Derlin-3 antibody (Middle Region)

Catalog No. ABIN2781868

The Rabbit Polyclonal anti-Derlin-3 antibody is suitable to detect Derlin-3 in samples from Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Horse and Goat. It has been validated for WB.

Quick Overview for Derlin-3 antibody (Middle Region) (ABIN2781868)

Target: Derlin-3 (DERL3) (Der1-Like Domain Family, Member 3 (DERL3))

Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Zebrafish (Danio rerio), Horse, Goat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Derlin-3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Derlin-3 Antibody

Binding Specificity: Middle Region

Purpose: DERL3 Antibody - middle region

Sequence: FFFNMLFVFR YCRMLEEGSF RGRTADFVFM FLFGGVLMTL LGLLGSLFFL

Predicted Reactivity: Cow: 100%, Dog: 100%, Goat: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Characteristics: This is a rabbit polyclonal antibody against DERL3. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human DERL3

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44442-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for Derlin-3

Target: Derlin-3 (DERL3) (Der1-Like Domain Family, Member 3 (DERL3))

Alternative Name: DERL3

Background:

Background Information: DERL3 belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Gene Name: Der1-like domain family, member 3

Alternative Symbols: IZP6, LLN2, C22orf14, derlin-3

Protein Name: Derlin-3

Molecular Weight: 27kDa

Gene ID: 91319

NCBI Accession: NP_001002862

UniProt: Q96Q80

Pathways: ER-Nucleus Signaling