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Alpaca (Vicugna pacos) Monoclonal TH Primary Antibody for IEM, ICC - ABIN617906
Lundius, Stroth, Vukojević, Terenius, Svenningsson: Functional GPR37 trafficking protects against toxicity induced by 6-OHDA, MPP+ or rotenone in a catecholaminergic cell line. in Journal of neurochemistry 2013
Show all 1421 Pubmed References
Bird (Avian) Polyclonal TH Primary Antibody for ICC, IF - ABIN152459
Guo, Lai, Longhurst: Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat. in Brain research 2001
Show all 47 Pubmed References
Fruit Fly (Drosophila melanogaster) Polyclonal TH Primary Antibody for ICC, IF - ABIN152458
Renfroe, Chronister, Haycock, Waymire: The localization of tyrosine hydroxylase-like immunoreactivity in the central nervous system: methodological considerations. in Brain research bulletin 1984
Show all 68 Pubmed References
Human Monoclonal TH Primary Antibody for IHC (fro), IHC (p) - ABIN3043094
Huang, Zhu, Zhang, Zhu, Liu, Zhu, Wang, Li, Yang, Dong, Liu, Chen, Zhang, Yang, Deng, Fan, Wang, Liu, Ma, Fu, Wu: S100+ cells: a new neuro-immune cross-talkers in lymph organs. in Scientific reports 2013
Show all 9 Pubmed References
Mammalian Polyclonal TH Primary Antibody for IHC (fro), IF - ABIN361503
Nakashima, Mori, Kaneko, Hayashi, Nagatsu, Ota: Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme. in Biochemical and biophysical research communications 2011
Show all 15 Pubmed References
Mouse (Murine) Polyclonal TH Primary Antibody for ICC, IHC (fro) - ABIN152518
Lew, Garcia-Espana, Lee, Carr, Goldstein, Haycock, Meller: Increased site-specific phosphorylation of tyrosine hydroxylase accompanies stimulation of enzymatic activity induced by cessation of dopamine neuronal activity. in Molecular pharmacology 1999
Show all 5 Pubmed References
Rat (Rattus) Polyclonal TH Primary Antibody for IHC (fro), IF - ABIN361502
Kish, Kalasinsky, Derkach, Schmunk, Guttman, Ang, Adams, Furukawa, Haycock: Striatal dopaminergic and serotonergic markers in human heroin users. in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001
Show all 12 Pubmed References
Mouse (Murine) Polyclonal TH Primary Antibody for IF, IHC - ABIN152552
Salvatore, Garcia-Espana, Goldstein, Deutch, Haycock: Stoichiometry of tyrosine hydroxylase phosphorylation in the nigrostriatal and mesolimbic systems in vivo: effects of acute haloperidol and related compounds. in Journal of neurochemistry 2000
Show all 4 Pubmed References
Human Polyclonal TH Primary Antibody for FACS, IF (p) - ABIN723635
Yu, Liao, Liu, Chen, Feng, Fu: Overexpression of lactate dehydrogenase-A in human intrahepatic cholangiocarcinoma: its implication for treatment. in World journal of surgical oncology 2014
Show all 3 Pubmed References
Human Monoclonal TH Primary Antibody for ICC, IF - ABIN151520
Zhang, Ng, Li, He, Anderson, Sun, Zhou: Prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis. in The Journal of biological chemistry 2007
Show all 3 Pubmed References
The Khc73 stalk/14-3-3 (show YWHAZ Antibodies)/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
role of 14-3-3epsilon in germ cell migration
14-3-3epsilon acts as a biochemical control point for axon guidance in Drosophila, silencing Plexin A repulsive axon guidance and regulating a semaphorin repulsion/integrin adhesion switch.
We conclude that 14-3-3epsilon is required for Rab11 (show RAB11A Antibodies)-positive vesicle function, which in turn enables antimicrobial peptide (show cAMP Antibodies) secretion during an innate immune response.
Hpo (show GFER Antibodies) signaling inhibited Yki (show YAP1 Antibodies) nuclear localization and activity by phosphorylating Yki (show YAP1 Antibodies) and both isoforms of 14-3-3 (show YWHAZ Antibodies), 14-3-3varepsilon and 14-3-3zeta (show YWHAZ Antibodies), regulate Yki (show YAP1 Antibodies) activity through modulating its subcellular localization.
The biochemically conserved regulatory mechanisms of recombinant DTH parallel those from mammals.
maternal as well as embryonic effects on the secretion and/or functionality of Tyrosine hydroxylase (pale) may play roles in the early developmental program of the organism.
activity of tyrosine hydroxylase is also increased by this interaction, in excess (show RCC1 Antibodies) of the stimulation resulting from phosphorylation alone
Drosophila 14-3-3/PAR-5 (show YWHAZ Antibodies) is an essential mediator of PAR-1 (show F2R Antibodies) function in axis formation.
PAR-1 (show F2R Antibodies) phosphorylates Bazooka/PAR-3 (show PARD3 Antibodies) on two conserved serines to generate 14-3-3 (show YWHAZ Antibodies) binding sites. This inhibits formation of the Bazooka (show PARD3 Antibodies)/PAR-6 (show PARD6A Antibodies)/aPKC complex by blocking Bazooka (show PARD3 Antibodies) oligomerization and binding to aPKC.
