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Human CD44 Protein expressed in Wheat germ - ABIN1348653
Gebhard, Jain, Nair, Emmons, Argilagos, Koomen, McLaughlin, Hazlehurst: MTI-101 (cyclized HYD1) binds a CD44 containing complex and induces necrotic cell death in multiple myeloma. in Molecular cancer therapeutics 2013
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Human CD44 Protein expressed in HEK-293 Cells - ABIN2180800
Hanley, Burdick, Konstantopoulos, Sackstein: CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity. in Cancer research 2005
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Human CD44 Protein expressed in HEK-293 Cells - ABIN2713719
Zhang, Jia, Wang, Li, Hou, Yin, Wang, He, Lu: A CD44 specific peptide developed by phage display for targeting gastric cancer. in Biotechnology letters 2015
CD44 isoform specificity in CSC and non-CSC states and suggest that alternative splicing provides functional gene versatility that is essential for distinct cancer cell states and thus cancer phenotypes.
High CD44 expression is associated with Muscle-Invasive Bladder Cancer.
Inhibition of miR-193a-3p in CD44(+) cells increased SRSF2 expression.
Targeted delivery of siRNA specific for CD44 can efficiently overcome resistance to EGFR targeting in TNBC cells.
There was no significant correlation between a positive expression of CD44 and the prognosis of patients (P>0.05). The expressions of HER4 and CD44 were not significantly correlated with sex, age, pigment, tumor site, etc. (P>0.05). Results further emphasize a correlation between HER4 and CD44 expressions in SNMMM tissues.
High CA19-9 levels, CD44 H-scores and poor differentiation are independent predictors for ER in PDAC patients undergoing radical resection. Therefore, the determination of CD44 expression might help in identifying patients at a high risk of ER for more aggressive treatment after radical surgery. .
CD44 silencing could inhibit the development of osteosarcoma migration, invasion, proliferation and ameliorate drug resistance to current treatment in osteosarcoma.
Study shows that fibroblastic reticular cells (FRCs) enhance HIV-1 spread via trans-infection in which FRCs capture HIV-1 and facilitate infection of T-cells that come into contact with FRCs. CD44 was identified as the host factor that accounts for the observed producer cell dependence of trans-infection.
we analysed the differential expression of CD44v at the mRNA level in patients with AGC and compared this with the expression of standard CD44s. Based on differences in the CD44v profile, we demonstrated that the CD44v8-10 isoform is a potential therapeutic target using NIR fluorophore or photosensitiser-conjugated anti-CD44v9 antibody.
DACH1 and CD44 inversely related in breast cancer, different grade tumors and different subtypes. DACH1 was negatively associated with CD44 in vitro and vivo. DACH1 served as a good prognostic marker, and CD44 was an unfavorable element of breast cancer patients.
Interleukin-4 induces a CD44high /CD49bhigh PC3 subpopulation with tumor-initiating characteristics.
we demonstrated that miR711mediated downregulation of CD44 expression inhibited EMT of gastric cancer cells in vitro and in vivo by downregulating vimentin protein expression and upregulating Ecadherin protein expression through transfection, qRTPCR and western blotting.
Expression levels of MACC1, CD44, Twist1, and KiSS-1 are related to duration of overall survival among patients with colonic adenocarcinoma.
miR-218-5p was downregulated in invasion front cells and negatively regulates oral squamous cell carcinoma invasiveness by targeting the CD44-ROCK pathway.
our study demonstrated that miR-520b inhibits the malignancy of HNC through regulation of cancer stemness conversion by targeting CD44.
The work identified two new host factors that may act as receptors for P. falciparum during invasion: CD44 and CD55. (Review)
Reports indicate that high CD44 expression in ascites tumor cells (ATC) correlates with CSC and EMT phenotype, both regulated by the tumor microenvironment through several signaling pathways, including the TGF-beta signaling pathway.
Data identified Twist1 and CD44 as novel REST targeted genes and provide new insight into the epigenetic regulation of Twist1 and CD44 by REST.
Data show increased CD44 levels in ovarian cancer patient samples correlated with enhanced expression of the mesenchymal spliced variant CD44s (standard) and a concurrent decrease in the epithelial variants (CD44v). Moreover, CD44s was upregulated upon TGFbeta1-induced EMT, which was mediated through the downregulation of the splicing factor, ESRP1. Overexpression of CD44s induced EMT, invasion, and chemoresistance.
The current evidence suggests that CD44 is an efficient prognostic factor in pancreatic cancer.
The hyaluronan-binding CD44(+/+) CD8 effector T cells showed increased pAkt expression, higher glucose uptake, and were more susceptible to cell death during the contraction phase compared to non-binding CD44(+/+) and CD44(-/-) OT-I CD8 T cells, suggesting that CD44 and its engagement with hyaluronan skews CD8 T cells toward a terminal effector differentiation state that reduces their ability to form memory cells.
