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There were no significant differences in the prevalence of GNAQ (show GNAQ Proteins) and GNA11 mutations between patients with or without metastatic disease
a novel germline gain-of-function Galpha11 mutation, Val340Met, causing Autosomal Dominant Hypocalcemia Type 2 demonstrates the importance of the Galpha11 C-terminal region for G-protein function and CaSR (show CASR Proteins) signal transduction.
studies have identified a third Galpha11 mutation (Thr54Met) causing Familial Hypocalciuric Hypercalcemia Type 2 and reveal a critical role for the Galpha11 interdomain interface in CaSR (show CASR Proteins) signaling and Ca(2 (show CA2 Proteins)+) o homeostasis.
Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 (show SOX10 Proteins) expression and presence of the BRAF (show BRAF Proteins) V600E mutation.
Mutations in GNAQ (show GNAQ Proteins) and GNA11 genes in Greek uveal melanoma population present frequencies that qualify them as potential targets for customized therapy.
Sporadic melanotic schwannoma with overlapping features of melanocytoma bearing a GNA11 mutation in an adolescent girl.
we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ (show GNAQ Proteins), GNA11, and EIF1AX (show EIF1AX Proteins) mutations.
GNAQ and GNA11 mutations occur frequently in mucosal melanoma and may be a prognostic factor for MM. Our data implicate that GNAQ/11 may be potential targets for targeted therapy of mucosal melanoma.
CGRP (show S100A12 Proteins) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas (show GNAS Proteins), Galphai, and Galphaq (show GNAQ Proteins)/11 pathways.
The identified GNA11 mutation results in biochemical abnormalities typical for autosomal dominant hypocalcemia. Additional features, including short stature and early intracranial calcifications, cosegregated with the mutation.
G protein-coupled receptor Kinase 2 reacts with this protein's signaling homology domain for binding G protein subunits
The phylogenetic trees reveal that porcine Gna11, is evolutionarily close to the human homolog.
Galpha11 is inhibitory to osteoanabolic actions of both parathyroid hormone (show PTH Proteins) and exercise
results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta (show TGFB1 Proteins) activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 (show IL33 Proteins) synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq (show GNAQ Proteins)/11-dependent fashion.
claudin-3 (show CLDN3 Proteins) and claudin-5 (show CLDN5 Proteins) expression is increased by DHEAS (show SULT2A1 Proteins) and tight junction formation is stimulated via a Gnalpha11-coupled receptor in Sertoli cells
ZIP9/Gna11 interactions mediate the non-classical testosterone signaling cascade in spermatogenic GC-2 cells.
the conditional deletion of Galphaq (show GNAQ Proteins)/11 from granulosa/luteal cells prevents the progesterone withdrawal that occurs at the end of pregnancy and impairs parturition.
Loss of gq/11 genes does not abolish melanopsin (show OPN4 Proteins) phototransduction.
Mediated by lysophosphatidylinositol, Galpha(q (show GNAQ Proteins)/11) is activated in sensory neurons.
Dehydroepiandrosterone sulfate (DHEAS (show SULT2A1 Proteins))-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor (show GPR34 Proteins), since silencing of Gnalpha11 leads to the abolition of the DHEAS (show SULT2A1 Proteins)-induced stimulation of Erk1/2, ATF-1 (show AFT1 Proteins), and CREB (show CREB1 Proteins).
Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase (show MAPK1 Proteins) cascade via the Galpha(q (show GNAQ Proteins)/11)--p63RhoGEF--RhoA (show RHOA Proteins) axis.
may be involved in mediating second messenger signals from the endothelin receptor in adipocytes
Guanine nucleotide-binding protein alpha-11 subunit
, phospholipase C-activating G-protein
, G-protein subunit alpha-11
, g alpha-11
, guanine nucleotide-binding protein G(y) subunit alpha
, guanine nucleotide-binding protein subunit alpha-11
, guanine nucleotide-binding protein, Gq class, GNA11
, G-protein subunit GL2 alpha
, G alpha-11
, guanine nucleotide binding protein alpha 11
, guanine nucleotide regulatory protein G alpha 11
, guanine nucleotide-binding protein alpha 11 subunit