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study proposes that Trb3 governs left-right (LR) axis patterning as a component of TGF-signaling in embryonic development
TRIB3, a single-domain protein with impaired kinase catalytic activity, has been described to perform a complex of roles, many of which are likely to be cell type-specific. (Review)
High TRB3 expression is associated with basal-like breast cancer.
TRIB3 promotes acute promyelocytic leukemia (show PML Proteins) progression through stabilization of the oncoprotein PML (show PML Proteins)-RARalpha (show RARA Proteins) and inhibition of p53 (show TP53 Proteins)-mediated senescence.
Downregulation of TRIB3 is associated with lung cancer.
This study aims to investigate whether the Tribbles 3 Q84R polymorphism has profound effects on serum semaphorin 3E (show SEMA3E Proteins) and what effect semaphorin 3E (show SEMA3E Proteins) exerts on carotid atherosclerosis.
overexpression of TRIB3 is associated with tumor angiogenesis and a poor prognosis in patients with gastric cancer (GC) . Our findings indicate that TRIB3 is a promising target for antiangiogenic therapy in GC.
Our findings suggest that good glucose and blood pressure control exhibited greater benefits on vascular outcomes in patients with TRIB3 (rs2295490) G allele.
In this exploratory analysis, IRS1 (show IRS1 Proteins), ENNP1 and TRIB3, known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (show INS Proteins) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.
TRIB3 acts as a crucial 'stress adjusting switch' that links homeostasis, metabolic disease and cancer; and is being actively investigated as a disease biomarker and therapeutic target
TRB3 is upregulated in macrophages upon treatment with ox-LDL. TRB3 promotes lipid accumulation and suppresses cytokine expression, suggesting inflammation and foam cell formation can be reciprocally regulated.
TRB3 regulates protein synthesis and breakdown via the Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins)/FoxO (show FOXO3 Proteins) pathways in skeletal muscle.
Chac1 (show CHAC1 Proteins) expression is detrimental to arsenite-treated cell survival and TRIB3 is critical for restraining the pro-death potential of Chac1 (show CHAC1 Proteins) during arsenite stress.
Under physiological conditions, muscle TRIB3 also influences energy expenditure and substrate metabolism, indicating that the decrease and increase in muscle TRIB3 under fasting and nutrient excess, respectively, are critical for metabolic homeostasis.
In a knockout mouse model, Trib3 disruption modestly increased steady-state erythrocyte numbers and decreased mean corpuscular volume.
Palmitate increased TRB3 expression, activated IRE1alpha (show ERN1 Proteins) signaling, and reduced the insulin (show INS Proteins)-dependent Akt (show AKT1 Proteins) phosphorylation. Knocking down TRB3 or IRE1alpha (show ERN1 Proteins) did not prevent the inhibitory effect of palmitate on Akt (show AKT1 Proteins) phosphorylation. Results support the idea that ER stress is not responsible for lipid-induced IR in C2C12 myotubes.
These data demonstrate that TRB3 inhibits insulin (show INS Proteins) signaling in BAT (show BAAT Proteins), resulting in impaired differentiation and function.
TRB3 is a novel profibrotic mediator in SSc (show CYP11A1 Proteins). TGF-beta (show TGFB1 Proteins) induces TRB3, which in turn activates canonical TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling and stimulates the release of collagen, creating a positive feedback loop that may contribute to aberrant TGF-beta (show TGFB1 Proteins) signalling in SSc (show CYP11A1 Proteins).
study presents the finding that activation of the NF-kappaB (show NFKB1 Proteins) pathway by Porphyromonas endodontalis LPS (show TLR4 Proteins) is important for Wnt5a (show WNT5A Proteins) expression in osteoblasts, and that TRIB3 may modulate the sustained expression of Wnt5a (show WNT5A Proteins) in osteoblasts stimulated by P. endodontalis
TRIB1 (show TRIB1 Proteins) and TRIB3 are more strongly expressed than TRIB2 (show TRIB2 Proteins) in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.
This work aimed to study the porcine tribbles homolog 3 (TRIB3) gene and to evaluate its association with meat quality and carcass traits in pigs.
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1.
tribbles homolog 3
, tribbles homolog 3 (Drosophila)
, tribbles homolog 3-like
, neuronal cell death inducible putative kinase
, neuronal cell death-inducible putative kinase
, p65-interacting inhibitor of NF-kappa-B
, p65-interacting inhibitor of NF-kappaB
, induced in fatty liver dystrophy 2
, Neuronal cell death Inducible Putative Kinase
, tribbles 3