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Data showed that chronic myeloid leukemia (show BCL11A Proteins) (CML (show BCR Proteins)) patients expressed a higher level of EPS8 mRNA in bone marrow mononuclear cells. Functional results revealed that EPS8 regulated multiple biological functions such as proliferation, apoptosis, cell cycle, drug sensitivity of CML (show BCR Proteins) cells possibly by mediating the regulation of the BCR-ABL (show ABL1 Proteins)/AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signalling pathway.
These results indicate that plasma-membrane-associated PTK6 (show PTK6 Proteins) phosphorylates Eps8, which promotes cell proliferation, adhesion, and migration
Eps8/Abi1 (show ABI1 Proteins)/Sos1 (show SOS1 Proteins) tricomplex acts as a key molecular switch altering the balance between Rac1 and Rho activation; its presence or absence in pancreatic ductal adenocarcinoma cells modulates alphavbeta6-dependent functions, resulting in a pro-migratory (Rac1-dependent) or a pro-TGF-beta1 (show TGFB1 Proteins) activation (Rho-dependent) functional phenotype
Immunohistochemistry revealed that Eps8 was significantly increased in cervical cancer specimens compared with squamous intraepithelial lesion and normal cervical tissues. Additionally, it was revealed that Eps8 expression not only correlated with cervical cancer progression, but also exhibited a close correlation with the epithelialmesenchymal transition (EMT (show ITK Proteins)) markers, Ecadherin and vimentin (show VIM Proteins).
Eps8 is required for continuous membrane blebbing.
Erk (show EPHB2 Proteins) activity promotes actin bundling by Eps8 to enhance cortex tension and drive the bleb-based migration of cancer cells under non-adhesive confinement.
Eps8 is a crucial mediator of Src (show SRC Proteins)- and FAK (show PTK2 Proteins)-regulated processes.
Eps8 is overexpressed in human breast cancers, possibly by regulating ERK (show EPHB2 Proteins) signaling, MMP9 (show MMP9 Proteins), p53 (show TP53 Proteins) and EMT (show ITK Proteins)-like transition to affect breast cancer cell growth, migration and invasion.
EPS8, as MDR1 and WT1 (show WT1 Proteins), may be a clinically valuable biomarker for assessing the outcome of ALL patients.
These results indicate that employing the native and modified epitopes identified here in Eps8-based immunotherapy for HLA-A2.1 positive cancer patients may result in efficient anticancer immune responses for diverse tumor types.
Absence of Eps8 produces a weaker phenotype in vestibular hair cells compared to cochlear inner hair cells, since it affects the hair bundle morphology but not the basolateral membrane currents. This difference is likely to explain the absence of obvious vestibular dysfunction in Eps8 knockout mice.
Results implicate N-methyl-d-aspartate receptor (show GRIN1 Proteins) hyperfunction in the cognitive deficits observed in Epidermal growth factor receptor (show EGFR Proteins) substrate 8 (Eps8) knockout mice and demonstrate a novel role for Eps8 in regulating hippocampal long-term synaptic plasticity and cognitive function.
These findings demonstrate a novel role for Wnt (show WNT2 Proteins)-Dvl1 (show DVL1 Proteins) signalling through Eps8 in the regulation of axonal remodeling.
It shows that EPS8, a signaling adapter regulating actin dynamics, is a novel partner of VE-cadherin (show CDH5 Proteins) and is able to modulate YAP (show YAP1 Proteins) activity.
The actin-binding proteins eps8 and gelsolin (show GSN Proteins) have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells.
These results reveal a previously unknown cell type-specific expression pattern of endogenous Eps8 protein in the mouse hippocampus.
the key role of Eps8 actin-capping activity in spine morphogenesis and plasticity and indicate that reductions in actin-capping proteins may characterize forms of intellectual disabilities associated with spine defects.
identified Eps8 as a unique actin capping protein (show TMOD4 Proteins) specifically required for Dendritic cell migration
epidermal growth factor receptor pathway substrate 8 is critical in coordinating the development and functionality of mammalian auditory hair cells
critical role for JNK2 (show MAPK9 Proteins) and EPS8 in receptor tyrosine kinase (show ERBB3 Proteins) signaling and trafficking to convey distinctly different effects on cell migration.
the SSC5:60296617 SNP may affect teat number by regulating the interaction of EPS8 and RAPGEF1 (show RAPGEF1 Proteins) and, finally, affecting the mammogenesis of pigs
Coexpression of ezrin with Eps8 promotes the formation of membrane ruffles and tufts of microvilli, whereas expression of ezrin and Eps8L1a induces the clustering of actin-containing structures at the cell surface.
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
epidermal growth factor receptor kinase substrate 8
, epidermal growth factor receptor pathway substrate 8