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anti-Human CK1 epsilon Antibodies:
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Human Polyclonal CK1 epsilon Primary Antibody for IHC (p), ELISA - ABIN543839
Keesler, Camacho, Guo, Virshup, Mondadori, Yao: Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon. in Neuroreport 2000
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Human Monoclonal CK1 epsilon Primary Antibody for IP, ELISA - ABIN534415
Hino, Michiue, Asashima, Kikuchi: Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. in The Journal of biological chemistry 2003
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Human Monoclonal CK1 epsilon Primary Antibody for IP, ELISA - ABIN534414
Knippschild, Gocht, Wolff, Huber, Löhler, Stöter: The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. in Cellular signalling 2005
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Dog (Canine) Polyclonal CK1 epsilon Primary Antibody for ELISA, WB - ABIN547906
Hämmerlein, Weiske, Huber: A second protein kinase CK1-mediated step negatively regulates Wnt signalling by disrupting the lymphocyte enhancer factor-1/beta-catenin complex. in Cellular and molecular life sciences : CMLS 2005
Human Polyclonal CK1 epsilon Primary Antibody for IHC (p), WB - ABIN391600
Gao, Inuzuka, Tseng, Chin, Toker, Wei: Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. in Nature cell biology 2009
Cow (Bovine) Polyclonal CK1 epsilon Primary Antibody for WB - ABIN2784724
Levran, Londono, OHara, Nielsen, Peles, Rotrosen, Casadonte, Linzy, Randesi, Ott, Adelson, Kreek: Genetic susceptibility to heroin addiction: a candidate gene association study. in Genes, brain, and behavior 2009
Findings in the dorsolateral prefrontal cortex in schizophrenia provide evidence of altered proteins involved in synaptic function (FABP4), cytoarchitecture organization (NEFH), and circadian molecular clock signaling (CSNK1E), which may be contributing to the cognitive and/or negative symptoms in this disorder. FABP4, CSNK1E and NEFH could become potentially useful biomarkers for schizophrenia.
low CK1epsilon expression is correlated with a low survival rate and CK1epsilon may play a role as a tumor suppressor in hepatocarcinogenesis.
Findings establish CK1varepsilon as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1varepsilon-mediated phosphorylation of TRAF3.
CSNK1E expression is associated with disease-free survival in breast cancer patients with wild-type p53 or poor histological differentiation or in those without adjuvant chemotherapy.
a 4-locus CSNK1E haplotype encompassing the rs1534891 SNP (Z-score=2.685, permuted p=0.0076) and a 3-locus haplotype in ARNTL (Z-score=3.269, permuted p=0.0011) showed a significant association with Bipolar Disorder
site-specific phosphorylation of adiponectin, especially at sites targeted by CK1delta in vitro, provides an additional regulatory mechanism for modulating adiponectin complex formation and function.
The dynamical and conformational properties for each of three isoforms of CK1 are explored through molecular dynamics (MD) simulations.
The results support our previous report of association of CSNK1E SNP rs1534891 with protection from heroin addiction. CSNK1E interacts with circadian rhythms and DARPP-32 and has been implicated in negative regulation of sensitivity to opioids in rodents.
CK1epsilon expression was higher in colorectal cancer tissues vs normal and was correlated with the Dukes staging and depth of invasion. Knockdown reduced cell proliferation and invasion and downregulated wnt3alpha, beta-catenin, PCNA and MMP-9.
Results indicate that changes in the expression levels of casein kinase 1 isoforms CK1delta and DK1epsilon in colorectal tumors correlate with patients' survival.
The loss of cytoplasmic CK1epsilon expression is greatly associated with poor survival and might be an adverse survival factor.
we validated the top two synthetic lethal gene pairs, CSNK1E-TP53 and CTNNB1-TP53, in colorectal cancer
CK1delta and CK1epsilon play a decisive role in triggering late steps of pre-40S maturation that are required for acquisition of functionality of 40S ribosomal subunits in protein translation.
Csnk1epsilon gene polymorphism (rs135745), especially the G allele, maybe associated with heroin dependence in the Han Chinese.
MST1 still inhibited the Wnt3A-induced phosphorylation of DVL2 (dishevelled 2) and Wnt/beta-catenin signalling by disturbing the interaction of DVL2 and CK1epsilon
CK1 epsilon(tau), as a gain-of-function mutation, acts at a specific circadian phase to promote degradation of PERIOD proteins and thereby accelerate the mammalian clockwork in brain and periphery.
No evidence is provided for the association between CK1epsilon gene and personality traits in healthy Chinese-Han subjects.
A genetic variant in the Csnk1epsilon gene significantly enhances the probability of schizophrenia in the Chinese Han population.
study identified DDX3 as a regulator of the Wnt-beta-catenin network, where it acts as a regulatory subunit of CK1epsilon: in a Wnt-dependent manner, DDX3 binds CK1epsilon and directly stimulates its kinase activity and promotes phosphorylation of the scaffold protein dishevelled
These results do not support that genetic variation in CSNK1D and CSNK1E is a susceptibility factor for major psychiatric disorders in the Japanese population.
CK1delta/epsilon disruption mouse had a long (27.4 h) behavioral period to which peripheral clocks entrained in vivo, albeit with an advanced phase ( approximately 6 h).
Studied roles of CK1delta and CK1e in regulation of PER2 in circadian rhythm.
the impact of obesity on the circadian system in mice at a behavioural and molecular level was assessed, and determined whether pharmacological targeting of casein kinase 1delta and epsilon (CK1delta/epsilon), key regulators of the circadian clock, can confer metabolic benefit.
