Browse our anti-Amyloid beta (A4) Precursor-Like Protein 2 (APLP2) Antibodies

Full name:: anti-Amyloid beta (A4) Precursor-Like Protein 2 Antibodies (APLP2)

On www.antibodies-online.com are 109 Amyloid beta (A4) Precursor-Like Protein 2 (APLP2) Antibodies from 21 different suppliers available. Additionally we are shipping Amyloid beta (A4) Precursor-Like Protein 2 Proteins (11) and Amyloid beta (A4) Precursor-Like Protein 2 Kits (9) and many more products for this protein. A total of 136 Amyloid beta (A4) Precursor-Like Protein 2 products are currently listed.

Synonyms:: AI790698, APLP-2, APLP2, aplp2 A, aplp2 B, Apph, APPL2, CDEBP, MGC86389, si:dkey-11k4.3, WALPLP2

list all antibodies	Gene Name	GeneID	UniProt
	APLP2	334	Q06481
	APLP2	11804	Q06335
	APLP2	64312
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Top referenced anti-Amyloid beta (A4) Precursor-Like Protein 2 Antibodies

Human Polyclonal APLP2 Primary Antibody for ICC, IF - ABIN4281104 : Jackson, Du, Janesko-Feldman, Vagni, Dezfulian, Poloyac, Jackson, Clark, Kochanek: The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015 (PubMed)
Human Polyclonal APLP2 Primary Antibody for WB - ABIN513407 : Jelic, Hagman, Yamamoto, Teranishi, Nishimura, Winblad, Pavlov: Abnormal platelet amyloid-? protein precursor (A?PP) metabolism in Alzheimer's disease: identification and characterization of a new A?PP isoform as potential biomarker. in Journal of Alzheimer's disease : JAD 2013 (PubMed)
Human Polyclonal APLP2 Primary Antibody for EIA, WB - ABIN950473 : Tuli, Sharma, Capek, Naslavsky, Caplan, Solheim: Mechanism for amyloid precursor-like protein 2 enhancement of major histocompatibility complex class I molecule degradation. in The Journal of biological chemistry 2009 (PubMed)
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More Antibodies against Amyloid beta (A4) Precursor-Like Protein 2 Interaction Partners

Human Amyloid beta (A4) Precursor-Like Protein 2 (APLP2) interaction partners

These findings suggest that the identified APLP2, RRM2 (show RRM2 Antibodies), and PRC1 (show PRC1 Antibodies) signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium.
This paper demonstrates an important role for APLP2 in refractive development in mice and humans, suggesting a high level of evolutionary conservation of the signaling pathways underlying refractive eye development.
Data show that amyloid precursor-like protein 2 (APLP2) expression is elevated in pancreatic cancer metastases.
We conclude that PCSK9 (show PCSK9 Antibodies) enhances the degradation of the LDLR (show LDLR Antibodies) independently of either APLP2 or sortilin (show SORT1 Antibodies) both ex vivo and in mice.
APLP1 (show APLP1 Antibodies) and APLP2, behave similarly to APP (show APP Antibodies) in that they both associate with assembled NMDA receptors in the endoplasmic reticulum
our discoveries establish a role for APLP2 in the growth of pancreatic cancer cells and show that inhibitors preventing APLP2 cleavage reduce the viability of pancreatic cancer cells.
amyloid precursor protein-like (show APP Antibodies) protein-2, but not amyloid precursor protein (show APP Antibodies), is involved in mediating postendocytic delivery of PCSK9 (show PCSK9 Antibodies) to lysosomes and is therefore important for PCSK9 (show PCSK9 Antibodies) function
Aberrant enhancement of YWK-II/APLP2 by nuclear export of Bat3 (show BAT3 Antibodies) may play a role in cancer development by inhibiting cell apoptosis.
APP (show APP Antibodies) and its mammalian homologs, amyloid precursor-like proteins APLP1 (show APLP1 Antibodies) and APLP2, participate under physiological conditions via trans-cellular dimerization in synaptogenesis.
APLP-2 (and APLP1 (show APLP1 Antibodies)) are capable of activating gene transcription via binding to Mint3 (show APBA3 Antibodies).

Mouse (Murine) Amyloid beta (A4) Precursor-Like Protein 2 (APLP2) interaction partners

APLP2 couples retina development and synaptic genes and present the first evidence that APLP2 expression may be linked to synaptic disease.
These data support the notion that APP (show APP Antibodies) and APLP2 facilitate transmitter release, likely through the interaction with the neurotransmitter release machinery.
This paper demonstrates an important role for APLP2 in refractive development in mice and humans, suggesting a high level of evolutionary conservation of the signaling pathways underlying refractive eye development.
Study provides compelling evidence for an essential role of both APP (show APP Antibodies) and APLP2 for neuronal and synaptic morphology as well as hippocampal function and suggest an acute and specific function of endogenous APPsalpha to facilitate synaptic plasticity
The study investigates the subcellular distribution patterns of the metal ions Cu, Zn, Fe, and Ca in individual neurons derived from APP (show APP Antibodies) and APLP2 knockout mice brains to further define their role in metal homeostasis.
This study further highlights the distinct and essential role of APLP2 at NMJ synapses that cannot be compensated by APP (show APP Antibodies).
Amyloid precursor protein (APP)/APP-like (show APP Antibodies) protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome
The study investigated copper, iron, zinc and manganese levels in APP (show APP Antibodies) and APLP-2 single knockout mice as well as homozygous:hemizygous knockout mice at 3, 12 and 18 plus months of age.
Data reveal that APLP2 is specifically required for proper cell cycle exit of neuronal progenitors, and thus has a distinct role in priming cortical progenitors for neuronal differentiation.
APLP2 and the intracellular domain of APP (show APP Antibodies) are not essential for coherent activity patterns in the hippocampus, but have subtle effects on synaptic plasticity and fine-tuning of network oscillations.

Zebrafish Amyloid beta (A4) Precursor-Like Protein 2 (APLP2) interaction partners

these results indicate the Appa (show APP Antibodies)-RFP (show MKRN1 Antibodies) and Aplp2 fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.

Amyloid beta (A4) Precursor-Like Protein 2 (APLP2) Antigen Profile

Antigen Summary

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with Amyloid beta (A4) Precursor-Like Protein 2 (APLP2)

amyloid beta precursor like protein 2 (APLP2) antibody
amyloid beta (A4) precursor-like protein 2 (Aplp2) antibody
amyloid beta precursor like protein 2 (Aplp2) antibody
amyloid beta (A4) precursor-like protein 2 S homeolog (aplp2.S) antibody
amyloid beta (A4) precursor-like protein 2 (aplp2) antibody
amyloid beta (A4) precursor-like protein 2 L homeolog (aplp2.L) antibody
amyloid beta precursor like protein 2 (aplp2) antibody

AI790698 antibody
APLP-2 antibody
APLP2 antibody
aplp2 A antibody
aplp2 B antibody
Apph antibody
APPL2 antibody
CDEBP antibody
MGC86389 antibody
si:dkey-11k4.3 antibody
WALPLP2 antibody

Protein level used designations for APLP2

CDEI box-binding protein , amyloid precursor protein homolog HSD-2 , amyloid-like protein 2 , CDEBP , Amyloid protein precursor-like protein 2 , amyloid beta (A4) precursor-like protein 2-like , sperm membrane protein (YWK-II) , sperm membrane protein YWK-II , amyloid beta (A4) precursor-like protein 2 , amyloid-beta-like protein B , suppression of tumorigenicity 14 , amyloid-like protein 2-like , amyloid-beta-like protein A

GENE ID	SPECIES
334	Homo sapiens
11804	Mus musculus
64312	Rattus norvegicus
431789	Xenopus laevis
479393	Canis lupus familiaris
718819	Macaca mulatta
741867	Pan troglodytes
785005	Bos taurus
796801	Danio rerio
100072668	Equus caballus
100126835	Sus scrofa
100358231	Oryctolagus cuniculus
100380132	Xenopus (Silurana) tropicalis
100414190	Callithrix jacchus
100470064	Ailuropoda melanoleuca
431790	Xenopus laevis
100557178	Anolis carolinensis
419727	Gallus gallus

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Show all anti-Amyloid beta (A4) Precursor-Like Protein 2 (APLP2) Antibodies with Pubmed References