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Human CD44 Protein expressed in Wheat germ - ABIN1348653
Gebhard, Jain, Nair, Emmons, Argilagos, Koomen, McLaughlin, Hazlehurst: MTI-101 (cyclized HYD1) binds a CD44 containing complex and induces necrotic cell death in multiple myeloma. in Molecular cancer therapeutics 2013
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Human CD44 Protein expressed in HEK-293 Cells - ABIN2180800
Hanley, Burdick, Konstantopoulos, Sackstein: CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity. in Cancer research 2005
Show all 2 Pubmed References
Human CD44 Protein expressed in HEK-293 Cells - ABIN2713719
Zhang, Jia, Wang, Li, Hou, Yin, Wang, He, Lu: A CD44 specific peptide developed by phage display for targeting gastric cancer. in Biotechnology letters 2015
Reports indicate that high CD44 expression in ascites tumor cells (ATC (show SRPK1 Proteins)) correlates with CSC and EMT (show ITK Proteins) phenotype, both regulated by the tumor microenvironment through several signaling pathways, including the TGF-beta (show TGFB1 Proteins) signaling pathway.
Data identified Twist1 (show TWIST1 Proteins) and CD44 as novel REST targeted genes and provide new insight into the epigenetic regulation of Twist1 (show TWIST1 Proteins) and CD44 by REST.
Data show increased CD44 levels in ovarian cancer patient samples correlated with enhanced expression of the mesenchymal spliced variant CD44s (standard) and a concurrent decrease in the epithelial variants (CD44v). Moreover, CD44s was upregulated upon TGFbeta1 (show TGFB1 Proteins)-induced EMT (show ITK Proteins), which was mediated through the downregulation of the splicing factor (show SLU7 Proteins), ESRP1 (show ESRP1 Proteins). Overexpression of CD44s induced EMT (show ITK Proteins), invasion, and chemoresistance.
The current evidence suggests that CD44 is an efficient prognostic factor in pancreatic cancer.
the CD44-NRF2 axis might be a promising therapeutic target for the control of stress resistance and survival of CD44(high) CSC population within breast tumors.
These results reveal a novel positive feedback loop involving CD44S and YAP1 (show YAP1 Proteins), in which CD44S functions as both an upstream regulator and a downstream effector of YAP1 (show YAP1 Proteins) in hepatocellular carcinoma.
CHI3L1 (show CHI3L1 Proteins) expression is a novel biomarker for the prognosis of gastric cancer and these findings have thus identified CHI3L1 (show CHI3L1 Proteins)/CD44 axis as a vital pathway and potential therapeutic target in gastric cancer .
The selective binding of HA-CH-NP/siRNA to CD44-positive tumor endothelial cells.
Results showed that the expression of IGF1R (show IGF1R Proteins) appears to be highly correlated with the expression of ABCG2 in osteosarcoma and with the expression of CD44 in osteosarcoma patients under age of 10.
CD44 Polymorphisms are associated with Gastric Cancer.
We show here that cleavage-stimuli-induced specific ICD-modifications cause structural substrate changes that enhance ectodomain sensitivity of neuregulin-1 (NRG1 (show NRG1 Proteins); epidermal-growth-factor (show EGF Proteins)) or CD44 (receptor-tyrosine-kinase (show ERBB3 Proteins) (RTK) co-receptor) to chymotrypsin/trypsin or soluble ADAM.
TGF-beta1 (show TGFB1 Proteins)-mediated hyaluronan/CD44/STAT3 (show STAT3 Proteins) signaling pathway plays a crucial role in the development of atrial fibrosis and atrial fibrillation.
The role of CD44 was evaluated in CD44(-/-) challenged with a methionine- and choline-deficient diet (MCDD). Liver inflammation, liver injury and fibrosis strongly decreased in CD44(-/-) mice compared to wild-type mice on MCDD.
