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mTORC2 (show CRTC2 Proteins) responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1, and is essential for proper expression and nuclear accumulation of the GFAT1 transcriptional regulator, Xbp1s.
GFAT-1 plays a critical role in modulating adipogenesis
high GFAT1 expression is identified as an independent predictor of adverse clinical outcome in our small number of pancreatic cancer patients, and the practical prognostic nomogram model may help clinicians in decision making and the design of clinical studies.
study reports nine new mutations of GFPT1 in limb-girdle congenital myasthenic syndrome (LG-CMS (show Cd2ap Proteins))
Findings indicate that GFAT1 functions as a novel suppressor of EMT (show ITK Proteins) and tumor metastasis in gastric cancer.
GNPDA1 (show GNPDA1 Proteins) siRNA induced GFAT2 which was hardly measurable in these cells under standard culture conditions, GNPDA2 (show GNPDA2 Proteins) siRNA increased GFAT1, and GFAT1 siRNA increased the expression of hyaluronan synthase 2 (HAS2 (show HAS2 Proteins)). Silencing of GFAT1 stimulated GNPDA1 (show GNPDA1 Proteins) and GDPDA2, and inhibited cell migration.
High GFAT1 expression is associated with hepatocellular carcinoma.
GFAT1 phosphorylation by AMPK (show PRKAA1 Proteins) promotes VEGF (show VEGFA Proteins)-induced angiogenesis.
The AMPK (show PRKAA1 Proteins)-GFAT1 signaling axis serves as an important communication point between two nutrient-sensitive signaling pathways and is likely to play a significant role in controlling physiological processes in many other tissues.
Increased GFPT1 expression is associated with triple-negative breast cancer.
This study demonstrated that Congenital myasthenic syndrome with tubular aggregates caused by GFPT1 mutations.
Data suggest that enzymes in hexosamine biosynthesis pathway and downstream protein O-GlcNAcylation are important for preimplantation development; these include Gfpt, Oga (O-GlcNAcase), and Ogt (O-GlcNAc transferase).
cDNA sequence of the porcine GFAT1 gene was cloned and a GFAT1 splice variant (designed GFAT1-L) that contains a 54 bp insertion within the coding region, was identified.
This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate.
glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1
, glutamine-fructose-6-phosphate transaminase 1
, glutamine--fructose-6-phosphate transaminase 1
, D-fructose-6-phosphate amidotransferase 1
, GFAT 1
, glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
, glutamine:fructose 6 phosphate amidotransferase 1
, glutamine:fructose-6-phosphate amidotransferase 1
, hexosephosphate aminotransferase 1
, glutamine fructose aminotransferase
, glutamine-fructose-6-phosphate aminotransferase 1