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anti-Mouse (Murine) CRIM1 Antibodies:
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Human Polyclonal CRIM1 Primary Antibody for IHC, IHC (p) - ABIN4300479
Nyström, Hultenby, Ek, Sjölund, Axelson, Jirström, Saleem, Nilsson, Johansson: CRIM1 is localized to the podocyte filtration slit diaphragm of the adult human kidney. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009
Show all 4 Pubmed References
Human Polyclonal CRIM1 Primary Antibody for IF (p), IHC (p) - ABIN676853
Zeng, Zhang, Yi, Wu, Wan, Tang: CRIM1, a newfound cancer-related player, regulates the adhesion and migration of lung cancer cells. in Growth factors (Chur, Switzerland) 2016
these findings implicate CRIM1 in endothelial cell development and homeostasis in the coronary vasculature.
Collectively, our data demonstrates that Crim1 is essential for cell-autonomous and paracrine aspects of heart development
Crim1 regulates integrin signaling in murine lens development
CRIM1 is the causative gene for Colobomatous macrophthalmia with microcornea syndrome and is important for eye development.
Vascular endothelial cell-specific conditional compound heterozygotes for Crim1 and Vegfa exhibit a phenotype that is more severe than each single heterozygote and indistinguishable from that of the conditional homozygotes.
Report the involvement of both endothelial cells and monocytes in the development of progressive renal fibrosis in Crim1 mutant mice.
Crim1 mutations are associated with defects in papillary development and progression to chronic kidney disease later in life.
Crim1 is required for placental development, and is necessary for the proper differentiation of sinusoidal-trophoblast giant cells and glycogen trophoblast cells.
CRIM1 has a role in capillary formation and maintainance during angiogenesis
CRIM1 modulates BMP activity by affecting its processing and delivery to the cell surface
Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems.
Crim1 regulates the delivery of VEGF-A by the podocytes to the endothelial cells
primary role of zebrafish crim1 is likely to be the regulation of somitic and vascular development
CRIM1 regulates the expression of several epithelial-mesenchymal transition (EMT) related factors and appears to play a role in suppressing migration and invasion through control of EMT.
These observations provide evidence for the first time that CRIM1 plays a role in cancer cells by enhancing the migration and adhesion and increasing the expression of N-CAD and E-CAD.
Knock down of CRIM1 had no effect on VEGF-induced proliferation or migration of umbilical vein endothelial cells (HUVECs), indicating that basal CRIM1 is not involved in the proliferation or migration of endothelial cells.
Data suggest that CRIM1 plays role in cancer progression/metastasis, epithelial-mesenchymal transition, and neoplastic angiogenesis. [REVIEW]
BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF.
CRIM1 is an early response gene in the presence of both angiogenic stimulation (VEGF) and environmental (extracellular matrix) factors, and Erk and FAK might be involved in the upregulation of CRIM1 mRNA expression in vascular endothelial cells.
Study demonstrated that CRIM1 is expressed at high levels in resistant leukemia cells, indicating that CRIM1 may play a role in drug-resistance.
CRIM1 has a role in capillary formation and maintenance during angiogenesis
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins.
cysteine rich transmembrane BMP regulator 1 (chordin-like)
, cysteine-rich motor neuron 1 protein
, cysteine-rich motor neuron 1
, cysteine-rich motor neuron 1 protein-like
, cysteine rich transmembrane BMP regulator 1
, cysteine-rich repeat-containing protein S52
, cysteine-rich motorneuron 1