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Human Polyclonal SYVN1 Primary Antibody for IF, IHC (p) - ABIN388980
Kaneko, Koike, Saito, Kitamura, Okuma, Nomura: Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Show all 11 Pubmed References
Human Polyclonal SYVN1 Primary Antibody for ICC, IF - ABIN250959
Soundararajan, Wang, Melters, Pearce: Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. in The Journal of biological chemistry 2010
Show all 8 Pubmed References
Human Polyclonal SYVN1 Primary Antibody for WB - ABIN1882139
Kikkert, Doolman, Dai, Avner, Hassink, van Voorden, Thanedar, Roitelman, Chau, Wiertz: Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. in The Journal of biological chemistry 2004
Show all 6 Pubmed References
Human Polyclonal SYVN1 Primary Antibody for WB - ABIN650702
Wang, Yu, Guo, Zuo, Fisher, Subjeck, Wang: Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination. in Journal of immunology (Baltimore, Md. : 1950) 2013
Show all 3 Pubmed References
Human Polyclonal SYVN1 Primary Antibody for IHC (fro), IF (p) - ABIN671811
Yan, Zheng, Chen, Liu, Li, Hu, Pei, Li: Expression of endoplasmic reticulum stress-related factors in the retinas of diabetic rats. in Experimental diabetes research 2011
Show all 2 Pubmed References
Human Polyclonal SYVN1 Primary Antibody for ICC, IF - ABIN4319847
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Human Polyclonal SYVN1 Primary Antibody for ELISA, IHC - ABIN4319849
Kaneko: [Possible involvement of HRD1 (ubiquitin E3 ligase) in neurodegenerative diseases]. in Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2009
Hrd1 is an E3 ubiquitin ligase in human T cells.IHrd1 expression is increased in CD4-positive T cells from multiple sclerosis patients.
HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF-2a ubiquitylation and degradation.
PADI4 (show PADI4 Antibodies) interacted with SYVN1 directly and that overexpression of PADI4 (show PADI4 Antibodies) suppressed the ubiquitination of proteins. Thus, a reduction in ER stress induced by PADI4 (show PADI4 Antibodies) may abrogate the initiation of chronic RA by suppressing the proliferative signals of RA synoviocytes.
Amyloid beta oligomers modulate BACE1 (show BACE Antibodies) through an XBP-1 (show XBP1 Antibodies)-dependent pathway involving HRD1.
findings support a model of Hrd1 complex formation, where the Hrd1 cytoplasmic domain and FAM8A1 have a central role in the assembly and activity of this ERAD machinery.
HSP70 (show HSP70 Antibodies)-Hrd1 axis represents a potential therapeutic target for restoring the oncorepressor activity of unstable lymphoma-associated Blimp-1 (show PRDM1 Antibodies) mutants.
this study proved that SYVN1 enhances SERPINA1 (show SERPINA1 Antibodies)(E342K)/ATZ degradation through SQSTM1 (show SQSTM1 Antibodies)-dependent autophagy and attenuates SERPINA1 (show SERPINA1 Antibodies)(E342K)/ATZ cytotoxicity.
Results demonstrated that overexpression of Hrd1 increased the proteasomal degradation and microtubule-dependent aggresome formation of OPTN (show OPTN Antibodies) in the microtubular organizing center, whereas knockdown of Hrd1 stabilized OPTN (show OPTN Antibodies) and inhibited aggresome formation of OPTN (show OPTN Antibodies).
Data show that E3 ubiquitin ligase (show MUL1 Antibodies) HRD1 (HRD1) decreased the protein level of S100A8 (show S100A8 Antibodies) through ubiquitination.
Analysis of affinity-captured Hrd1 complexes from these cells by size-exclusion chromatography, immunodepletion, and absolute quantification mass spectrometry identified two major high-molecular-mass complexes with distinct sets of interacting proteins and variable stoichiometries, suggesting a hitherto unrecognized heterogeneity in the functional units of Hrd1-mediated protein degradation.
Hrd1 is a positive regulator of T cells.Hrd1 is required for T-cell activation and differentiation.
Hrd1-null B cells exhibited high Fas (show FAS Antibodies) expression during activation and rapidly underwent Fas (show FAS Antibodies)-mediated apoptosis, which could be largely inhibited by FasL (show FASL Antibodies) neutralization. Fas (show FAS Antibodies) mutation in Hrd1 KO mice abrogated the increase in B-cell AICD. We identified Hrd1 as the first E3 ubiquitin ligase (show MUL1 Antibodies) of the death receptor Fas (show FAS Antibodies) and Hrd1-mediated Fas (show FAS Antibodies) destruction as a molecular mechanism in regulating B-cell immunity.
This study implicates Endoplasmic reticulum (ER)-associated degradation mediated by Sel1L (show SEL1L Antibodies)-Hrd1 as a key regulator of B cell development.
SYVN1 may play an important role in inhibiting ER stress, chronic inflammation, and vascular overgrowth associated with DR.
Data show that inositol requiring enzyme 1alpha (IRE1alpha (show ERN1 Antibodies)), the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L (show SEL1L Antibodies) proten-Hrd1 protein endoplasmic reticulum (ER)-associated degradation (ERAD) complex.
Hrd1 is an essential component of the adaptive endoplasmic reticulum stress response in cardiac myocytes.
The results highlight a novel function for SYVN1 in the control of body weight and mitochondrial biogenesis through negative regulation of PGC (show PGC Antibodies)-1b.
This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms.
E3 ubiquitin-protein ligase synoviolin
, HMG-coA reductase degradation 1 homolog
, synovial apoptosis inhibitor 1, synoviolin
, synoviolin 1
, HRD1 protein
, LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase synoviolin
, E3 ubiquitin-protein ligase synoviolin B
, RING-type E3 ubiquitin transferase synoviolin B
, Synovial apoptosis inhibitor 1-B
, synovial apoptosis inhibitor 1-B
, RING-type E3 ubiquitin transferase synoviolin