Data (including data from studies using transgenic mice) suggest that a single oral dose of vitamin A (1) amplifies tolerogenic activity of dendritic cells migrating to lymphoid tissue and (2) up-regulates expression of Foxp3 (show FOXP3 Proteins) and Cd44 in co-cultures of dendritic cells and CD4 (show CD4 Proteins)+ lymphocytes. (Foxp3 (show FOXP3 Proteins) = forkhead box P3 (show FOXP3 Proteins); Cd44 = homing receptor)
The pseudo-hypoxic phenotype of stem-like glioma cells is achieved by stabilization of HIF-2a through interaction with CD44, independently of oxygen.
These results suggest that CD44(+)CD117(+) T cells are stem cells and a specific T-cell phenotype that initially develops in the thymus, but they do not progress through DN3 and DN4 stages, lack a DP stage, and potently suppress T-cell proliferation and modulate the CTLA-4 (show CTLA4 Proteins) pathway.
the survival outcomes of genetically induced glioma-bearing mice and of high-grade human glioma patients are biphasically correlated with CD44 level, with the poorest outcomes occurring at intermediate levels.
pERK1/2 is a regulator of CD44 expression, and increased CD44 expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
MET signaling regulates intestinal homeostasis and regeneration, as well as adenoma formation. These activities of MET are promoted by the stem cell CD44 isoform CD44v4-10.
study demonstrates that CD44 plays a critical role in the regulation of experimental autoimmune encephalomyelitis through alterations in the gut microbiome profile and short-chain fatty acid production
An important role for the Hyaluronan-CD44 signaling pathway in reproductive function and inflammation.
Increased CD44s protein and posttranslational modification of CD44 with polylactosamine on macrophages from stage III could be involved in the cleaning up apoptotic granulosa cells
CD44 has a key role in oocyte maturation but not in cumulus expansion.
This study demonstrates that the CD14 (show CD14 Proteins)-negative isolation yields an enhanced cell population SFB (show CEBPB Proteins) that is more potent than MSCP (show SLC25A37 Proteins) as a cell source for cartilage tissue engineering.
CD44 is expressed in the cumulus-oocyte complexes during cumulus expansion. The interaction between hyaluronan and CD44 is closely related to gap junctional communication of the cumulus-oocyte complexes during meiotic resumption.
CD44 knock-down in bovine and human chondrocytes results in release of bound HYAL2 (show HYAL2 Proteins).
release of the CD44 intracellular domain into the cytoplasm of cells such as chondrocytes exerts a competitive or dominant-negative effect on the function of full-length CD44.
CD44 fragmentation, consistent with a signature pattern reported for sequential metalloproteinase/gamma-secretase cleavage of CD44, is a common metabolic feature of chondrocytes that have undergone dedifferentiation in vitro
determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25 (show IL2RA Proteins), CD44, and CD62L (show SELL Proteins) expression on peripheral blood T-cell subsets from M. bovis-infected cattle.
detection of CD44 in the bovine oviductal epithelium
Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM (show HMMR Proteins)-mediated signalling pathways involving Cdc2 (show CDK1 Proteins) and gamma-adducin (show ADD3 Proteins).
The novel finding that TSP-1 (show THBS1 Proteins)-induced migration is dependent on the CD44 receptor links 2 pathways thought to be disparate (ie, TSP-1 (show THBS1 Proteins) and HyA (show KDM5D Proteins)).
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
, GP90 lymphocyte homing/adhesion receptor
, Hermes antigen
, cell surface glycoprotein CD44
, chondroitin sulfate proteoglycan 8
, extracellular matrix receptor III
, hematopoietic cell E- and L-selectin ligand
, heparan sulfate proteoglycan
, homing function and Indian blood group system
, hyaluronate receptor
, phagocytic glycoprotein 1
, hermes antigen
, lymphocyte antigen 24
, phagocytic glycoprotein I
, Cell surface glycoprotein CD44 (hyaluronate binding protein)
, CD44-like protein
, extracellular matrix receptor-III
, lymphocyte surface antigen precursor CD44
, CD44 molecule (Indian blood group) S homeolog
, hyaluronan receptor CD44