mammalian Polyclonal TH Primary Antibody for IHC (fro), IF - ABIN361503
Nakashima, Mori, Kaneko, Hayashi, Nagatsu, Ota: Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme. in Biochemical and biophysical research communications 2011
Show all 15 Pubmed References
Rat (Rattus) Polyclonal TH Primary Antibody for IHC (fro), IF - ABIN361502
Kish, Kalasinsky, Derkach, Schmunk, Guttman, Ang, Adams, Furukawa, Haycock: Striatal dopaminergic and serotonergic markers in human heroin users. in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001
Show all 12 Pubmed References
Mouse (Murine) Polyclonal TH Primary Antibody for ICC, IHC (fro) - ABIN152518
Lew, Garcia-Espana, Lee, Carr, Goldstein, Haycock, Meller: Increased site-specific phosphorylation of tyrosine hydroxylase accompanies stimulation of enzymatic activity induced by cessation of dopamine neuronal activity. in Molecular pharmacology 1999
Show all 5 Pubmed References
Mouse (Murine) Polyclonal TH Primary Antibody for IF, IHC - ABIN152552
Salvatore, Garcia-Espana, Goldstein, Deutch, Haycock: Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds. in Journal of neurochemistry 2000
Show all 4 Pubmed References
Human Monoclonal TH Primary Antibody for ICC, IF - ABIN151520
Zhang, Ng, Li, He, Anderson, Sun, Zhou: Prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis. in The Journal of biological chemistry 2007
Show all 3 Pubmed References
Rat (Rattus) Polyclonal TH Primary Antibody for ICC, IHC (fro) - ABIN152553
Andres-Mateos, Perier, Zhang, Blanchard-Fillion, Greco, Thomas, Ko, Sasaki, Ischiropoulos, Przedborski, Dawson, Dawson: DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 3 Pubmed References
TH is a robust interaction partner of different 14-3-3 (show YWHAQ Antibodies) dimer types with moderate variability between the 14-3-3 (show YWHAQ Antibodies) dimers on their regulation of TH.
Retinol activates tyrosine hydroxylase via two sequential non-genomic mechanisms, which have not previously been characterized. These mechanisms are likely to operate in vivo to facilitate the stress response.
IFN-alpha (show IFNA Antibodies) mediated activation of ERK1/2 appeared to be responsible for the increased phosphorylation of tyrosine hydroxylase.
This study demonstrated that the expression patterns of the calcitonin-related polypeptide alpha (show CALCA Antibodies) and tyrosine hydroxylase formed opposing gradients, with tyrosine hydroxylase being preferentially expressed in apical and calcitonin-related polypeptide alpha (show CALCA Antibodies) in basal type II afferent neurons, indicating heterogeneity among type II afferent neurons.
Study used Cre-lox (show LOX Antibodies) technology to selectively ablate tyrosine hydroxylase (TH) from Kiss1 (show KISS1 Antibodies) cells. Surprisingly, despite a practically complete knock-out of TH from Kiss1 (show KISS1 Antibodies) cells, study found that all aspects of puberty, reproductive hormone secretion, and fertility were normal in Kiss THKOs. This suggests that dopamine synthesized in Kiss1 (show KISS1 Antibodies) cells is not required for normal puberty and reproduction.
These findings reveal that Th and Gad1 (show GAD1 Antibodies) share a transcription regulatory mechanism that facilitates odorant-dependent regulation of dopamine and GABA expression levels.
deletion of Th in hematopoietic cells of adult mice neither alters energy expenditure upon cold exposure nor reduces browning in inguinal adipose tissue. Bone marrow-derived macrophages did not release NE in response to stimulation with IL-4 (show IL4 Antibodies), and conditioned media from IL-4 (show IL4 Antibodies)-stimulated macrophages failed to induce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1 (show UCP1 Antibodies)), in adipocytes.
The neurogenic contractions were higher in the sickle cell disease, in association with elevated tyrosine hydroxylase phosphorylated at Ser (show SIGLEC1 Antibodies)-31 and total tyrosine hydroxylase protein expression, as well as increased tyrosine hydroxylase mRNA expression.
these data demonstrate a novel interaction between Hsc70 (show HSPA8 Antibodies) and TH that regulates the activity and localization of the enzyme to synaptic vesicles, suggesting an important role for Hsc70 (show HSPA8 Antibodies) in dopamine homeostasis.
TH gene overexpression promotes the polarization and differentiation of CD4 (show CD4 Antibodies)+ cells towards Th2 cells.
