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anti-Human MBTPS1 Antibodies:
anti-Mouse (Murine) MBTPS1 Antibodies:
anti-Rat (Rattus) MBTPS1 Antibodies:
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In the absence of S1P, the catalytically inactive alpha/beta-subunit (show POLG Antibodies) precursor of GlcNAc-1-phosphotransferase fails to be activated and results in missorting of newly synthesized lysosomal enzymes, and lysosomal accumulation of non-degraded material, which are biochemical features of defective GlcNAc-1-phosphotransferase subunits and the associated pediatric lysosomal diseases mucolipidosis type II and III.
Results suggest that (pro)renin receptor (show ATP6AP2 Antibodies) (s(P)RR (show ATP6AP2 Antibodies)) is generated by sequential processing by site-1 protease (S1P) and furin (show FURIN Antibodies) protein.
primordial SKI-1/S1P likely contained a simpler prodomain consisting of the highly conserved AB fragment that represents an independent folding unit
S1P substrate-dependent regulatory mechanisms for lipid synthesis and biogenesis of lysosomes are different
The interaction between S1P and C5a plays an important role in neutrophils for antineutrophil cytoplasmic antibody -mediated activation
Incompletely matured forms of SKI-1/S1P further process cellular and viral substrates in distinct subcellular compartments.
We show that SKI-1 is constitutively expressed in human pigment cells with higher SKI (show SKI Antibodies) activity in seven out of eight melanoma cell lines compared with normal melanocytes.
Diabetic high-density lipoprotein carries higher levels of S1P compared with normal high-density lipoprotein.
Y285 of SKI-1 is crucial for the efficient processing of envelope glycoproteins from Old World and clade C New World arenavirus.
The role of MBTPS1 (SKI-1/S1P) peptides in cancer and approaches used to inhibit SKI-1/S1P were studied.
Data (including data from studies in knockout mice) suggest osteocyte Mbtps1 expression is involved in development of sarcopenia in slow-twitch muscle fibers; Mbtps1 knockout mice (conditional osteocyte deletion) do not develop sarcopenia of aging.
S1P (show S1PR1 Antibodies) substrate-dependent regulatory mechanisms for lipid synthesis and biogenesis of lysosomes are different
A novel role for MBTPS1/SKI-1/S1P (membrane bound transcription factor protease, subtilisin kexin isozyme-1, or site 1 protease) in somite segmentation and in the pathogenesis of vertebral anomalies.
These studies indicate an indispensable role for S1P in type IIB procollagen trafficking from the ER.
Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal mice.
Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner
the differentiated phenotype of osteoblastic cells and possibly osteocytes depends upon the non-apoptotic actions of SKI-1.
S1P (show S1PR1 Antibodies) affects and sustains all key cellular processes responsible for wound repair and point to a unique potential for this molecule in the therapy of diabetic wounds, particularly as an angiogenic agent in treatment of diabetic wounds.
Site-1 protease is essential for endochondral bone formation.
SKI-1 plays a direct or indirect role in assembly of functional nucleation complexes containing BAG-75 and BSP (show KLK6 Antibodies) and their fragments, thus facilitating initial mineral nucleation within these biomineralization foci.
The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein.
, membrane-bound transcription factor site-1 protease
, site-1 protease
, subtilisin/kexin isozyme-1
, S1P endopeptidase
, membrane-bound transcription factor protease, site 1
, sterol-regulated luminal protease
, subtilisin/kexin isozyme 1
, subtilisin/kexin isozyme SKI-1