CRIM1 antibody (C-Term)

Catalog No. ABIN1449941

The Rabbit Polyclonal anti-CRIM1 antibody is suitable to detect CRIM1 in samples from Human. It has been validated for WB, IF and EIA.

Quick Overview for CRIM1 antibody (C-Term) (ABIN1449941)

Target: CRIM1 (Cysteine Rich Transmembrane BMP Regulator 1 (Chordin-Like) (CRIM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRIM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-CRIM1 Antibody

Binding Specificity: C-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: 17 amino acid synthetic peptide near the carboxy terminus of Human CRIM1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CRIM1

Target: CRIM1 (Cysteine Rich Transmembrane BMP Regulator 1 (Chordin-Like) (CRIM1))

Alternative Name: CRIM1

Background: CRIM1 (cysteine-rich motor neuron 1), a glycosylated type I transmembrane protein, plays a role in tissue development i.e. capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. CRIM1 is developmentally expressed in a number of tissues including the pancreas, kidney, placenta, brain and blood vessels. CRIM1 may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.Synonyms: CRIM-1, Cysteine-rich motor neuron 1 protein, S52

Gene ID: 51232

NCBI Accession: NP_057525

Pathways: Growth Factor Binding