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Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice
Study describes a potentially protective role for Derl3 in the heart.
DERL3 promotes malignant phenotype in BC cells.
SLC2A1 overexpression mediated by DERL3 epigenetic loss contributes to the Warburg effect.
Findings indicate that Derlin-3 provides the missing link between EDEM and p97 in the process of degrading misfolded glycoproteins.
The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Der1-like domain family, member 3
, derlin-3 protein
, putative carcinoma related gene variant 3
, degradation in endoplasmic reticulum protein 3
, der1-like protein 3
, DERtrin 3