MBTPS1 antibody (C-Term)

Catalog No. ABIN7180200

Product Details anti-MBTPS1 Antibody

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MBTPS1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity: Human, Mouse, Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human MBTPS1.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MBTPS1

Target: MBTPS1 (Membrane-Bound Transcription Factor Peptidase, Site 1 (MBTPS1))

Alternative Name: MBTPS1 (MBTPS1 Products)

Synonyms: PCSK8 antibody, S1P antibody, SKI-1 antibody, 0610038M03Rik antibody, AV003995 antibody, Ski1 antibody, mKIAA0091 antibody, S1p antibody, Ski-1 antibody, membrane bound transcription factor peptidase, site 1 antibody, membrane-bound transcription factor peptidase, site 1 antibody, MBTPS1 antibody, Mbtps1 antibody

Background:

Background: Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.

Nakajima T., J. Hum. Genet. 45:212-217(2000).
Nagase T., DNA Res. 2:37-43(1995).
Bechtel S., BMC Genomics 8:399-399(2007).

Aliases: MBTPS1 antibody, KIAA0091 antibody, S1P antibody, SKI1Membrane-bound transcription factor site-1 protease antibody, EC 3.4.21.112 antibody, Endopeptidase S1P antibody, Subtilisin/kexin-isozyme 1 antibody, SKI-1 antibody

UniProt: Q14703

Pathways: ER-Nucleus Signaling