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Human CD44 Protein expressed in Wheat germ - ABIN1348653
Gebhard, Jain, Nair, Emmons, Argilagos, Koomen, McLaughlin, Hazlehurst: MTI-101 (cyclized HYD1) binds a CD44 containing complex and induces necrotic cell death in multiple myeloma. in Molecular cancer therapeutics 2013
Show all 2 Pubmed References
Human CD44 Protein expressed in HEK-293 Cells - ABIN2180800
Hanley, Burdick, Konstantopoulos, Sackstein: CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity. in Cancer research 2005
Show all 2 Pubmed References
Human CD44 Protein expressed in HEK-293 Cells - ABIN2713719
Zhang, Jia, Wang, Li, Hou, Yin, Wang, He, Lu: A CD44 specific peptide developed by phage display for targeting gastric cancer. in Biotechnology letters 2015
The genotypes CT, CT+TT, TT, and allele T in rs13347 of CD44 may be risk factors for breast cancer.
Peripheral blood lymphocyte subsets in patients with lung cancer are different from those in healthy people, and circulating CD44+ and CD54 (show ICAM1 Proteins)+ lymphocytes seem to be a promising criterion to predict survival in lung cancer patients undergoing chemotherapy
CD44 regulated TLR2 responses in human macrophages, whereby a reduction in CD44 levels or engagement of CD44 by its ligand (HA) or a CD44-specific Ab reduced NF-kappaB (show NFKB1 Proteins) translocation and downstream proinflammatory cytokine production.
Our results suggested that CD44 expression could be used as a marker for the prediction of gastric cancer development, particularly in patients with precancerous gastric lesions carrying AG or GG, who were selected to surveillance follow-up for gastric cancer prevention.
CD44 polymorphism rs13347 acts as a risk factor for cancer, especially in Chinese, while the minor allele of polymorphism rs11821102 may be associated with a decreased susceptibility to cancer
ntermediate Molecular Mass Hyaluronan and CD44 interactions on PMNs potently elicit F-actin cytoskeleton polymerization and p38 (show CRK Proteins)- and ERK1/2-MAPK (show MAPK1 Proteins) phosphorylation to enhance PMN (show TBCE Proteins) function.
CD44v9 in tumor specimens has potential as a novel indicator for identifying a cisplatin-chemoresistant population among urothelial cancer patients. CD44v8-10 contributes to reactive oxygen species defenses, which are involved in chemoresistance, by promoting the function of xCT (show SLC7A11 Proteins), which adjusts the synthesis of glutathione.
CD44 standard isoform was especially upregulated after high-dose X-ray irradiation.
Upregulated miR (show MLXIP Proteins)-373 levels and simultaneously downregulated levels of CD44 and E-cadherin (show CDH1 Proteins) were noted in this study.
MiRNA-34a suppresses invasion and metastatic in esophageal squamous cell carcinoma by regulating CD44.
We show here that cleavage-stimuli-induced specific ICD-modifications cause structural substrate changes that enhance ectodomain sensitivity of neuregulin-1 (NRG1 (show NRG1 Proteins); epidermal-growth-factor (show EGF Proteins)) or CD44 (receptor-tyrosine-kinase (show ERBB3 Proteins) (RTK) co-receptor) to chymotrypsin/trypsin or soluble ADAM.
TGF-beta1 (show TGFB1 Proteins)-mediated hyaluronan/CD44/STAT3 (show STAT3 Proteins) signaling pathway plays a crucial role in the development of atrial fibrosis and atrial fibrillation.
The role of CD44 was evaluated in CD44(-/-) challenged with a methionine- and choline-deficient diet (MCDD). Liver inflammation, liver injury and fibrosis strongly decreased in CD44(-/-) mice compared to wild-type mice on MCDD.