CD44 functions as a picket, affixing the cortical actin cytoskeleton to the membrane. The extracellular domain of CD44 binds hyaluronan, which forms a pericellular coat.
this study shows that absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis
this study demonstrates a new role for CD44 and hyaluronan in promoting alveolar macrophage survival
CD44-positive proliferating glomerular cells, most likely parietal epithelial cells, are essential in the pathogenesis of scarring glomerular disease.
We show here that cleavage-stimuli-induced specific ICD-modifications cause structural substrate changes that enhance ectodomain sensitivity of neuregulin-1 (NRG1; epidermal-growth-factor) or CD44 (receptor-tyrosine-kinase (RTK) co-receptor) to chymotrypsin/trypsin or soluble ADAM.
TGF-beta1-mediated hyaluronan/CD44/STAT3 signaling pathway plays a crucial role in the development of atrial fibrosis and atrial fibrillation.
The role of CD44 was evaluated in CD44(-/-) challenged with a methionine- and choline-deficient diet (MCDD). Liver inflammation, liver injury and fibrosis strongly decreased in CD44(-/-) mice compared to wild-type mice on MCDD.
Data (including data from studies using transgenic mice) suggest that a single oral dose of vitamin A (1) amplifies tolerogenic activity of dendritic cells migrating to lymphoid tissue and (2) up-regulates expression of Foxp3 and Cd44 in co-cultures of dendritic cells and CD4+ lymphocytes. (Foxp3 = forkhead box P3; Cd44 = homing receptor)
The pseudo-hypoxic phenotype of stem-like glioma cells is achieved by stabilization of HIF-2a through interaction with CD44, independently of oxygen.
These results suggest that CD44(+)CD117(+) T cells are stem cells and a specific T-cell phenotype that initially develops in the thymus, but they do not progress through DN3 and DN4 stages, lack a DP stage, and potently suppress T-cell proliferation and modulate the CTLA-4 pathway.
the survival outcomes of genetically induced glioma-bearing mice and of high-grade human glioma patients are biphasically correlated with CD44 level, with the poorest outcomes occurring at intermediate levels.
pERK1/2 is a regulator of CD44 expression, and increased CD44 expression leads to a pro-sclerotic and migratory parietal epithelial cell phenotype in focal segmental glomerulosclerosis.
MET signaling regulates intestinal homeostasis and regeneration, as well as adenoma formation. These activities of MET are promoted by the stem cell CD44 isoform CD44v4-10.
study demonstrates that CD44 plays a critical role in the regulation of experimental autoimmune encephalomyelitis through alterations in the gut microbiome profile and short-chain fatty acid production
CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium.
OA/GPNMB acts through ERK and AKT signaling pathways in mesenchymal stem cells via CD44
These findings support the usefulness of the conditional Cd44 allele in unraveling essential physiological and pathological functions of CD44 isoforms.
CD44 role in the atrophic epidermis
CD44(high) type II cells likely represent a type II cell subpopulation important for constitutive regulation of alveolar homeostasis.
An important role for the Hyaluronan-CD44 signaling pathway in reproductive function and inflammation.
Increased CD44s protein and posttranslational modification of CD44 with polylactosamine on macrophages from stage III could be involved in the cleaning up apoptotic granulosa cells
CD44 has a key role in oocyte maturation but not in cumulus expansion.
This study demonstrates that the CD14-negative isolation yields an enhanced cell population SFB that is more potent than MSCP as a cell source for cartilage tissue engineering.
CD44 is expressed in the cumulus-oocyte complexes during cumulus expansion. The interaction between hyaluronan and CD44 is closely related to gap junctional communication of the cumulus-oocyte complexes during meiotic resumption.
CD44 knock-down in bovine and human chondrocytes results in release of bound HYAL2.
release of the CD44 intracellular domain into the cytoplasm of cells such as chondrocytes exerts a competitive or dominant-negative effect on the function of full-length CD44.
CD44 fragmentation, consistent with a signature pattern reported for sequential metalloproteinase/gamma-secretase cleavage of CD44, is a common metabolic feature of chondrocytes that have undergone dedifferentiation in vitro
determined the effects of Mycobacterium-induced proliferation and apoptosis on CD25, CD44, and CD62L expression on peripheral blood T-cell subsets from M. bovis-infected cattle.
detection of CD44 in the bovine oviductal epithelium
Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 and RHAMM-mediated signalling pathways involving Cdc2 and gamma-adducin.
The novel finding that TSP-1-induced migration is dependent on the CD44 receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA).
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
, GP90 lymphocyte homing/adhesion receptor
, Hermes antigen
, cell surface glycoprotein CD44
, chondroitin sulfate proteoglycan 8
, extracellular matrix receptor III
, hematopoietic cell E- and L-selectin ligand
, heparan sulfate proteoglycan
, homing function and Indian blood group system
, hyaluronate receptor
, phagocytic glycoprotein 1
, hermes antigen
, lymphocyte antigen 24
, phagocytic glycoprotein I
, Cell surface glycoprotein CD44 (hyaluronate binding protein)
, CD44-like protein
, extracellular matrix receptor-III
, lymphocyte surface antigen precursor CD44
, CD44 molecule (Indian blood group) S homeolog
, hyaluronan receptor CD44