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anti-Human AMFR Antibodies:
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Human Polyclonal AMFR Primary Antibody for Func, IHC - ABIN4280243
Lucarelli, Galleggiante, Rutigliano, Sanguedolce, Cagiano, Bufo, Lastilla, Maiorano, Ribatti, Giglio, Serino, Vavallo, Bettocchi, Selvaggi, Battaglia, Ditonno: Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma. in Oncotarget 2015
Show all 2 Pubmed References
Human Polyclonal AMFR Primary Antibody for IHC - ABIN965545
Shimizu, Tani, Watanabe, Nagamachi, Niinaka, Shiroishi, Ohwada, Raz, Yokota: The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. in FEBS letters 1999
Show all 2 Pubmed References
Human Polyclonal AMFR Primary Antibody for FACS, IHC (p) - ABIN388938
Huang, Xie, Raz: Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor. in Biochemical and biophysical research communications 1995
Show all 3 Pubmed References
This is the first study to show that HSPA1L (show HSPA1L Antibodies) mediated HIF-1alpha (show HIF1A Antibodies) stabilization. In addition, this is the first study to show that GP78 inactivation promotes cancer cell proliferation, migration and eventual tumor growth both in vivo and in vitro by increasing cellular prion protein (show PRNP Antibodies).
overexpression of gp78 or SVIP suppression may eliminate the toxic gain of function associated with polymerization of ZAAT, thus providing a potential new therapeutic approach to the treatment of alpha-1 antitrypsin (show SERPINA1 Antibodies) deficiency
Despite its interaction with gp78, Lnp does not seem to have a broad function in degradation of misfolded ER proteins.
Further study discovered that the gp78 CUE domain works as a proofreading machine during the growth of K48-linked polyubiquitin (show UBB Antibodies) chains to ensure the linkage specificity. Together, our studies uncover a novel mechanism underlying the linkage specificity determination of longer polyubiquitin (show UBB Antibodies) chains.
AMFR expression is significantly reduced in plasma from osteoporosis patients.
Catalytic inactivation of MGRN1 (show MGRN1 Antibodies) results in elevated levels of GP78 and a consequential increase in the initiation of mitophagy.
Authors conclude that the Hrd1 (show SYVN1 Antibodies) complex forms an essential retrotranslocation module that is evolutionarily conserved, but the mammalian ERAD system uses additional ubiquitin ligases to assist Hrd1 (show SYVN1 Antibodies) during retrotranslocation.
Downregulation of AMFR induced cell cycle arrest at the G0/G1 phase, and increased apoptosis of the THP1 (show GLI2 Antibodies) cells.
The authors identify USP13 (show USP13 Antibodies) as a gp78-associated deubiquitinase that eliminates ubiquitin conjugates from Ubl4A (show UBL4A Antibodies) to maintain the functionality of Bag6 (show BAT3 Antibodies).
Data show that autocrine motility factor receptor (AMFR) and NOTCH1 (show NOTCH1 Antibodies) protein are the direct target genes of microRNA miR (show MLXIP Antibodies)-139-5p in colorectal cancer (CRC (show CALR Antibodies)).
Gp78, an E3 ubiquitin ligase (show MUL1 Antibodies) acts as a gatekeeper suppressing nonalcoholic steatohepatitis (NASH (show SAMSN1 Antibodies)) and liver cancer.
The ubiquitin ligase (show RNF123 Antibodies) gp78, known for its role in protein quality control, is critical for unglycosylated PrP ubiquitylation and degradation.
we consistently observe involvement of gp78 in Insig-1 (show INSIG1 Antibodies) degradation, we find no substantive evidence to support roles for either gp78 or TRC8 (show RNF139 Antibodies) in the robust sterol-accelerated degradation of HMG-CoA reductase (show HMGCR Antibodies)
Ablation of gp78 in liver improves hyperlipidemia and insulin (show INS Antibodies) resistance by inhibiting SREBP to decrease lipid biosynthesis.
Palmitoylation of RING finger (show PCGF1 Antibodies) cysteines therefore regulates gp78 distribution to the peripheral ER
AMFR is involved in the process of learning and memory in the central nervous system.
KAI1 has a role in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase
Gp78 promotes SOD1 (show SOD1 Antibodies) and ataxin-3 (show ATXN3 Antibodies) degradation in endoplasmic reticulum.
cytoplasmic protein (show BLZF1 Antibodies) mouse p97 (show EIF4G2 Antibodies)(mp97) participates in the formation of a ternary complex containing mouse autocrine motility factor receptor (mAMFR), mp97, and peptide N-glycanase
the receptor molecule for AMF/NLK/MF in leukemic differentiation is not gp78
gp78 plays a critical role in protecting against ER stress in liver
This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins.
E3 ubiquitin-protein ligase AMFR
, RING finger protein 45
, AMF receptor
, autocrine motility factor receptor
, autocrine motility factor receptor, amfr
, autocrine motility factor receptor amfr
, autocrine motility factor receptor, isoform 2-like