Data (including data from studies using transgenic mice) suggest that a single oral dose of vitamin A (1) amplifies tolerogenic activity of dendritic cells migrating to lymphoid tissue and (2) up-regulates expression of Foxp3 (show FOXP3 Proteins) and Cd44 in co-cultures of dendritic cells and CD4 (show CD4 Proteins)+ lymphocytes. (Foxp3 (show FOXP3 Proteins) = forkhead box P3 (show FOXP3 Proteins); Cd44 = homing receptor)
The pseudo-hypoxic phenotype of stem-like glioma cells is achieved by stabilization of HIF-2a through interaction with CD44, independently of oxygen.
These results suggest that CD44(+)CD117(+) T cells are stem cells and a specific T-cell phenotype that initially develops in the thymus, but they do not progress through DN3 and DN4 stages, lack a DP stage, and potently suppress T-cell proliferation and modulate the CTLA-4 (show CTLA4 Proteins) pathway.
the survival outcomes of genetically induced glioma-bearing mice and of high-grade human glioma patients are biphasically correlated with CD44 level, with the poorest outcomes occurring at intermediate levels.
pERK1/2 is a regulator of CD44 expression, and increased CD44 expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
MET signaling regulates intestinal homeostasis and regeneration, as well as adenoma formation. These activities of MET are promoted by the stem cell CD44 isoform CD44v4-10.
study demonstrates that CD44 plays a critical role in the regulation of experimental autoimmune encephalomyelitis through alterations in the gut microbiome profile and short-chain fatty acid production
An important role for the Hyaluronan-CD44 signaling pathway in reproductive function and inflammation.
Increased CD44s protein and posttranslational modification of CD44 with polylactosamine on macrophages from stage III could be involved in the cleaning up apoptotic granulosa cells
CD44 has a key role in oocyte maturation but not in cumulus expansion.
This study demonstrates that the CD14 (show CD14 Proteins)-negative isolation yields an enhanced cell population SFB (show CEBPB Proteins) that is more potent than MSCP (show SLC25A37 Proteins) as a cell source for cartilage tissue engineering.
CD44 is expressed in the cumulus-oocyte complexes during cumulus expansion. The interaction between hyaluronan and CD44 is closely related to gap junctional communication of the cumulus-oocyte complexes during meiotic resumption.
CD44 knock-down in bovine and human chondrocytes results in release of bound HYAL2 (show HYAL2 Proteins).
release of the CD44 intracellular domain into the cytoplasm of cells such as chondrocytes exerts a competitive or dominant-negative effect on the function of full-length CD44.
CD44 fragmentation, consistent with a signature pattern reported for sequential metalloproteinase/gamma-secretase cleavage of CD44, is a common metabolic feature of chondrocytes that have undergone dedifferentiation in vitro
determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25 (show IL2RA Proteins), CD44, and CD62L (show SELL Proteins) expression on peripheral blood T-cell subsets from M. bovis-infected cattle.
detection of CD44 in the bovine oviductal epithelium
Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM (show HMMR Proteins)-mediated signalling pathways involving Cdc2 (show CDK1 Proteins) and gamma-adducin (show ADD3 Proteins).
The novel finding that TSP-1 (show THBS1 Proteins)-induced migration is dependent on the CD44 receptor links 2 pathways thought to be disparate (ie, TSP-1 (show THBS1 Proteins) and HyA (show KDM5D Proteins)).
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
, GP90 lymphocyte homing/adhesion receptor
, Hermes antigen
, cell surface glycoprotein CD44
, chondroitin sulfate proteoglycan 8
, extracellular matrix receptor III
, hematopoietic cell E- and L-selectin ligand
, heparan sulfate proteoglycan
, homing function and Indian blood group system
, hyaluronate receptor
, phagocytic glycoprotein 1
, hermes antigen
, lymphocyte antigen 24
, phagocytic glycoprotein I
, Cell surface glycoprotein CD44 (hyaluronate binding protein)
, CD44-like protein
, extracellular matrix receptor-III
, lymphocyte surface antigen precursor CD44
, CD44 molecule (Indian blood group) S homeolog
, hyaluronan receptor CD44