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This study provides evidence of a possible role of NCK2 as biomarker of ovarian cancer progression.
There was no difference in the Nck2 mRNA expression between the SLE patients and the healthy subjects.
Nck1 (show NCK1 Proteins) and Nck2 Interact with WTIP (show WTIP Proteins). Nck1 (show NCK1 Proteins)/2 integrates nephrin (show NPHS1 Proteins) with the Hippo kinase cascade through association with the adaptor protein WTIP (show WTIP Proteins).
Data suggest that PINCH1 (show LIMS1 Proteins) and Nck2 critically participate in the regulation of cellular radiosensitivity and EGFR (show EGFR Proteins) function and downstream signaling in a cellular model of human squamous cell carcinoma.
Tir-Intimin interaction recruits the Nck adaptor to a Tir tyrosine phosphorylated residue where it activates neural Wiskott-Aldrich syndrome protein (N-WASP).
Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics.
NCK2 is involved in the susceptibility to opiates addiction.
The hNck2 SH3 domain (show ITSN1 Proteins) also exhibited pH dependent monomer-dimer transition.
Data show that both HK2 (show HK2 Proteins) and NCK2 are expressed in the retinal ganglion cell layer.
Nck2 effectively influences human melanoma phenotype progression.
Authors propose that Nck2 should be further investigated as a regulator of the reliance of white adipose tissue on hyperplasia versus hypertrophy during adipose tissue expansion, and hence, as a potential novel molecular target in obesity.
Findings reveal that Nck2 is a novel regulator of adiposity and suggest that Nck2 is important in limiting WAT expansion and dysfunction in mice and humans.
Inactivation of NCK2 (and NCK1 (show NCK1 Proteins)) inhibits endothelial cell polarity.
These results reveal that Nck (show NCK1 Proteins) regulates preosteoblastic/osteoblastic migration and bone mass.
we show that the non-catalytic region of tyrosine kinase (show NCK1 Proteins) adaptor (NCK (show NCK1 Proteins)) proteins 1 and 2 are distributed in the developing spinal cord
Mouse embryos lacking endothelial Nck1 (show NCK1 Proteins)/2 expression develop extensive angiogenic defects that result in lethality at about embryonic day 10.
Data show that only Nck2 is required for the Slit1 (show SLIT1 Proteins)-induced changes in cortical neuron morphology in vitro.
These results revealed an essential role for HSF4-mediated SKAP2 expression in the regulation of actin reorganization during lens differentiation.
The Cas (show CTNND1 Proteins) utilizes Nck2 to activate Cdc42 (show CDC42 Proteins) and induce cell polarization in response to wound healing.
Nck1 (show NCK1 Proteins) and Nck2 have roles in cell movement and cytoskeletal organization
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
SH2/SH3 adaptor protein NCK-beta
, cytoplasmic protein NCK2
, growth factor receptor-bound protein 4
, noncatalytic region of tyrosine kinase, beta
, non-catalytic region of tyrosine kinase adaptor protein 2
, NCK adaptor protein 2
, cytoplasmic protein NCK2-like