The TH-immunopositive fibres detected in the orbitofrontal cortices of the DISC1 (show DISC1 Antibodies) KO mice were significantly shorter than those seen in the wild-type mice.
Real-time PCR analyses revealed that social defeat significantly increased tyrosine hydroxylase in the ventral tegmental area.
These results revealed a new role of the canonical Lrp5 (show LRP5 Antibodies)/6-beta-catenin (show CTNNB1 Antibodies) pathway in regulating the morphogenesis of the cerebellum during postnatal development.
Achilles tendon tenocytes produce tyrosine hydroxylase.
A novel heterozygous variant in tyrosine hydroxylase was identified in Chinese patients with dopa-responsive dystonia.
The purpose of this study is to investigate the clinical significance of tyrosine hydroxylase (TH) expression in peripheral blood (PB) at diagnosis in patients with neuroblastoma (show ARHGEF16 Antibodies).. The treatment intensity should be tailored according to TH expression in PB at diagnosis.
Results show that the positive rates and expression levels of nestin (show NES Antibodies), tyrosine hydroxylase (TH), GFAP (show GFAP Antibodies) and IL-17 (show IL17A Antibodies) were significantly decreased while Foxp3 (show FOXP3 Antibodies) and the ratio of Foxp3 (show FOXP3 Antibodies)/IL-17 (show IL17A Antibodies) were statistically elevated in BM of AML (show RUNX1 Antibodies) patients.
Data suggest that TH phosphorylated at Ser (show SIGLEC1 Antibodies)-31 co-distributes with Golgi complexes and synaptic-like vesicles in rat and human dopaminergic neurons/cell lines; Ser (show SIGLEC1 Antibodies)-31 phosphorylation may regulate TH subcellular localization by enabling its transport along microtubules, notably toward the projection terminals.
No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2, DRD1 (show DRD1 Antibodies), DRD3 (show DRD3 Antibodies) and COMT (show COMT Antibodies). Conversely, some alleles of the 12 sNPs from the DRD2 (show DRD2 Antibodies) locus and the 5 from the MAOA (show MAOA Antibodies) locus showed significant associations with excessive alcohol consumption.
Results show that metastasis-associated protein 1 (MTA1 (show MTA1 Antibodies)) and tyrosine hydroxylase (TH) levels were significantly down-regulated in Parkinson disease (PD) samples as compared with normal brain tissue
the reduction of tyrosine hydroxylase-immunoreactive neurons occurring in the locus coeruleus after perinatal hypoxic insults persists into adulthood
In high-risk metastatic Neuroblastoma (show ARHGEF16 Antibodies), TH and DCX (show DCX Antibodies) mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses.
the allelic frequency of the TH01 marker in 171 Swiss sudden infant death syndrome (SIDS (show IDS Antibodies)) infants and 500 healthy and gender-matched Caucasian adults showed that the 9.3 allele is similarly distributed in SIDS (show IDS Antibodies) cases and controls (27.2% vs. 25.6%; p-value = 0.562).
The biochemically conserved regulatory mechanisms of recombinant DTH parallel those from mammals.
maternal as well as embryonic effects on the secretion and/or functionality of Tyrosine hydroxylase (pale) may play roles in the early developmental program of the organism.
activity of tyrosine hydroxylase is also increased by this interaction, in excess (show RCC1 Antibodies) of the stimulation resulting from phosphorylation alone
Tyrosine hydroxylase is co-localized with egr1 (show EGR1 Antibodies) in olfactory bulb throughout brain development.
Transiently knocked down tyrosine hydroxylase (TH, the rate limiting enzyme in DA synthesis) gene expression in the early stages of brain development was studied in zebrafish.
Overall, TH1 (show TH1L Antibodies)+ and serotonergic system innervation is massively altered in the successfully regenerated spinal cord of adult zebrafish.
The tyrosine hydroxylase-immunoreactive cells in zebrafish are limited to very specific subpopulations of the amacrine cells.
mRNA expression of TH1 (show TH1L Antibodies) and TH2 is differentially affected by hypoxia exposure in larvae and adults. TH1 (show TH1L Antibodies) mRNA levels are much higher in eye and brain
th1 (show TH1L Antibodies) is predominant in the brain of zebrafish and th2 in the periphery.
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
, tyrosine 3-monooxygenase
, tyrosine hydroxylase
, dystonia 14
, XBB70 group VII
, drosophila tyrosine hydroxylase
, tyrosine hydrodroxylase
, tyrosine hydroxylase S homeolog