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anti-Rat (Rattus) Glutaminase Antibodies:
anti-Human Glutaminase Antibodies:
anti-Mouse (Murine) Glutaminase Antibodies:
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Human Monoclonal Glutaminase Primary Antibody for IF, ELISA - ABIN561056
Unterluggauer, Mazurek, Lener, Hütter, Eigenbrodt, Zwerschke, Jansen-Dürr: Premature senescence of human endothelial cells induced by inhibition of glutaminase. in Biogerontology 2008
Show all 4 Pubmed References
Human Polyclonal Glutaminase Primary Antibody for ICC, IF - ABIN4314688
Tanaka, Sasayama, Irino, Takata, Nagashima, Satoh, Kyotani, Mizowaki, Imahori, Ejima, Masui, Gini, Yang, Hosoda, Sasaki, Mischel, Kohmura: Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment. in The Journal of clinical investigation 2015
Human Polyclonal Glutaminase Primary Antibody for ELISA, WB - ABIN561055
Shajahan-Haq, Cook, Schwartz-Roberts, Eltayeb, Demas, Warri, Facey, Hilakivi-Clarke, Clarke: MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer. in Molecular cancer 2014
Human Polyclonal Glutaminase Primary Antibody for FACS, ICC - ABIN4314689
Li, Han, Li, Kan, Fan, Li, Ji, Zhao, Zhang, Grigalavicius, Berge, Goscinski, Nesland, Suo: Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells. in Oncotarget 1970
Dog (Canine) Polyclonal Glutaminase Primary Antibody for WB - ABIN2786054
Sahai: Glutaminase in human platelets. in Clinica chimica acta; international journal of clinical chemistry 1983
miR (show MLXIP Antibodies)-137 was decreased in melanoma tissue, and the low miR (show MLXIP Antibodies)-137 levels and high glutaminase expression are independent risk factors in melanoma. miR (show MLXIP Antibodies)-137 suppressed the proliferation and glutamine (show GFPT1 Antibodies) catabolism of melanoma cells.
Gls is a novel ERRalpha (show ESRRA Antibodies) target gene.
ZIC5 (show ZIC5 Antibodies) positively regulated the proliferation, migration (Fig. 2), and survival (Fig. 5) of PCa (show FLVCR1 Antibodies) and CRC (show CALR Antibodies) cells
the crystal structure of full-length KGA and present a small-angle X-ray scattering model for full-length GLS2 (show GLS2 Antibodies). These structures explain these proteins' compromised ability to assemble into catalytically active supra-tetrameric filaments, as previously shown for GAC.
GLS1 inhibition using BPTES reduced metabolic intermediates including thymidine and carbamoyl phosphate. Reduction of thymidine and carbamoyl-phosphate synthesis by BPTES treatment exacerbated pyrimidine supply by combination with 5-FU, which induced cell death synergistically in NSCLC
studies show that the formation of large GAC oligomers is not a pre-requisite for full enzymatic activity. They also offer a mechanism by which the binding of activators like inorganic phosphate enables the activation loop to communicate with the active site to ensure maximal rates of catalysis, and promotes the opening of the lid to achieve optimal product release.
Glutaminase expression in tumor cells was significantly associated with a low level of tumor-infiltrating lymphocytesand poor disease-free survival in triple-negative breast cancers presenting with lymph node metastasis and high levels of tumor-infiltrating lymphocytes.
Study reports that GLS1 is a direct target of miR (show MLXIP Antibodies)-23a in retinal pigment epithelium cells (RPE (show RPE Antibodies)) providing evidence for a role in maintaining RPE (show RPE Antibodies) cell function.
The relative expression of microRNA-153 and glutaminase in glioblastoma versus matched non-tumor tissues showed a reverse correlation, further indicating that microRNA-153 may negatively regulate glutaminase in vivo.
High GLS1 expression is associated with epithelial-mesenchymal transition in cancer.
Our results suggested that glutamine (show GFPT1 Antibodies) metabolism is involved in the pathogenesis of rheumatoid arthritis and that GLS1 plays an important role in regulating rheumatoid arthritis fibroblast-like synoviocyte proliferation
Gls2 (show GLS2 Antibodies) expression is regulated by the dietary protein/carbohydrate ratio. This effect was not observed in Ppara (show PPARA Antibodies)-null mice.
Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators.
findings suggest that glutaminase Heterozygote mice have a pro-cognitive profile in the trace fear conditioning paradigm, and this phenotype involves activation of both hippocampus and Anterior Cingulate Cortex.
studies demonstrate that GLS is required for tumorigenesis and support small molecule and genetic inhibition of GLS as potential approaches for targeting the tumor cell-autonomous dependence on GLS for cancer therapy.
The Phosphate-Activated Glutaminase (show GLS2 Antibodies)(PAG (show PRDX1 Antibodies)) is mainly active in mouse kidney, brain and liver, and shows different kinetics depending on which type of PAG (show PRDX1 Antibodies) is expressed.
The network identified in glutaminase deficient fetal mouse brain involves (a) cellular assembly and organization and (b) cell signaling and cell cycle, suggesting that Gls is crucial for neuronal maturation.
kidney-type glutaminase (KGA) as a novel partner of Bmcc1s
The up-regulation of neuronal glutaminase was demonstrated in situ in a murine model of HIV-1 encephalitis.
The memory deficits observed in nemy are because of reduced function of CytB561 (show CYB561 Antibodies) in specific brain regions that are involved in learning and memory.
This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants.
, L-glutamine amidohydrolase
, glutaminase kidney isoform, mitochondrial
, glutaminase C
, phosphate-activated glutaminase
, glutaminase, phosphate-activated
, glutaminase liver isoform, mitochondrial
, liver mitochondrial glutaminase