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anti-Human Tryptophan Hydroxylase 1 Antibodies:
anti-Mouse (Murine) Tryptophan Hydroxylase 1 Antibodies:
anti-Rat (Rattus) Tryptophan Hydroxylase 1 Antibodies:
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Human Polyclonal Tryptophan Hydroxylase 1 Primary Antibody for IHC (fro), IHC - ABIN152521
Haycock, Kumer, Lewis, Vrana, Stockmeier: A monoclonal antibody to tryptophan hydroxylase: applications and identification of the epitope. in Journal of neuroscience methods 2002
Show all 2 Pubmed References
Human Polyclonal Tryptophan Hydroxylase 1 Primary Antibody for IHC (fro), WB - ABIN2476982
Lowry, Rodda, Lightman, Ingram et al.: Corticotropin-releasing factor increases in vitro firing rates of serotonergic neurons in the rat dorsal raphe nucleus: evidence for activation of a topographically organized mesolimbocortical ... in The Journal of neuroscience : the official journal of the Society for Neuroscience 2000
These findings indicate that TPH1, TPH2 (show TDO2 Antibodies), and SLC6A4 (show SLC6A4 Antibodies) variants moderate the subjective effects of cocaine in non-treatment-seeking cocaine-dependent participants.
TPH-1 is overexpressed in remodeled pulmonary arteries of patients with idiopathic Pulmonary Arterial Hypertension .
Elderly Croatian Suicide completers, but not younger Suicide completers (below 65 years old), had higher frequencies of the CC genotype of polymorphisms localized in intron 7 of Typtophane Hydroxylase (TPH1) gene.
These results suggested that silencing of androgen/androgen receptor (show AR Antibodies) signaling may cause initiation and progression of seminomas through increase in TPH1 gene expression level.
The catalytic domain of TPH1 shares a sequence identity of 81% with TPH2 (show TDO2 Antibodies). Despite the high sequence identity, differences in the kinetic parameters of the isoforms have been identified; i.e., only TPH1 displays substrate tryptophan inhibition.
results confirm the role of TPH1, TPH2 (show TDO2 Antibodies), 5HT2A, CRHR1 (show CRHR1 Antibodies) and ACP1 (show ACP1 Antibodies) variants in the risk of suicidal behavior.
Tryptophan Hydroxylase 1 Variant rs1800532 is associated with Suicide Attempt in Serbian Psychiatric Patients.
This study demonstrates that both TPH1 and TPH2 (show TDO2 Antibodies) are expressed in human and mouse placenta throughout pregnancy and helps to better understand the placental serotonin system, which is crucial for healthy pregnancy and fetal development.
Genetic association studies have revealed contradictory results about the effect of the TPH1 A218C (rs1800532) polymorphism on suicidal behavior in different populations. Investigated A218C polymorphism in 109 suicide attempters and 98 healthy controls. Our results provide evidence that A allele of TPH1 A218C polymorphism may be associated with suicidal behavior in Turkish population
The regulatory domain of isoform 1 of tryptophan hydroxylase was expressed and purified; mutagenesis of Cys64 was required to prevent formation of disulfide-linked dimers.
The authors show that the interactions between daf-7 and tph-1 regulate redundancy and synergy among neurons in food encoding through coordinated control of circuit-level signal and noise properties.
A gene-expression-based neural code for food abundance that modulates lifespan includes daf-7 that primarily regulates gene-expression variability, while tph-1 primarily regulates the dynamic range of gene-expression responses.
tph-1 mutants failed to exhibit ethanol interference with gustatory plasticity in Caenorhabditis elegans
Data suggest that central melanocortin-4 receptor (MC4-R (show MC4R Antibodies)) and tryptophan hydroxylase (TPH) are involved in the efferent neuronal control of the kidneys.
Prolactin (show PRL Antibodies)-induced Tph1 expression.
Tph1-deficient mice fed a high-fat diet (HFD) are protected from obesity, insulin (show INS Antibodies) resistance and nonalcoholic fatty liver disease (NAFLD (show TSC2 Antibodies)) while exhibiting greater energy expenditure by brown adipose tissue.
Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities.
ZBP-89 (show ZNF148 Antibodies) directly binds to the Tph1 promoter, which is required for its basal and butyrate-inducible expression.
TPH1 deficiency or inhibition reduces allergic airway inflammation. Platelet-derived 5-HT (show DDC Antibodies) is pivotal in AAI and lack of 5-HT (show DDC Antibodies) leads to impaired Th2 priming capacity of bone marrow dendritic cells.
Data indicate that tryptophan hydroxylase (Tph)1-deficient mice, lacking non-neuronal serotonin, showed mild leukocytosis.
Data show that Tph-1 (tryptophan hydroxylase-1) is a potent regulator of immunity.
Parallel to Tph1 mRNA and protein induction, islet serotonin content increased to a peak level that was 200-fold higher than basal. Interestingly, only a subpopulation of the beta cells was serotonin-positive in vitro and in vivo.
nonneuronal tph1 gene has a role in cardiac function with peripheral serotonin
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.
, indoleacetic acid-5-hydroxylase
, tryptophan 5-hydroxylase 1
, tryptophan 5-monooxygenase 1
, tryptophan hydroxylase (tryptophan 5-monooxygenase)
, tryptophan hydroxylase (tryptophan 5-monooxygenase
, tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)
, tryptophan 5-hydroxylase 2
, TryPtophan Hydroxylase family member (tph-1)
, tryptophan 5-hydroxylase
, tryptophan 5-monooxygenase
, secretion regulating guanine nucleotide exchange factor
, tryptophan hydroxylase 1
, tryptophan 5-hydroxylase 1-like