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One paralog of mammalian wisp2 was found in zebrafish.
CCN3 (Nov (show NOV Proteins)) and CCN5 (WISP2) are novel substrates of MMP14 (show MMP14 Proteins).
Results show that WISP2 and beta-catenin (show CTNNB1 Proteins) were more highly expressed in gastric cancer tissues and seem to correlate with early stage or without metastasis.
Studies indicate that the CYR61 (show CYR61 Proteins) CTGF (show CTGF Proteins) NOV (show NOV Proteins) matricellular proteins (CCN family of proteins) comprises the members CCN1 (show CCNA2 Proteins), CCN2 (show CTGF Proteins), CCN3 (show NOV Proteins), CCN4 (show WISP1 Proteins), CCN5 and CCN6 (show WISP3 Proteins) and have been identified in various types of cancer.
Report opposing effects of CCN2 (show CTGF Proteins) and CCN5 on fibroblast proliferation and transdifferentiation induced by TGF-beta (show TGFB1 Proteins).
Serum WISP2 correlated directly with fatty acid binding protein 4. Serum SFRP5 (show SFRP5 Proteins) did not differ between obese (n=32) vs. nonobese (n=25) PCOS women, but reference women had lower SFRP5 (show SFRP5 Proteins) (p<5x10(-6) as compared to both PCOS groups).
Activation of CCN5 may have the therapeutic potential to kill triple-negative breast cancer.
WISP2 has a role in regulating tumor cell susceptibility through EMT (show ITK Proteins) by inducing the TGF-beta (show TGFB1 Proteins) signaling pathway, KLF-4 (show KLF4 Proteins) expression and miR-7 (show LILRB1 Proteins) inhibition.
overexpression of FGFBP1 (show FGFBP1 Proteins) or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer.
Loss of WISP2 in estrogen-dependent MCF7 human breast cancer cells promotes a stem-like cell phenotype.
We demonstrate that the overexpression of CCN5 in lung fibroblasts suppresses the upregulation in the expression of alpha-SMA (show SMN1 Proteins) and collagen induced by CCN2 (show CTGF Proteins).
Insulin (show INS Proteins)-like growth factor (IGF)-1 (show IGF1 Proteins) elicited clear stimulation of WNT1 inducible signaling pathway protein 2 (CCN5/WISP2) mRNA and protein levels in cultured islets.
Data suggest that CCN5, minimally expressed in unstimulated islet beta-cells, is strongly and directly induced by Igf1 (insulin-like growth factor I (show IGF1 Proteins)); overexpression of CCN5 stimulates cell proliferation and inhibits streptozotocin-induced apoptosis.
These results suggested that secreted Wisp2/CCN5 induces Akt (show AKT1 Proteins) and ERK (show EPHB2 Proteins) phosphorylation via integrins, and consequently facilitates neurite formation and conferred resistance to apoptosis.
CCN2 (show CTGF Proteins) is pro-hypertrophic and -fibrotic, whereas CCN5 is anti-hypertrophic and -fibrotic.
Although WISP-2 is a downstream protein of Wnt (show WNT2 Proteins) signaling, the role of WISP-2 on adipocyte differentiation may be marginal, at least in this in vitro culture model.
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
WNT1 inducible signaling pathway protein 2
, Wnt-1 inducible-signaling pathway protein 2
, WNT1 inducible signaling pathway 2
, CCN family member 5
, WNT1-inducible-signaling pathway protein 2
, connective tissue growth factor-like protein
, connective tissue growth factor-related protein 58
, wnt-1 signaling pathway protein 2
, CCN family protein COP-1