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TH is a robust interaction partner of different 14-3-3 (show YWHAQ Proteins) dimer types with moderate variability between the 14-3-3 (show YWHAQ Proteins) dimers on their regulation of TH.
Retinol activates tyrosine hydroxylase via two sequential non-genomic mechanisms, which have not previously been characterized. These mechanisms are likely to operate in vivo to facilitate the stress response.
IFN-alpha (show IFNA Proteins) mediated activation of ERK1/2 appeared to be responsible for the increased phosphorylation of tyrosine hydroxylase.
Study used Cre-lox (show LOX Proteins) technology to selectively ablate tyrosine hydroxylase (TH) from Kiss1 (show KISS1 Proteins) cells. Surprisingly, despite a practically complete knock-out of TH from Kiss1 (show KISS1 Proteins) cells, study found that all aspects of puberty, reproductive hormone secretion, and fertility were normal in Kiss THKOs. This suggests that dopamine synthesized in Kiss1 (show KISS1 Proteins) cells is not required for normal puberty and reproduction.
These findings reveal that Th and Gad1 share a transcription regulatory mechanism that facilitates odorant-dependent regulation of dopamine and GABA expression levels.
deletion of Th in hematopoietic cells of adult mice neither alters energy expenditure upon cold exposure nor reduces browning in inguinal adipose tissue. Bone marrow-derived macrophages did not release NE in response to stimulation with IL-4 (show IL4 Proteins), and conditioned media from IL-4 (show IL4 Proteins)-stimulated macrophages failed to induce expression of thermogenic genes, such as uncoupling protein 1 (Ucp1 (show UCP1 Proteins)), in adipocytes.
The neurogenic contractions were higher in the sickle cell disease, in association with elevated tyrosine hydroxylase phosphorylated at Ser (show SIGLEC1 Proteins)-31 and total tyrosine hydroxylase protein expression, as well as increased tyrosine hydroxylase mRNA expression.
these data demonstrate a novel interaction between Hsc70 (show HSPA8 Proteins) and TH that regulates the activity and localization of the enzyme to synaptic vesicles, suggesting an important role for Hsc70 (show HSPA8 Proteins) in dopamine homeostasis.
TH gene overexpression promotes the polarization and differentiation of CD4 (show CD4 Proteins)+ cells towards Th2 cells.
The TH-immunopositive fibres detected in the orbitofrontal cortices of the DISC1 (show DISC1 Proteins) KO mice were significantly shorter than those seen in the wild-type mice.
Real-time PCR analyses revealed that social defeat significantly increased tyrosine hydroxylase in the ventral tegmental area.
These results revealed a new role of the canonical Lrp5 (show LRP5 Proteins)/6-beta-catenin (show CTNNB1 Proteins) pathway in regulating the morphogenesis of the cerebellum during postnatal development.
psychostimulants induce downregulation of DRD1a (show DRD1 Proteins) and DRD2 (show DRD2 Proteins) mRNA expression and upregulation of tyrosine hydroxylase protein expression in the testis
Achilles tendon tenocytes produce tyrosine hydroxylase.
A novel heterozygous variant in tyrosine hydroxylase was identified in Chinese patients with dopa-responsive dystonia.
The purpose of this study is to investigate the clinical significance of tyrosine hydroxylase (TH) expression in peripheral blood (PB) at diagnosis in patients with neuroblastoma (show ARHGEF16 Proteins).. The treatment intensity should be tailored according to TH expression in PB at diagnosis.
Results show that the positive rates and expression levels of nestin (show NES Proteins), tyrosine hydroxylase (TH), GFAP (show GFAP Proteins) and IL-17 (show IL17A Proteins) were significantly decreased while Foxp3 (show FOXP3 Proteins) and the ratio of Foxp3 (show FOXP3 Proteins)/IL-17 (show IL17A Proteins) were statistically elevated in BM of AML (show RUNX1 Proteins) patients.
Data suggest that TH phosphorylated at Ser (show SIGLEC1 Proteins)-31 co-distributes with Golgi complexes and synaptic-like vesicles in rat and human dopaminergic neurons/cell lines; Ser (show SIGLEC1 Proteins)-31 phosphorylation may regulate TH subcellular localization by enabling its transport along microtubules, notably toward the projection terminals.
No statistically significant differences were found between cases and controls for the allele frequencies in five genes: TH, SLC18A2, DRD1 (show DRD1 Proteins), DRD3 (show DRD3 Proteins) and COMT (show COMT Proteins). Conversely, some alleles of the 12 sNPs from the DRD2 (show DRD2 Proteins) locus and the 5 from the MAOA (show MAOA Proteins) locus showed significant associations with excessive alcohol consumption.
Results show that metastasis-associated protein 1 (MTA1 (show MTA1 Proteins)) and tyrosine hydroxylase (TH) levels were significantly down-regulated in Parkinson disease (PD) samples as compared with normal brain tissue
the reduction of tyrosine hydroxylase-immunoreactive neurons occurring in the locus coeruleus after perinatal hypoxic insults persists into adulthood
In high-risk metastatic Neuroblastoma (show ARHGEF16 Proteins), TH and DCX (show DCX Proteins) mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses.
the allelic frequency of the TH01 marker in 171 Swiss sudden infant death syndrome (SIDS (show IDS Proteins)) infants and 500 healthy and gender-matched Caucasian adults showed that the 9.3 allele is similarly distributed in SIDS (show IDS Proteins) cases and controls (27.2% vs. 25.6%; p-value = 0.562).
The biochemically conserved regulatory mechanisms of recombinant DTH parallel those from mammals.
maternal as well as embryonic effects on the secretion and/or functionality of Tyrosine hydroxylase (pale) may play roles in the early developmental program of the organism.
activity of tyrosine hydroxylase is also increased by this interaction, in excess (show RCC1 Proteins) of the stimulation resulting from phosphorylation alone
Tyrosine hydroxylase is co-localized with egr1 (show EGR1 Proteins) in olfactory bulb throughout brain development.
Transiently knocked down tyrosine hydroxylase (TH, the rate limiting enzyme in DA synthesis) gene expression in the early stages of brain development was studied in zebrafish.
Overall, TH1 (show TH1L Proteins)+ and serotonergic system innervation is massively altered in the successfully regenerated spinal cord of adult zebrafish.
The tyrosine hydroxylase-immunoreactive cells in zebrafish are limited to very specific subpopulations of the amacrine cells.
mRNA expression of TH1 (show TH1L Proteins) and TH2 is differentially affected by hypoxia exposure in larvae and adults. TH1 (show TH1L Proteins) mRNA levels are much higher in eye and brain
th1 (show TH1L Proteins) is predominant in the brain of zebrafish and th2 in the periphery.
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
, tyrosine 3-monooxygenase
, tyrosine hydroxylase
, dystonia 14
, XBB70 group VII
, drosophila tyrosine hydroxylase
, tyrosine hydrodroxylase
, tyrosine hydroxylase S homeolog