FCGR3A Proteins
(Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A))
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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35 results :
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95 % by SEC-HPLC
SDS, SEC-HPLC, SPR
FCGR3A
Origin: Human
Host: Wheat germ
Recombinant
WB, ELISA, AP, AA
1 image
1 reference
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Active
2 references
FCGR3A
Origin: Cynomolgus
Host: Human Cells
Recombinant
>95 % as determined by reducing SDS-PAGE.
1 image
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
1 image
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
> 97 % as determined by reducing SDS-PAGE.
Active
1 image
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
> 90 % as determined by reducing SDS-PAGE.
Active
1 image
FCGR3A
Origin: Rat
Host: HEK-293 Cells
Recombinant
> 97 % as determined by SDS-PAGE
Active
1 image
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
Active
1 image
FCGR3A
Origin: Mouse
Host: HEK-293 Cells
Recombinant
>95 % as determined by reduced SDS-PAGE.
Active
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
>95 % as determined by SDS-PAGE.
Active
FCGR3A
Origin: Cynomolgus
Host: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
FCGR3A
Origin: Human
Host: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
FCGR3A
Origin: Human
Host: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
FCGR3A
Origin: Human
Host: HEK-293 Cells
Recombinant
> 95 % by SDS-PAGE.
Active
FCGR3A
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
SDS, WB, ELISA
FCGR3A
Origin: Human
Host: Escherichia coli (E. coli)
Recombinant
SDS, WB, ELISA
Latest Publications for our FCGR3A Proteins
: "FcγR Binding and ADCC Activity of Human IgG Allotypes." in: Frontiers in immunology, Vol. 11, pp. 740, (2020) (PubMed).: "Effects of terminal galactose residues in mannose α1-6 arm of Fc-glycan on the effector functions of therapeutic monoclonal antibodies." in: mAbs, Vol. 11, Issue 5, pp. 826-836, (2020) (PubMed).
: "Control of therapeutic IgG antibodies galactosylation during cultivation process and its impact on IgG1/FcγR interaction and ADCC activity." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 58, pp. 16-21, (2019) (PubMed).
: "Identification of anti-CD16a single domain antibodies and their application in bispecific antibodies." in: Cancer biology & therapy, pp. 1-9, (2019) (PubMed).
: "Structural and functional characterization of MBS301, an afucosylated bispecific anti-HER2 antibody." in: mAbs, Vol. 10, Issue 6, pp. 864-875, (2019) (PubMed).
: "Charge variant analysis of proposed biosimilar to Trastuzumab." in: Biologicals : journal of the International Association of Biological Standardization, Vol. 46, pp. 46-56, (2017) (PubMed).
: "Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactions." in: Journal of proteome research, Vol. 13, Issue 12, pp. 5471-85, (2014) (PubMed).
: "Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9986-93, (2009) (PubMed).
Aliases for FCGR3A Proteins
Fc fragment of IgG receptor IIIa (FCGR3A) ProteinsFc fragment of IgG receptor IIIa (Fcgr3a) Proteins
CD16 Proteins
CD16A Proteins
FCG3 Proteins
FCGR3 Proteins
Fcgr4 Proteins
FCGRIII Proteins
FCR-10 Proteins
FCRIII Proteins
FCRIIIA Proteins
IGFR3 Proteins
Did you look for something else?
- FCGR2B Proteins
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- FCGR1A Proteins
- FCGR1 Proteins
- FCGBP Proteins
- FCF1 Proteins
- FCER2 Proteins
- FCAR Proteins
- FCAMR Proteins
- Fc Receptor, IgG, Low Affinity IV Proteins
- Fc gamma RII Proteins
- Fc epsilon RI/FCER1A Proteins
- FBXW9 Proteins
- FBXW8 Proteins
- FBXW7 Proteins
- FBXW5 Proteins
- FBXW4 Proteins
- FBXW2 Proteins
- FBXW11 Proteins
- FBXO9 Proteins
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