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Human HTRA1 Protein expressed in Escherichia coli (E. coli) - ABIN368668
Frochaux, Hildebrand, Talke, Linscheid, Schlüter: Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue. in PLoS ONE 2014
HtrA1 is indispensable for dorsoventral patterning in early zebrafish embryogenesis and serves as a key upstream regulator of FGF signaling through the control of FGF levels.
Our data point to a yet unexpected effect of decreased HTRA1 expression on drusen pathogenesis. Thus not only a higher HTRA1 expression, but an imbalance of HTRA1 might be disease-relevant.
Tests for association revealed a variant in the promoter region of HTRA1 and two variants in the 5'-UTR of ARMS2 (show ARMS2 Proteins) to be associated with drusen.
As in humans, one variant within LOC387715/ARMS2 (show ARMS2 Proteins) and one in HTRA1 were significantly associated with age-related macular degeneration.
These findings suggest that the variation in the risk for age-related macular degeneration associated with chromosome 10q26 is likely due to variation in HTRA1 expression.
HtrA1 role in the cisplatin resistance in colon cancer
HtrA1 could serve as a marker to identify ulcerative colitis of >10 year duration patients at high risk of developing colorectal cancer.
because the ARMS2 (show ARMS2 Proteins)/HTRA1 genes are positioned at a locus on chromosome 10q26 in a region with strong linkage disequilibrium, it is difficult to distinguish the functions of the individual genes. a review of recent epidemiological studies of Age-related macular degeneration(AMD (show AMD1 Proteins)) is offered. An argument for a definite correlation between the ARMS2 (show ARMS2 Proteins) gene and AMD (show AMD1 Proteins) is presented
The expression of HtrA1 was strongly related to the T2 value, suggesting that HtrA1 plays an important role in the pathological process of intervertebral disc degeneration.
These data implicate HTRA1 as a negative regulator of mesenchymal stem cell adipogenesis.
These results suggest that the initiation stage of polypoidal choroidal vasculopathy is mediated by proteolytic degradation of extracellular matrix proteins attributable to increased HTRA1 activity
The findings of the present study provide evidence that CFH (show CFH Proteins) gene variants and ARMS2 (show ARMS2 Proteins)/HTRA1 genes play a major role in the genetic susceptibility to AMD (show AMD1 Proteins) in a Greek population. These findings are of direct relevance for disease and help mapping the genetic chart of AMD (show AMD1 Proteins).
The function of the binding between MIF (show AMH Proteins) and HTRA1 is to inhibit the proteolytic activity of HTRA1.
Results show that HTRA1 is epigenetically silenced in HCT116 colon carcinoma cells and during early stages of tumorigenesis in a mouse model of intestinal cancer. Downregulation of HTRA1 causes a multiple phenotypes that are hallmarks of cancer cells including increased proliferation of mouse embryonic fibroblasts, as well as chromosome and centrosome amplifications.
transfection of cells with a constitutively active rapamycin-resistant p70S6K (show RPS6KB1 Proteins) mutant could restore the mineralizing capacity of HtrA1-deficient mouse adipose-derived stromal cells.
Increased expressions of Tgf-beta1 (show TGFB1 Proteins), p-Smad2 (show SMAD2 Proteins)/3 and HtrA1 were detected in the articular chondrocytes of knee joints in models of osteoarthritis.
In mouse brain tissue and embryonic fibroblasts there is a facilitating role of HtrA1 in TGF-beta (show TGFB1 Proteins) pathway activation.
HtrA1 plays important roles in the differentiation of trophoblasts from Tpbpa-positive precursors in the ectoplacental cone
The HtrA1 overexpression and mainstream cigarette smoke can independently lead to CNV. The HtrA1 gene is a strong risk factor for wet AMD (show AMD1 Proteins)
the inhibitory effect of IFN-gamma (show IFNG Proteins) on HTRA1 expression was evidenced in collagen-induced arthritis (CIA (show NCOA5 Proteins)) mouse models and in human RA synovial cells.
Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.
Data show that HtrA1 is produced during osteoclastogenesis, and negatively regulates osteoblast differentiation, osteoblast differentiation and BMP2 (show BMP2 Proteins)-induced Smad1 (show SMAD1 Proteins)/5/8, ERK1/2 and p38 (show CRK Proteins) phosphorylation in pre-osteoblasts.
This study offers new insights into the regulation of HTRA-1 expression via LPS (show TLR4 Proteins)/TLR-4 (show TLR4 Proteins) and the role of HTRA-1 in rheumatoid arthrisis pathogenesis.
suggest a critical role for LRP1 (show LRP1 Proteins) in maintaining the integrity of vessels by regulating protease activity as well as matrix deposition by modulating HtrA1 and connective tissue growth factor (show CTGF Proteins) protein levels.
The results are consistent with a mechanism by which xHtrA1, through cleaving proteoglycans, releases cell-surface-bound Fibroblast Growth Factors (FGF) ligands and stimulates long-range FGF signaling.
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.
HtrA serine peptidase 1
, high-temperature requirement A serine peptidase 1A
, serine protease 11
, serine protease HTRA1A
, high-temperature requirement A serine peptidase 1B
, serine protease HTRA1B
, high temperature required A1
, Serine protease HTRA1
, high-temperature requirement A serine peptidase 1
, protease, serine, 11 (IGF binding)
, serine protease HTRA1
, insulin-like growth factor binding protein 5 protease
, protease, serine, 11 (Igf binding)
, IGF binding
, protease, serine, 11
, protease serine 11
, High-temperature requirement A serine peptidase 1
, Serine protease 11