Browse our ADRA2A Proteins (ADRA2A)

Mouse (Murine) Adrenergic, alpha-2A-, Receptor (ADRA2A) interaction partners

1. Study showed that alpha2A adrenergic receptors are highly expressed in the cell bodies and axons of mesoprefrontal dopaminergic neurons provides a morphological basis to the vast functional evidence that somatodendritic and nerve-terminal alpha2A adrenergic receptors control dopaminergic activity and dopamine release in the prefrontal cortex.

2. Results suggested that nicotine produces anxiogenic-like behaviors which may be mediated through a basolateral amygdala alpha2-adrenoceptor mechanism

3. The current study demonstrated that a physiological concentration of adrenaline attenuates insulin release via coupling of alpha2A-adrenoceptor to cAMP/TRPM2 signaling.

4. Results suggest that slow ventral root potential suppression by dexmedetomidine and xylazine is mainly mediated by alpha2A-AR.

5. The study suggests that a2-adrenoreceptors/catecholamine play pivotal role in psychological stress-induced colitis.

6. This study showed that reduced expression of the alpha2A-adrenoceptor (Adra2a) which modulate antidepressant action in hippocampus.

7. Fzd5 and Trvp6 are expressed in the epithelial layer of the prospective pyroric and glandular stomach, respectively and Adra2a is expressed in the mesenchymal region of the stomach primordium at the beginning of morphogenesis.

8. The sympathetic hyperactivity present in alpha2A/alpha2C-ARKO mice alters vascular reactivity only in certain types of arteries

9. Data indicate that activation of alpha(2A) adrenergic receptor (alpha(2A)AR) signaling disrupts transgenic amyloid precursor protein (APP) interaction with sorting-related receptor with A repeat (SorLA) in cells and brain.

10. local modulation of alpha-adrenergic reeptor in the ventrolateral preoptic nucleus destabilizes, but does not fully antagonize, the anesthetic state, thus priming the brain for anesthetic emergence.

11. alpha2A/alpha2C-adrenoceptor deletion accelerates cutaneous wound healing in mice

12. Our findings indicate that IC noradrenergic neurotransmission acting through activation of both alpha1- and alpha2-adrenoceptors has a facilitatory influence on pressor response to acute restraint stress.

13. Thus, our study reveals distinct actions of PBN afferents within the BNST and suggests that alpha(2A)-AR agonists may filter excitatory transmission in the BNST by inhibiting a component of the PBN input while enhancing the actions of other inputs.

14. The time course of Adra2a- and dopamine D2R-mediated transmission reflects underlying differences in the extent of spillover and pooling of inhibitory postsynaptic potentials (IPSPs).

15. Activation of alpha2A-AR and muscarinic M3 receptors affects the initial [Ca(2+)] response to increase of glucose from 3 to 20mM in BETA-cells.

16. Canonical betaAR-mediated signaling coupled to PKA activation results in phosphorylation of spinophilin, disrupting its interaction with alpha2AARs and accelerating alpha2AAR endocytic responses.

17. Aadrenergic alpha2A receptors are involved in the antinociceptive effect produced by exercise in rats and mice.

18. conformational change of alpha(2A)AR by voltage is independent from receptor-G protein docking and regulates receptor signaling, including beta-arrestin binding, activation of G proteins, and G protein-activated inwardly rectifying K(+) currents

19. adra2 receptor stimulation significantly modifies migration of cortical interneurons.

Human Adrenergic, alpha-2A-, Receptor (ADRA2A) interaction partners

1. Rs1800544 polymorphism is associated with bone turnover markers level in Chinese elderly individuals with osteoporotic fractures, indicating the involvement of genetic variation of a2A-AR gene in bone metabolism.

2. ADRA2A genetic variation contributes independently to the risk of GDM in Caucasian women.

3. Results describe association of ADRA2A rs553668 with type 2 diabetes in a Mexican population.

4. Significant group*genotype interactions were found for 3 ADRA2A variants revealing steeper delay discounting (DD) in cocaine users (but not controls) carrying the G-allele of rs1800544, the T-allele of rs521674 and the C-allele of rs602618. High ADRA2A mRNA expression levels were significantly associated with a reduced tendency to choose smaller more immediate rewards in cocaine users.

5. The summary of this study, none of the examined variants reached the threshold for statistical significance after correction for multiple testing. The SNP rs1800544 in ADRA2A, revealed nominally significant association, but the direction of effect was the opposite to that reported in previous studies conducted in children and adolescents.

6. The results of this study suggested that ADRA2A rs3750625 contributes to poststress musculoskeletal pain severity by modulating miR-34a regulation

7. This study reveled that ADA2A are up regulate in peripheral blood mononuclear cells in patient with multiple sclerosis.

8. Results show that ADRA2A genetic variants are associated with blood glucose and stress-induced hyperglycemia after acute myocardial infarction in Caucasians.

9. These findings suggest that Gi1 interacts only with active GPCRs and that the well known high speed of GPCR signal transduction does not require preassembly between G proteins and GPCRs.

10. ADRA2A Germline Gene Polymorphism is Associated to the Severity, but not to the Risk, of Breast Cancer.

11. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2

12. The ADRA2A C-1291G and COMT Val158Met genotypes and sex interact in predicting detection and perception of emotional valence in facial expressions

13. ADRA2a is associated with heart rate recovery after exercise.

14. Study is in line with previous reports of an association between ADRA2A gene variants and general reaction time variability during response selection tasks

15. Genetic association of ADRA2A single nucleotide polymorphism with metabolic syndrome and high level insulin among the Tatars

16. The rs10885122G>T polymorphism of the ADRA2A gene was not associated with type 2 diabetes mellitus in Euro-Brazilians, and carriers of the T allele had lower body weight in the presence of type 2 diabetes mellitus.

17. Common polymorphisms in the ADRA2A gene are not associated with orthostatic hypotension risk in Chinese.

18. The alpha2a AR expression in breast cancer was associated with Her-2 status (P = 0.048) and a marginal significance was observed between alpha2a AR expression and estrogen receptor (P = 0.061).

19. Study found evidence that DNA variation in the ADRA2A gene may be causally related to ADHD-like behaviors, in part through its influence on intra-individual variability

20. The accuracy of prediction for breast cancer relapse based solely on the expression of ADRA2A gene is high.

Pig (Porcine) Adrenergic, alpha-2A-, Receptor (ADRA2A) interaction partners

1. islets express mRNA transcripts for sulfonylurea receptor 1 (Sur1), inward rectifying potassium channel (Kir6.2, associated with Sur1), glucagon-like peptide 1 receptor (GLP1R), and adrenergic receptor alpha 2A (ADRalpha2A)

Rabbit Adrenergic, alpha-2A-, Receptor (ADRA2A) interaction partners

1. Proliferation of Achilles tenocytes in overuse tendinosis is induced by ADRA2A stimulation and inhibited by an ADRA2A blocker.