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Human Polyclonal vcp Primary Antibody for ICC, IF - ABIN151102
Clemen, Tangavelou, Strucksberg, Just, Gaertner, Regus-Leidig, Stumpf, Reimann, Coras, Morgan, Fernandez, Hofmann, Müller, Schoser, Hanisch, Rottbauer, Blümcke, von Hörsten, Eichinger, Schröder: Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases. in Brain : a journal of neurology 2010
Show all 6 Pubmed References
Human Polyclonal vcp Primary Antibody for ICC, IF - ABIN151101
Dong, Bridges, Apsley, Xu, Weaver: ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. in Molecular biology of the cell 2008
Show all 4 Pubmed References
Xenopus laevis Monoclonal vcp Primary Antibody for WB - ABIN284668
Baron, Pedrioli, Tyagi, Johnson, Wood, Fountaine, Wightman, Alexandru: VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase. in BMC biology 2014
Show all 3 Pubmed References
Xenopus laevis Monoclonal vcp Primary Antibody for WB - ABIN933553
Ernst, Mueller, Ploegh, Schlieker: The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. in Molecular cell 2009
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Human Monoclonal vcp Primary Antibody for WB - ABIN1944899
Hu, Han, Song, Peng, Huang, Ren, Gu, Huang, Li, Jiang, Fu, Zhang, Gu, Dai, Mao, Gao, Rong, Ye, Zhou, Xu, Gu, Shi, Jin, Zhang, Wu, Huang, Chen, Chen, Chen: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. in Proceedings of the National Academy of Sciences of the United States of America 2000
Show all 3 Pubmed References
Human Polyclonal vcp Primary Antibody for FACS, IHC (p) - ABIN390907
Rush, Moritz, Lee, Guo, Goss, Spek, Zhang, Zha, Polakiewicz, Comb: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. in Nature biotechnology 2005
Show all 2 Pubmed References
Human Monoclonal vcp Primary Antibody for ICC, FACS - ABIN269087
Greenhalgh, Griffith, Wald: The use of immunofluorescence in microdissection testicular sperm extraction. in Journal of andrology 2009
Human Monoclonal vcp Primary Antibody for FACS, ICC - ABIN265891
Sullivan, Funk, Shan, Haroutunian, McCullumsmith: Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia. in PLoS ONE 2015
Study results suggest that VCP recruitment to mitochondria by mtHtt is a crucial step in the initiation of neuropatholo (show HTT Antibodies)gy in Huntington's disease.
ASPL (show ASPSCR1 Antibodies) efficiently promotes p97 (show EIF4G2 Antibodies) hexamer disassembly, resulting in the formation of stable p97 (show EIF4G2 Antibodies):ASPL (show ASPSCR1 Antibodies). Overproduction of ASPL (show ASPSCR1 Antibodies) disrupts p97 (show EIF4G2 Antibodies) hexamer function in endoplasmic reticulum-associated protein degradation.
Data indicate that approximately 9% of patients with valosin-containing protein (VCP) mutations had an amyotrophic lateral sclerosis (ALS (show IGFALS Antibodies)) phenotype, 4% had been diagnosed with Parkinson's disease (PD), and 2% had been diagnosed with Alzheimer's disease (AD).
CB-5083 decreases viability in multiple myeloma cell lines and patient-derived multiple myeloma cells, including those with background proteasome inhibitor (PI) resistance. CB-5083 has a unique mechanism of action that combines well with PIs (show CDIPT Antibodies), which is likely owing to the p97 (show EIF4G2 Antibodies)-dependent retro-translocation of the transcription factor, Nrf1 (show NFE2L1 Antibodies), which transcribes proteasome subunit genes following exposure to a PI
a p97 (show EIF4G2 Antibodies) mutant that causes inclusion body myopathy, Paget's disease of bone, and frontotemporal dementia unfolds substrate faster, suggesting that excess activity may underlie pathogenesis
Results report that VCP/p97 promotes the degradation of ubiquitylated GS, resulting in its accumulation in cells with compromised p97 (show EIF4G2 Antibodies) function. Notably, p97 (show EIF4G2 Antibodies) is also required for the degradation of all four known CRBN (show CRBN Antibodies) neo-substrates [IKZF1 (show IKZF1 Antibodies), IKZF3 (show IKZF3 Antibodies), CK1alpha (show CSNK1A1 Antibodies), and GSPT1 (show GSPT1 Antibodies)] whose ubiquitylation is induced by immunomodulatory drugs.
non-cell-autonomous effects of VCP-mutant astrocytes on both control and mutant Motor neurons, were examined.
AAA-ATPase p97 suppresses apoptotic and autophagy-associated cell death in rheumatoid arthritis synovial fibroblasts.
Data suggest ATXN3 (show ATXN3 Antibodies) binds with low-micromolar affinity to both wild-type p97/VCP and mutants linked to proteostasis deficiency multisystem proteinopathy 1 (MSP1; also called hereditary inclusion body myopathy); stoichiometry of binding is one ATXN3 (show ATXN3 Antibodies) molecule per p97/VCP hexamer in presence of ATP; MSP1 mutants of p97/VCP bind ATXN3 (show ATXN3 Antibodies) irrespective of nucleotide state. (VCP = valosin-containing protein/ATPase (show DNAH8 Antibodies); ATXN3 (show ATXN3 Antibodies) = ataxin-3 (show ATXN3 Antibodies))
a substantial proportion of the beta2AR (show ADRB2 Antibodies) produced is non-functional and VCP plays a key role in the maturation and trafficking of the beta2AR (show ADRB2 Antibodies).
