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anti-Human Aggrecan Antibodies:
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Cow (Bovine) Polyclonal Aggrecan Primary Antibody for ICC, FACS - ABIN261460
Huang, Lai, Hung, Wu, Liu, Ho: Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes. in Rheumatology (Oxford, England) 2011
Show all 9 Pubmed References
Chicken Monoclonal Aggrecan Primary Antibody for ICC, IHC (fro) - ABIN265914
Li, Gan, Wang, Xu, Song, Zhang, Li, Zhou: Biological Responses of the Immature Annulus Fibrosus to Dynamic Compression in a Disc Perfusion Culture. in Cells, tissues, organs 2016
Show all 7 Pubmed References
Cat (Feline) Monoclonal Aggrecan Primary Antibody for ELISA, ICC - ABIN153389
Little, Hughes, Curtis, Janusz, Bohne, Wang-Weigand, Taiwo, Mitchell, Otterness, Flannery, Caterson: Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. in Matrix biology : journal of the International Society for Matrix Biology 2002
Show all 6 Pubmed References
Human Polyclonal Aggrecan Primary Antibody for IF (p), IHC (p) - ABIN673599
Lei, Li, Li, Gao, Chen, Jin: Mesenchymal stem cell characteristics of dental pulp and periodontal ligament stem cells after in vivo transplantation. in Biomaterials 2014
Show all 5 Pubmed References
Cow (Bovine) Monoclonal Aggrecan Primary Antibody for IHC (fro), IHC (p) - ABIN258953
Krouwels, Melchels, van Rijen, Ten Brink, Dhert, Cumhur Öner, Tryfonidou, Creemers: Focal adhesion signaling affects regeneration by human nucleus pulposus cells in collagen- but not carbohydrate-based hydrogels. in Acta biomaterialia 2017
Show all 2 Pubmed References
Rat (Rattus) Polyclonal Aggrecan Primary Antibody for ICC, IHC - ABIN1857938
Dai, Chu, Tian, Song, Wang, Zhang, Zhang: Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture in meniscectomized guinea pigs. in Osteoarthritis and cartilage 2016
Show all 2 Pubmed References
Cow (Bovine) Monoclonal Aggrecan Primary Antibody for IHC (fro), IHC (p) - ABIN2477296
Wang, Smith, Lau: Transcriptional regulation of the liver beta-galactoside alpha 2,6-sialyltransferase by glucocorticoids. in The Journal of biological chemistry 1990
Show all 2 Pubmed References
Cow (Bovine) Monoclonal Aggrecan Primary Antibody for ELISA, ICC - ABIN6244839
Bouhenni, Hart, Al-Jastaneiah, AlKatan, Edward: Immunohistochemical expression and distribution of proteoglycans and collagens in sclerocornea. in International ophthalmology 2013
Cow (Bovine) Monoclonal Aggrecan Primary Antibody for EIA, IHC (fro) - ABIN1450192
Anders, Mollenhauer, Beberhold, Kinne, Venbrocks: Gelatin-based haemostyptic Spongostan as a possible three-dimensional scaffold for a chondrocyte matrix?: an experimental study with bovine chondrocytes. in The Journal of bone and joint surgery. British volume 2009
Show all 3 Pubmed References
Reciprocal translocation t(10;15)(q22.3;q26.1) interrupting ACAN gene is associated with short stature.
genetic association studies in pediatric population in Japan: Data suggest that mutations in ACAN (aggrecan), FGFR3 (fibroblast growth factor receptor-3 (show FGFR3 Antibodies)), or GHRHR (growth- hormone-releasing-hormone receptor (show GHRHR Antibodies)) are associated with idiopathic short stature in the population studied.
In bicuspid aortic valve disease, there was a significant reduction of aggrecan expression in bicuspid aortic valve.
Overexpression of miR (show MLXIP Antibodies)-3150a-3p decreased ACAN expression in nucleus pulposus cells, whereas inhibition of miR (show MLXIP Antibodies)-3150a-3p increased ACAN expression. In addition, ACAN expression was negatively correlated with intervertebral disc degeneration (IDD (show COL9A3 Antibodies)) grade. The reduction of ACAN expression induced by the upregulation of miR (show MLXIP Antibodies)-3150a-3p might participate in the development of IDD (show COL9A3 Antibodies).
Our study demonstrated that altered levels of ADAMTS-1 (show ADAMTS1 Antibodies) and aggrecan may have a partial role in the etiopathogenesis of Polycystic ovary syndrome (PCOS), and ADAMTS-1 (show ADAMTS1 Antibodies) could be a predictive marker for implantation success in PCOS patients.
ACAN mutation is a relative common cause of familial severe short stature
Chondrogenic potential was higher and Wnt/beta-catenin signaling was more potently activated by a GSK-3beta inhibitor in the posterior than in the anterior part of the human infant sclera.
single nucleotide variants of ACAN and their haplotypes are associated with the severity of lumbar disc herniation.
Four of 29 small for gestational age children with advanced bone age had an ACAN gene mutation (13.8%). Mutations were related to additional characteristics: midface hypoplasia, joint problems, and broad great toes.
SNVs of candidate genes in ACAN metabolic pathway are associated with severity of Lumbar disc degeneration and Modic changes in patients with chronic mechanical low back pain.
