Browse our anti-desert Hedgehog (DHH) Antibodies

Human desert Hedgehog (DHH) interaction partners

1. Study describes two patients diagnosed with gonadal dysgenesis (GD), both harboring novel DHH compound heterozygous mutations p.[Tyr176*];[Asn337Lysfs*24] and p.[Tyr176*];[Glu212Lys]. While p.(Glu212Lys) retained 50% of its activity and led to a partially abolished DHH auto-processing, p.(Asn337Lysfs*24) resulted in a complete absence of auto-proteolysis.

2. Identify Dhh (desert hedgehog) as a downstream effector of Klf2, whose expression in endothelial cells is upregulated by shear stress and decreased by inflammatory cytokines.

3. Whole-exome sequencing revealed a homozygous variant in DHH leading to the p.Trp173Cys substitution. The relevant Trp residue is conserved, and its alteration was predicted to be deleterious. Molecular dynamics simulations showed that the mutation increases the conformational flexibility of the protein

4. Single nucleotide polymorphism in the DHH gene is associated with bipolar disorder.

5. Mutations in DHH play a role in 46,XY gonadal dysgenesis and are associated with seminoma formation and a neuropathy with minifascicle formation.

6. Findings are unprecedented and indicate that the DHH-RHEBL1 fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3-GLIS2-positive childhood AML.

7. Mutations in DHH are associated with 46,XY pure gonadal dysgenesis and mixed gonadal dysgenesis.

8. This study demonistrated that Desert hedgehog links transcription factor Sox10 to peripheral nerve development.

9. Studies indicate that pathways of Hedgehog (Hh), Wnt and Notch, which regulate development during embryonic life and somatic stem cells (SCs) in the adult organism, can be reactivated in malignancies and support tumor-initiating cells (TIC) scompartment.

10. Two cases have been described in Indian patients with 46,XY complete gonadal dysgenesis that could be attributable to mutations in the Desert hedgehog (DHH) gene leading to non-functional DHH protein.

11. We found no significant correlation between the expression of SOX9 and desert hedgehog, and neither SOX9 nor desert hedgehog expression was correlated to the histoprognostic grade in sarcomas.

12. These data demonstrate that DHH is a key molecule in both male gonadal differentiation and perineurial formation in peripheral nerves

13. Importance of DHH in mammalian male sexual differentiation, providing extended evidence that DHH constitutes a key gene in gonadal differentiation

14. its signal transduction regulates tumor development. (review)

15. Hh signaling is important in the pathogenesis of B-CLL and, hence, may be a potential therapeutic target

Zebrafish desert Hedgehog (DHH) interaction partners

1. characterized two new members of the Hedgehog (Hh) family in zebrafish, ihha and dhh, encoding for orthologues of the tetrapod Indian Hedgehog (Ihh) and Desert Hedgehog (Dhh) genes, respectively

Mouse (Murine) desert Hedgehog (DHH) interaction partners

1. Identify Dhh (desert hedgehog) as a downstream effector of Klf2, whose expression in endothelial cells is upregulated by shear stress and decreased by inflammatory cytokines.

2. the critical role of Dhh in maintaining blood nerve barrier integrity and demonstrates for the first time that endothelial dysfunction is sufficient to induce neuropathy

3. In organogenesis of the ovary, production of Dhh/Ihh in granulosa cells requires growth differentiation factor 9 from the oocyte.

4. increased expression in cell bodies of cutaneous sensory nerves of dorsal root ganglia as compared with skin epithelia

5. The results demonstrate a pivotal role for dhh in maintof this study aining myelination. Furthermore, dhh signaling reveals a potential target for therapeutic intervention to prevent and treat demyelination of peripheral nerves in compression neuropathies

6. Hedgehog signaling is impaired in aged mice. Hegdehog-dependent regulation of angiogenesis and myogenesis involves distinct mechanisms.

7. Data indicate that the centrosomal protein DZIP1 interacts with GLI3 transcription factor in the cytoplasm and regulates Hedgehog signaling and ciliogenesis.

8. Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival.

9. Desert hedgehog-dependent transcription in T cells promotes T helper (Th)2 cell transcriptional programs and differentiation, exacerbating allergic disease.

10. During recovery of hematopoiesis after irradiation, and under conditions of stress-induced erythropoiesis, erythrocyte differentiation was accelerated in both spleen and bone marrow of Dhh-deficient mice compared with wild type.

11. The findings suggest that Sertoli cells coordinate Dhh-dependent spermatogenesis events via Ptc1 and Smo prior to the first meiotic division and in postmeiotic (haploid) cells, particularly during the first half of spermiogenesis.

12. Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis

13. transgenic skin developed lesions reminiscent of human basal cell carcinoma

14. Prominent role of hedgehog signaling in the communication between granulosa cells and developing theca cells.

15. A single identified glial signal, desert hedgehog, plays a critical role in controlling the integrity of peripheral nervous tissue, in line with its critical role in nerve sheath development.

16. results demonstrate a functional desert hedgehog(HH) pathway in the follicle and identify granulosa cells as at least one of the potential targets of HH signaling

17. combinatorial expression of the paracrine factor Dhh and nuclear transcription factor Sf1 is required for Leydig cell development

18. Inactivation of Nf1 in the glial lineage in vitro at embryonic day 12.5 + 1, but not earlier (neural crest) or later (mature Schwann cell), results in colony-forming cells capable of multilineage differentiation.