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anti-Human NR4A1 Antibodies:
anti-Mouse (Murine) NR4A1 Antibodies:
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Human Polyclonal NR4A1 Primary Antibody for ChIP, ICC - ABIN252681
Nakai, Kartha, Sakurai, Toback, DeGroot: A human early response gene homologous to murine nur77 and rat NGFI-B, and related to the nuclear receptor superfamily. in Molecular endocrinology (Baltimore, Md.) 1991
Show all 12 Pubmed References
Mouse (Murine) Monoclonal NR4A1 Primary Antibody for WB - ABIN967395
Davis, Hazel, Chen, Blenis, Lau: Functional domains and phosphorylation of the orphan receptor Nur77. in Molecular endocrinology (Baltimore, Md.) 1993
Show all 5 Pubmed References
Cow (Bovine) Polyclonal NR4A1 Primary Antibody for IHC, WB - ABIN2782269
Smith, Luk, Newton, Roberts, Sturm, Muscat: Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells. in The Journal of biological chemistry 2008
Show all 2 Pubmed References
Cow (Bovine) Polyclonal NR4A1 Primary Antibody for IHC, WB - ABIN2777511
Lu, Suzuki, Yoshikawa, Murakami, Miki, Moriya, Bassett, Rainey, Hayashi, Sasano: Nur-related factor 1 and nerve growth factor-induced clone B in human adrenal cortex and its disorders. in The Journal of clinical endocrinology and metabolism 2004
Show all 2 Pubmed References
Human Polyclonal NR4A1 Primary Antibody for ELISA, IHC (p) - ABIN188670
Kiss, Oskolás, Tóth, Bouillet, Tóth, Fülöp, Scholtz, Ledent, Fésüs, Szondy: Adenosine A2A receptor-mediated cell death of mouse thymocytes involves adenylate cyclase and Bim and is negatively regulated by Nur77. in European journal of immunology 2006
we show here that the BCR (show BCR Antibodies)/BTK (show BTK Antibodies) target gene NR4A1 is a potential oncogene (show RAB1A Antibodies) in mantle cell lymphoma
this study confirmed that NR4A1 sensitizes gastric cancer cells to TNFalpha (show TNF Antibodies)-induced apoptosis through the inhibition of JNK (show MAPK8 Antibodies)/Parkin (show PARK2 Antibodies)-dependent mitophagy.
Inhibition of NR4A1 in stromal cells increased the TGF-beta1 (show TGFB1 Antibodies)-dependent elevated expression of fibrotic markers, and loss of NR4A1 stimulated fibrogenesis in mice with endometriosis.
NR4A1 knockdown partly decreased surface NR2B (show GRIN2B Antibodies) by promoting NR2B (show GRIN2B Antibodies) internalization.
Data show that SUMOylation is critical in controlling NR4A1 function in inflammatory cytokine signaling and controlling macrophage cell death.
our findings suggest that hypoxia-induced down-regulation of TR3 might play an important role for hypoxia-induced apoptosis resistance in NSCLC.
Nur77 suppresses CD4 (show CD4 Antibodies)(+) T cell proliferation and uncover a suppressive role for Irf4 (show IRF4 Antibodies) in TH2 polarization; halving Irf4 (show IRF4 Antibodies) gene-dosage leads to increases in GATA3 (show GATA3 Antibodies)(+) and IL-4 (show IL4 Antibodies)(+) cells.
our data demonstrated that NR4A1 protein physically associates with the WT1 (show WT1 Antibodies) promoter, and enhanced WT1 (show WT1 Antibodies) promoter transactivation and knockdown of WT1 (show WT1 Antibodies) in MIN6 cells induced apoptosis. These findings suggest that NR4A1 protects pancreatic beta-cells against H2O2 mediated apoptosis by up-regulating WT1 (show WT1 Antibodies) expression.
NR4A modulates the decidualization of hESCs by upregulating prolactin (PRL (show PRL Antibodies)) and insulin-like growth factor binding protein-1 (IGFBP-1 (show IGFBPI Antibodies)) expression and transformation in vitro.
DNMT1 (show DNMT1 Antibodies) causes NR4A1 DNA hypermethylation and blocks insulin (show INS Antibodies) signaling in an Chinese patients with type 2 diabetes
Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.
NR4A1 knockdown interrupted the Mff (show MFF Antibodies)-related mitochondrial fission and recused Parkin (show PARK2 Antibodies)-mediated mitophagy, reducing the hyperglycemia-mediated mitochondrial damage and thus improving renal function.
we found that either knockdown of Nr4a1 or 3, 3'- Diindolylmethane (DIM), an Nr4a1 antagonist, were able to rescue the effects of SNRPN (show SNRPN Antibodies) knockdown on neurite outgrowth of embryonic cortical neurons, providing the potential therapeutic methods for SNRPN (show SNRPN Antibodies) deletion disorders. We thus concluded that maintaining the proper level of SNRPN (show SNRPN Antibodies) is critical in cortical neurodevelopment.
new insights into the understanding the mechanisms of the effects of Nur77 on LPS (show TLR4 Antibodies)-activated microglia
These results suggest that berberine-induced activation of AMPK (show PRKAA1 Antibodies) may contribute to hepatic FGF21 (show FGF21 Antibodies) expression via NUR77.
we found that KLF6 (show KLF6 Antibodies) transcriptionally cooperates with NUR77 and SF1 (show SF1 Antibodies)
Ca(2 (show CA2 Antibodies)+) signaling pathway increases Nr4a1 expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (show MEF2C Antibodies), AP1 (show JUN Antibodies), and CREB (show CREB1 Antibodies) transcription factors thus demonstrating an important interplay between the Ca(2 (show CA2 Antibodies)+) and cAMP pathways in regulating Nr4a1 expression.
additional loss of Nur77 in the absence of Bim (show BCL2L11 Antibodies) led to diabetes induction, suggesting that Nur77 promotes tolerance in this context. Together, these data reveal novel nondeletional roles for Nur77 that differ between T cell subsets and have implications for self-tolerance.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, TR3 orphan receptor
, early response protein NAK1
, growth factor-inducible nuclear protein N10
, hormone receptor
, nerve growth factor IB nuclear receptor variant 1
, nuclear hormone receptor NUR/77
, nuclear receptor subfamily 4 group A member 1
, orphan nuclear receptor HMR
, orphan nuclear receptor TR3
, steroid receptor TR3
, testicular receptor 3
, orphan nuclear receptor NGFI-B
, nuclear protein N10
, Orphan nuclear receptor HMR
, immediate early gene transcription factor NGFI-B
, nerve growth factor induced protein I-B
, nerve growth factor-induced protein I-B