VCP removes sterically trapped Ku70/80 rings from DNA in double-strand break repair.
Findings indicate that p97 plays a conserved role in dismantling the CMG (show CASK Antibodies) helicase (show DNA2 Antibodies) complex during different cellular events, but that distinct regulatory signals ultimately control when and where unloading takes place.
p97 is an essential regulator of DNA damage-dependent CDT1 (show CDT1 Antibodies) destruction
CDC-48/p97 coordinates CDT-1 (show CDT1 Antibodies) degradation with GINS chromatin dissociation to ensure faithful DNA replication
data reveal an essential pathway that regulates reformation of the nucleus after mitosis and defines ubiquitin-dependent protein extraction as a common mechanism of Cdc48/p97 activity also during nucleus formation
When we introduced CDC48 antisense morpholino oligonucleotides into zebrafish embryos, the morphant embryos were lethal and showed defects in neuronal outgrowth and neurodegeneration.
CDC48 may promote cell cycling and cell proliferation via C-terminal tyrosine phosphorylation during cold acclimation in fish cells
Study reports for the first time that VCP is aberrantly translocated to the mitochondria and bound to mutant Huntingtin (show HTT Antibodies) in a variety of Huntington's disease models.
Valosin-containing protein is a novel repressor of cardiomyocyte hypertrophy induced by pressure overload.
Together, these results suggested that mouse mammary tumor virus Rem (show REM1 Antibodies) uses a novel p97 (show EIF4G2 Antibodies)-dependent, Derlin-independent retrotranslocation mechanism distinct from other pathogens to avoid signal peptide ubiquitylation and proteasomal degradation.
cellular phenotypes caused by P137L mutant expression were not isolated observations, and some other IBMPFD disease-related VCP/p97 mutations could lead to similar outcomes
The functional motions of p97 (show EIF4G2 Antibodies) using symmetric normal modes have been predicted.
results suggest that (i) NLRP3 inflammasome and local IL-1beta((+))F4/80((+))Ly6C((+)) inflammatory macrophages contribute to pathogenesis of VCP-associated myopathy
VCP (valosin-containing protein), together with its cofactor P47 (show MFGE8 Antibodies) and the endoplasmic reticulum (ER) morphology regulator ATL1 (Atlastin-1 (show ATL1 Antibodies)), regulates tubular ER formation
Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice
Global expression profiling of VCP(R155H/+) mice identified key dysregulated signaling pathways including genes involved in the physiological system development and function, diseases and disorders, and molecular and cellular functions.
The results reveal an unexpected, crucial role of ATP consumption by VCP in determining cell fate in retinitis pigmentosa, and point to a promising new neuroprotective strategy for this currently incurable disease.
results suggest that VCP plays a mechanistic role in releasing WRNp from the nucleolus
rescue experiments with a lethal mfap1 (show MFAP1 Antibodies) mutant show that the VCP binding region is not essential for Mfap1 (show MFAP1 Antibodies) function, but may act to increase its stability or activity
Clu (show CLU Antibodies) is upstream of and binds to VCP in vivo and promotes VCP-dependent Marf (show MFN2 Antibodies) degradation in vitro Marf (show MFN2 Antibodies) accumulates in whole muscle lysates of clu (show CLU Antibodies)-deficient flies and is destabilized upon Clu (show CLU Antibodies) overexpression. Thus, Clu (show CLU Antibodies) is essential for mitochondrial homeostasis and functions in concert with Parkin (show PARK2 Antibodies) and VCP for Marf (show MFN2 Antibodies) degradation to promote damaged mitochondrial clearance.
results have revealed SUMOylation as a molecular signaling switch to regulate the distribution and functions of VCP during stress response, and suggest that deficiency in VCP SUMOylation caused by pathogenic mutations will render cells vulnerable to stress insults.
The authors propose that VCP sustains sarcoplasmic proteostasis, in part, by controlling the integrity of a dynamic tubular lysosomal network.
Ter94/VCP appears to be an evolutionarily conserved component that regulates BMP (show TGFb Antibodies)-Smad1 (show SMAD1 Antibodies)/5/8 signaling.
Data identifies that ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration (show CLN8 Antibodies) induced by knockdown of Caz, Drosophila FUS (show FUS Antibodies)
Valosin-Containing Protein has an essential role in dendrite pruning through regulating mRNA metabolism
VCP was validated as an atlastin (show ATL1 Antibodies)-interacting protein.
Ter94 ATPase (show DNAH8 Antibodies) and K11-linked ubiquitination in Ci contribute to the selectivity by proteasomes for partial degradation.
VCP binds to DIAP1 in a ubiquitin- and BIR domain-dependent manner and facilitates its degradation, therefore, establishing a new link between ubiquitin, dendrite pruning and the apoptosis machinery.
The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.
15S Mg(2+)-ATPase p97 subunit
, TER ATPase
, transitional endoplasmic reticulum ATPase
, valosin-containing protein
, yeast Cdc48p homolog
, p97 ATPase
, AAA ATPase p97
, Inv protein
, homolog of yeast cdc48
, valosin containing protein
, CG2331 gene product from transcript CG2331-RA
, TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE TER94
, Valosin-Containing protein
, Valosin-containing protein homolog
, complementation group I
, transitional endoplasmic reticulum 94
, Fanconi anemia group G protein
, Fanconi anemia, complementation group G