APLP2 antibody (C-Term)

Catalog No. ABIN950473

This Rabbit Polyclonal antibody specifically detects APLP2 in WB and EIA. It exhibits reactivity toward Human and Mouse.It has been mentioned in 1 publication

Quick Overview for APLP2 antibody (C-Term) (ABIN950473)

Target: APLP2 (Amyloid beta (A4) Precursor-Like Protein 2 (APLP2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APLP2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-APLP2 Antibody

Binding Specificity: AA 592-621, C-Term

Specificity: This antibody reacts to APPL2.

Cross-Reactivity (Details): Species reactivity (tested):Human and Mouse.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 592-621 amino acids from the C-terminal region of human APLP2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-APLP2 antibody (ABIN950473)

Tuli, Sharma, McIlhaney, Talmadge, Naslavsky, Caplan, Solheim: "Amyloid precursor-like protein 2 increases the endocytosis, instability, and turnover of the H2-K(d) MHC class I molecule." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 3, pp. 1978-87, (2008) (PubMed).

Target Details for APLP2

Target: APLP2 (Amyloid beta (A4) Precursor-Like Protein 2 (APLP2))

Alternative Name: APPL2 / APLP2

Background: APLP2 may play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.Synonyms: APPH, Amyloid protein homolog, Amyloid-like protein 2, CDEBP, CDEI box-binding protein

Gene ID: 334

NCBI Accession: NP_001135748

Pathways: EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Feeding Behaviour