Data suggest that TH phosphorylated at Ser (show SIGLEC1 Antibodies)-31 co-distributes with Golgi complexes and synaptic-like vesicles in rat and human dopaminergic neurons/cell lines; Ser (show SIGLEC1 Antibodies)-31 phosphorylation may regulate TH subcellular localization by enabling its transport along microtubules, notably toward the projection terminals.
TH is a robust interaction partner of different 14-3-3 (show YWHAQ Antibodies) dimer types with moderate variability between the 14-3-3 (show YWHAQ Antibodies) dimers on their regulation of TH.
No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2, DRD1 (show DRD1 Antibodies), DRD3 (show DRD3 Antibodies) and COMT (show COMT Antibodies). Conversely, some alleles of the 12 sNPs from the DRD2 (show DRD2 Antibodies) locus and the 5 from the MAOA (show MAOA Antibodies) locus showed significant associations with excessive alcohol consumption.
Results show that metastasis-associated protein 1 (MTA1 (show MTA1 Antibodies)) and tyrosine hydroxylase (TH) levels were significantly down-regulated in Parkinson disease (PD) samples as compared with normal brain tissue
the reduction of tyrosine hydroxylase-immunoreactive neurons occurring in the locus coeruleus after perinatal hypoxic insults persists into adulthood
In high-risk metastatic Neuroblastoma (show ARHGEF16 Antibodies), TH and DCX (show DCX Antibodies) mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses.
the allelic frequency of the TH01 marker in 171 Swiss sudden infant death syndrome (SIDS (show IDS Antibodies)) infants and 500 healthy and gender-matched Caucasian adults showed that the 9.3 allele is similarly distributed in SIDS (show IDS Antibodies) cases and controls (27.2% vs. 25.6%; p-value = 0.562).
This study showed that a new tyrosine hydroxylase knock-in mouse model of l-DOPA-responsive dystonia.
The mutant tyrosine hydroxylase enzyme was unstable and exhibited deficient stabilization by catecholamines, leading to decline of brain tyrosine hydroxylase-immunoreactivity in the Th knock-in mice.
Thus, the hTH-GFP reporter rat should be a valuable tool for Parkinson's disease research.
These findings reveal that Th and Gad1 share a transcription regulatory mechanism that facilitates odorant-dependent regulation of dopamine and GABA expression levels.
deletion of Th in hematopoietic cells of adult mice neither alters energy expenditure upon cold exposure nor reduces browning in inguinal adipose tissue. Bone marrow-derived macrophages did not release NE in response to stimulation with IL-4 (show IL4 Antibodies), and conditioned media from IL-4 (show IL4 Antibodies)-stimulated macrophages failed to induce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1 (show UCP1 Antibodies)), in adipocytes.
The neurogenic contractions were higher in the sickle cell disease, in association with elevated tyrosine hydroxylase phosphorylated at Ser (show SIGLEC1 Antibodies)-31 and total tyrosine hydroxylase protein expression, as well as increased tyrosine hydroxylase mRNA expression.
these data demonstrate a novel interaction between Hsc70 (show HSPA8 Antibodies) and TH that regulates the activity and localization of the enzyme to synaptic vesicles, suggesting an important role for Hsc70 (show HSPA8 Antibodies) in dopamine homeostasis.
TH gene overexpression promotes the polarization and differentiation of CD4 (show CD4 Antibodies)+ cells towards Th2 cells.
The TH-immunopositive fibres detected in the orbitofrontal cortices of the DISC1 (show DISC1 Antibodies) KO mice were significantly shorter than those seen in the wild-type mice.
Real-time PCR analyses revealed that social defeat significantly increased tyrosine hydroxylase in the ventral tegmental area.
These results revealed a new role of the canonical Lrp5 (show LRP5 Antibodies)/6-beta-catenin (show CTNNB1 Antibodies) pathway in regulating the morphogenesis of the cerebellum during postnatal development.
psychostimulants induce downregulation of DRD1a (show DRD1 Antibodies) and DRD2 (show DRD2 Antibodies) mRNA expression and upregulation of tyrosine hydroxylase protein expression in the testis
Deletion of the CB2 r (show CNR2 Antibodies) gene increased preference for and vulnerability to ethanol consumption, at least in part, by increased ethanol-induced sensitivity of the TH and mu-opioid receptor (show OPRM1 Antibodies) gene expressions in mesolimbic neurons.
Achilles tendon tenocytes produce tyrosine hydroxylase.
Retinol activates tyrosine hydroxylase via two sequential non-genomic mechanisms, which have not previously been characterized. These mechanisms are likely to operate in vivo to facilitate the stress response.
IFN-alpha (show IFNA Antibodies) mediated activation of ERK1/2 (show MAPK1/3 Antibodies) appeared to be responsible for the increased phosphorylation of tyrosine hydroxylase.
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
, XBB70 group VII
, drosophila tyrosine hydroxylase
, tyrosine hydrodroxylase
, tyrosine hydroxylase
, tyrosine 3-monooxygenase
, suppressor of Ras85D 3-9
, dystonia 14
, tyrosine 3-hydroxylase