Kartogenin effectively increased the expression of Col (show HDAC1 Antibodies) II and aggrecan in hNPCs and slowed the degeneration of intervertebral discs stimulated by IL-1b (show IL1B Antibodies) and TNF-a (show TNF Antibodies)
Acan mRNA and protein was reduced by 50% in AgcCre/Cre mouse model of dwarfism. Analysis of gene expression indicates impaired differentiation of chondrocyte in hyaline cartilage of AgcCre/Cre mice.
As the primary site of agc1-deficiency is neuronal, this explains the lack of accumulation of brain lactate in agc1-deficiency in humans and mice.
Aggrecan has a major role in regulating the expression of key growth factors and signaling molecules during development of cartilaginous tissue and is essential for proper chondrocyte organization, morphology, and survival.
Aggrecan, link protein (show HAPLN1 Antibodies) and TN-R (show TNR Antibodies) were identified to be essential for the neuroprotective properties of the perineuronal net.
the subsequent presentation of aggregan from ECM (show MMRN1 Antibodies) leads to CD4 (show CD4 Antibodies)(+) T-cell activation and effector cell formation.
Runx3 (show RUNX3 Antibodies) positively regulates aggrecan expression and suggest that its function is more limited to cartilage development than to bone.
The role of ADAMTS5 (show ADAMTS5 Antibodies) in tendon is to remove pericellular and interfibrillar aggrecan to maintain the molecular architecture responsible for normal tissue function.
role of ADAMTS5 (show ADAMTS5 Antibodies) in dermal repair through CD44 (show CD44 Antibodies)-mediated aggrecan accumulation and modulation of transforming growth factor beta1 (TGFbeta1 (show TGFB1 Antibodies)) signaling
CSGalNAcT-1 (show CSGALNACT1 Antibodies) is necessary for normal levels of endochondral ossification, and the decrease in CS amount in the growth plate by its absence causes a rapid catabolism of aggrecan.
Data show that expression of mRNAs for aggrecan, collagen type II, and versican (show Vcan Antibodies) were significantly effected by the intervention.
The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (show ADAMTS5 Antibodies) (aggrecanase (show ADAMTS4 Antibodies)) explains the minor contribution of the MMP enzymes to aggrecan catabolism in vivo.
Self-adhesion between highly negatively charged aggrecan macromolecules extracted from bovine cartilage extracellular matrix, was investigated.
aggrecanase (show ADAMTS4 Antibodies) activity (a) is responsible for early TNFalpha (show TNF Antibodies)-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.
Maintenance of structure and organization of extracellular matrix comprising chondron and pericellular microenvironment of chondrocytes in articular cartilage is important for distribution of newly synthesized aggrecan monomers within tissue.
aggrecan plays a protective role in preventing degradation of collagen fibrils
Changes in aggrecan and type II collagen (show COL2A1 Antibodies) promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations.
AGC1 mRNA expression level was upregulated by multidirectional articular motion.
Homozygosity mapping in candidate regions in a small Dexter pedigree suggested aggrecan as the most likely candidate gene. Mutation screening revealed a 4-bp insertion in exon 11 (2266_2267insGGCA) and a second, rarer transition in exon 1 (-198C>T).
keratan sulphate in the interglobular domain of pig aggrecan has a microstructure that is distinct from keratan sulphate in the keratan sulphate-rich region
Aggrecan synthesis in intervertebral disc cells is stimulated by E-cadherin (show CDH1 Antibodies).
Aggrecan (ACAN) was a candidate gene in that region, and exons were sequenced to compare DNA sequences for dwarf (show POU1F1 Antibodies) and non-dwarf (show POU1F1 Antibodies) horses. Sequencing led to the discovery of variants in exons 2, 6, 7 and 15 associated with dwarfism.
he dwarf (show POU1F1 Antibodies) Miniature Shetland pony had the homozygous mutant genotype C/C of the ACAN:g.94370258G>C variant and the normal parents were heterozygous G/C. An unaffected full sib and 3/5 unaffected half-sibs were heterozygous G/C for the ACAN:g.94370258G>C variant. In summary, we could demonstrate a dwarf (show POU1F1 Antibodies) phenotype in a miniature pony breed perfectly associated with a missense mutation within the ACAN gene.
At 0.1 and 1 microM concentrations, LE135 weakly but significantly increased chondral morphology scores, compared to untreated controls. Lack of aggrecan expression and lack of increased CII:CI ratio, compared to controls, did not affect chondrogenesis.
degenerative suspensory ligament desmitis ligaments showed a 15-fold increase in aggrecan compared to normal
This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.
aggrecan core protein
, cartilage-specific proteoglycan core protein
, chondroitin sulfate proteoglycan core protein 1
, large aggregating proteoglycan
, aggrecan 1
, aggrecan, structural proteoglycan of cartilage
, aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122)
, aggrecan epidermal growth factor-like domain-1
, chondroitin sulfate proteoglycan core protein
, cartilage aggregating proteoglycan
, chondroitin sulfate proteoglycan 1
, large aggregating proteoglycan, antigen
, aggrecan core protein-like
, aggrecan interglobular domain