SYVN1 antibody (N-Term)

Catalog No. ABIN1882139

There are 6+ publications for this product available. The Rabbit Polyclonal anti-SYVN1 antibody is suitable to detect SYVN1 in samples from Human. It has been validated for WB.

Quick Overview for SYVN1 antibody (N-Term) (ABIN1882139)

Target: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYVN1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB5086

Product Details anti-SYVN1 Antibody

Binding Specificity: AA 58-88, N-Term

Predicted Reactivity: M, X

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SYVN1 (HRD1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-88 amino acids from the N-terminal region of human SYVN1 (HRD1).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SYVN1 antibody (ABIN1882139)

Smith, Granell, Salcedo-Sicilia, Baldini, Egea, Teckman, Baldini: "Activating transcription factor 6 limits intracellular accumulation of mutant ?(1)-antitrypsin Z and mitochondrial damage in hepatoma cells." in: The Journal of biological chemistry, Vol. 286, Issue 48, pp. 41563-77, (2011) (PubMed).

Klemm, Spooner, Ploegh: "Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control." in: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37602-14, (2011) (PubMed).

Huang, Marvin, Tatsis, Eisenlohr: "Cutting Edge: Selective role of ubiquitin in MHC class I antigen presentation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 4, pp. 1904-8, (2011) (PubMed).

Kikkert, Doolman, Dai, Avner, Hassink, van Voorden, Thanedar, Roitelman, Chau, Wiertz: "Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum." in: The Journal of biological chemistry, Vol. 279, Issue 5, pp. 3525-34, (2004) (PubMed).

Amano, Yamasaki, Yagishita, Tsuchimochi, Shin, Kawahara, Aratani, Fujita, Zhang, Ikeda, Fujii, Miura, Komiya, Nishioka, Maruyama, Fukamizu, Nakajima: "Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy." in: Genes & development, Vol. 17, Issue 19, pp. 2436-49, (2003) (PubMed).

Nadav, Shmueli, Barr, Gonen, Ciechanover, Reiss: "A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1." in: Biochemical and biophysical research communications, Vol. 303, Issue 1, pp. 91-7, (2003) (PubMed).

Target Details for SYVN1

Target: SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

Alternative Name: SYVN1 (HRD1)

Background: HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Synoviolin/Hrd1 (expressed in rheumatoid synovium) is reported to be a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.

Molecular Weight: 67685

NCBI Accession: NP_115807, NP_757385

UniProt: Q86TM6

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling