FCGR3A Proteins
(Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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31 results
FCGR3A
Origin: Mouse
Host: Escherichia coli (E. coli)
Recombinant
> 90 %
SDS, WB, Imm, PC
FCGR3A
Origin: Rat
Host: Escherichia coli (E. coli)
Recombinant
> 95 %
SDS, WB, Imm, PC
FCGR3A
Origin: Human
Host: Baculovirus infected Insect Cells
Recombinant
> 95% by SDS-PAGE
SDS, AcA
Active
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95% by SDS-PAGE
SDS, AcA
Active
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
1 image
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
1 image
FCGR3A
Origin: Human
Host: Human Cells
Recombinant
Greater than 95 % as determined by reducing SDS-PAGE.
SDS, WB, ELISA, MS
Latest Publications for our FCGR3A Proteins
: "FcγR Binding and ADCC Activity of Human IgG Allotypes." in: Frontiers in immunology, Vol. 11, pp. 740, (2020) (PubMed).: "Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies." in: mAbs, Vol. 11, Issue 5, pp. 826-836, (2020) (PubMed).
: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
: "Identification of anti-CD16a single domain antibodies and their application in bispecific antibodies." in: Cancer biology & therapy, pp. 1-9, (2019) (PubMed).
: "Structural and functional characterization of MBS301, an afucosylated bispecific anti-HER2 antibody." in: mAbs, Vol. 10, Issue 6, pp. 864-875, (2019) (PubMed).
: "Charge variant analysis of proposed biosimilar to Trastuzumab." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 46, pp. 46-56, (2017) (PubMed).
: "Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactions." in: Journal of proteome research, Vol. 13, Issue 12, pp. 5471-85, (2014) (PubMed).
: "Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9986-93, (2009) (PubMed).
Aliases for FCGR3A Proteins
Fc fragment of IgG receptor IIIa (FCGR3A) ProteinsFc fragment of IgG receptor IIIa (Fcgr3a) Proteins
CD16 Proteins
CD16A Proteins
FCG3 Proteins
FCGR3 Proteins
Fcgr4 Proteins
FCGRIII Proteins
FCR-10 Proteins
FCRIII Proteins
FCRIIIA Proteins
IGFR3 Proteins
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