Csnk1e deletion increased mu opioid receptor-dependent behaviors.
Here, the authors identify another Wnt signaling amplifier, CKIepsilon, which is specifically upregulated in intestinal stem cells and is essential for intestinal stem cell maintenance, especially in the absence of its close isoform CKIdelta.
Linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Csnk1e may contribute to individual differences in von Frey filament response.
mice bearing a short-period mutation in the enzyme casein kinase 1epsilon (tau mutation), which accelerates free-running circadian cycles, were investigated.
Data indicate period circadian proteins PER1 and PER2 as direct substrates of casein kinase 1epsilon (CK1epsilon).
Integrated genetic approaches identify the molecular mechanisms of Sox4 in early B-cell development: intricate roles for RAG1/2 and CK1epsilon.
A narrow genetic locus containing Csnk1e is associated with differences in sensitivity to methamphetamine (MA) and fentanyl; variation at the Csnk1e locus can regulate the locomotor response to MA.
Identification of a novel Wnt5a-CK1varepsilon-Dvl2-Plk1-mediated primary cilia disassembly pathway.
The results suggest that CK1delta/epsilon binds to and phosphorylates the N-terminal domain of Dnmt1 and regulates Dnmt1 function by reducing the DNA-binding activity.
physical interaction between PER and CKIdelta/epsilon required for circadian rhythm
Cell/organ type-specific function of CK1epsilon indicate that tumorigenic conversion of mammary glands in SV40 T-antigen-transgenic mice leads to downregulation of CK1epsilon.
Results suggest that the metabotropic glutamate receptor agonist DHPG activates casein kinase I (CK1) epsilon via Ca(2+)-dependent stimulation of calcineurin and subsequent dephosphorylation of inhibitory C-terminal autophosphorylation sites.
the inability of PER3 to support circadian clock function results in part from lack of direct and stable interaction with casein kinase Iepsilon (CKIepsilon)
casein kinase I epsilon activity is regulated by Wnt signaling
Results suggest that casein kinase Iepsilon functions as a molecular switch to direct Dishevelled (Dvl) from the c-Jun N-terminal kinase pathway to the beta-catenin pathway, possibly by altering the conformation of the C terminus of Dvl.
Casein kinase 1epsilon activates minus-end-directed transport of membrane organelles along microtubules. CK1epsilon functions downstream of protein phosphatase PP2A in the pigment aggregation signaling pathway.
results demonstrate that Bride of Doubletime (BDBT) interacts with doubletime(DBT)in a manner requiring the DBT nuclear localization signal for nuclear localization and that the interaction is required to produce a fully functional circadian complex
we show that spag knock-down or reduced Dbt activity in circadian cells leads to longer circadian periods and expression of activated initiator caspase only during the middle of the day.
Responses of the clock to light via the regulated translation of DBT.
Data show that the HSP-90 cochaperone spaghetti protein (SPAG) antagonizes casein kinase I epsilon DBT autophosphorylation in S2 cells
Data demonstrate that overall reduction of DBT causes long and arrhythmic behavior revealing an unexpected role in promoting synchrony of the circadian clock network.
kinetics of PER degradation with DBT(S) in cell culture resembles that with wild-type DBT and posits that, in flies DBT(S) likely does not modulate the clock by simply affecting PER degradation kinetics
The introduction of CKI-epsilon point mutation L39Q, found in human breast cancer, into the fly homolog dco causes an overgrowth phenotype in imaginal disc tissue. Adding S101R, modifies the mutant phenotype so that the affected tissue disintegrates.
Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime
expression of DBT in Drosophila S2 cells produced a CKI-7-sensitive kinase activity which was reduced by both the dbt(S) and dbt(L) mutations of circadian rhythm
doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity
Dco coordinates tissue size by stimulating cell division/growth and blocking apoptosis via activation of DIAP1 expression.
This first analysis of adult flies with a virtual lack of DBT activity demonstrates that DBT's kinase activity is necessary for normal circadian rhythms and that a general reduction of DBT kinase activity does not produce short periods.
human casein kinase 1 epsilon cannot replace the activity of dbt in flies despite the high degree of similarity in primary sequence and kinase function
a key step in controlling the speed of the clock is phosphorylation of an N-terminal Ser (S47) by DBT, which collaborates with other nearby phosphorylated residues to generate a high-affinity atypical SLIMB-binding site on PER.
heterozygous mutations of this gene, which encodes the major catalytic subunit of PKA (cAMP-dependent kinase), delayed AMI onset by more than 2-fold without affecting lifespan and memory at young age.(review)
Data indicate that several DBT-directed phosphorylations regulate PER activity in an integrated fashion.
The results demonstrate a high degree of evolutionary conservation of fly and vertebrate CKIdelta and of the functions affected by their period-shortening mutations.
DBT plays a novel noncatalytic role in recruiting additional kinases that phosphorylate CLK, thereby repressing transcription
The absence of dbt expression in the follicular cells of previtellogenic egg is related to cytoplasmic expression of PER.
Mutation of ck1alpha or -epsilon or sgg/gsk3beta in wing imaginal discs results in the accumulation of dMyc protein, suggesting a physiological role for these kinases in vivo.
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.
, casein kinase I isoform epsilon
, casein kinase 1 epsilon
, discs overgrown
, casein kinase I, epsilon
, CKI, epsilon
, KC1 epsilon
, casein kinase I epsilon
, casein kinase 1, epsilon
, casein kinase I isoform epsilon-like
, CG2048 gene product from transcript CG2048-RD
, Protein double-time
, casein kinase 1
, casein kinase iepsilon
, disc overgrown
, double time