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We further demonstrated the suppressive function of lncRNA#32 in hepatitis B virus and hepatitis C virus infection. lncRNA#32 bound to activating transcription factor 2 (ATF2 (show ATF2 Proteins)) and regulated ISG expression. Our results reveal a role for lncRNA#32 in host antiviral responses.
These results indicate that plasma-membrane-associated PTK6 (show PTK6 Proteins) phosphorylates Eps8, which promotes cell proliferation, adhesion, and migration
Results show that ATF2 (show ATF2 Proteins) is highly expressed in renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)) tissues and promotes RCC (show XRCC1 Proteins) cell proliferation, migration and invasion. The study suggests that ATF2 (show ATF2 Proteins) exerts an oncogenic role in RCC (show XRCC1 Proteins).
These findings point to an oncogenic function for ATF2 (show ATF2 Proteins) in melanoma development that appears to be independent of its transcriptional activity.
this study demonstrates that CPEB2 (show CPEB2 Proteins) alternative splicing is a major regulator of key cellular pathways linked to anoikis resistance and metastasis.
Eps8/Abi1 (show ABI1 Proteins)/Sos1 (show SOS1 Proteins) tricomplex acts as a key molecular switch altering the balance between Rac1 and Rho activation; its presence or absence in pancreatic ductal adenocarcinoma cells modulates alphavbeta6-dependent functions, resulting in a pro-migratory (Rac1-dependent) or a pro-TGF-beta1 (show TGFB1 Proteins) activation (Rho-dependent) functional phenotype
Noxin facilitated the expression of Cyclin D1 (show CCND1 Proteins) and Cyclin E1 (show CCNE1 Proteins) through activating P38 (show CRK Proteins)-activating transcription factor 2 (show ATF2 Proteins) signaling pathway, thus enhanced cell growth of breast cancer
these observations suggest that CD99 (show CD99 Proteins) is involved in the regulation of CD1a (show CD1A Proteins) transcription and expression by increasing ATF-2 (show ATF2 Proteins).
This review provides an overview of the currently known upstream regulators and downstream targets of ATF2 (show ATF2 Proteins). [review]
TNF (show TNF Proteins) induces the binding of ATF2 (show ATF2 Proteins) to the TNF (show TNF Proteins)-responsive element.
Absence of Eps8 produces a weaker phenotype in vestibular hair cells compared to cochlear inner hair cells, since it affects the hair bundle morphology but not the basolateral membrane currents. This difference is likely to explain the absence of obvious vestibular dysfunction in Eps8 knockout mice.
Results implicate N-methyl-d-aspartate receptor (show GRIN1 Proteins) hyperfunction in the cognitive deficits observed in Epidermal growth factor receptor (show EGFR Proteins) substrate 8 (Eps8) knockout mice and demonstrate a novel role for Eps8 in regulating hippocampal long-term synaptic plasticity and cognitive function.
These findings demonstrate a novel role for Wnt (show WNT2 Proteins)-Dvl1 (show DVL1 Proteins) signalling through Eps8 in the regulation of axonal remodeling.
It shows that EPS8, a signaling adapter regulating actin dynamics, is a novel partner of VE-cadherin (show CDH5 Proteins) and is able to modulate YAP (show YAP1 Proteins) activity.
The actin-binding proteins eps8 and gelsolin (show GSN Proteins) have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells.
These results reveal a previously unknown cell type-specific expression pattern of endogenous Eps8 protein in the mouse hippocampus.
the key role of Eps8 actin-capping activity in spine morphogenesis and plasticity and indicate that reductions in actin-capping proteins may characterize forms of intellectual disabilities associated with spine defects.
identified Eps8 as a unique actin capping protein (show TMOD4 Proteins) specifically required for Dendritic cell migration
epidermal growth factor receptor pathway substrate 8 is critical in coordinating the development and functionality of mammalian auditory hair cells
critical role for JNK2 (show MAPK9 Proteins) and EPS8 in receptor tyrosine kinase (show ERBB3 Proteins) signaling and trafficking to convey distinctly different effects on cell migration.
the SSC5:60296617 SNP may affect teat number by regulating the interaction of EPS8 and RAPGEF1 (show RAPGEF1 Proteins) and, finally, affecting the mammogenesis of pigs
Coexpression of ezrin with Eps8 promotes the formation of membrane ruffles and tufts of microvilli, whereas expression of ezrin and Eps8L1a induces the clustering of actin-containing structures at the cell surface.
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
, activating transcription factor 2 splice variant ATF2-var2
, cAMP response element-binding protein CRE-BP1
, cAMP responsive element binding protein 2, formerly
, cAMP-dependent transcription factor ATF-2
, cAMP-responsive element-binding protein 2
, cyclic AMP-dependent transcription factor ATF-2
, cyclic AMP-responsive element-binding protein 2
, epidermal growth factor receptor kinase substrate 8
, epidermal growth factor receptor pathway substrate 8