anti-Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) Antibodies

Protein Summary

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.

Alternative names and synonyms associated with Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A)

• protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A) antibody
• protein kinase, cAMP dependent regulatory, type I, alpha (Prkar1a) antibody
• protein kinase cAMP-dependent type 1 regulatory subunit alpha (Prkar1a) antibody
• protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a (prkar1aa) antibody
• cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene (LOC707275) antibody
• Show all gene names
• protein kinase cAMP-dependent type I regulatory subunit alpha (Prkar1a) antibody
• protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog (prkar1a.S) antibody

• 1300018C22Rik antibody
• ACRDYS1 antibody
• ADOHR antibody
• CAR antibody
• CNC antibody
• Show all synonym aliases
• cnc1 antibody
• im:7047729 antibody
• pkr1 antibody
• ppnad1 antibody
• prkar1 antibody
• prkar1a antibody
• RIalpha antibody
• RIIA antibody
• Tse-1 antibody
• tse1 antibody
• zgc:92515 antibody

Protein level used designations for PRKAR1A

cAMP-dependent protein kinase regulatory subunit RIalpha , cAMP-dependent protein kinase type I-alpha regulatory chain , cAMP-dependent protein kinase type I-alpha regulatory subunit , protein kinase A type 1a regulatory subunit , tissue-specific extinguisher 1 , protein kinase, cAMP dependent regulatory, type 1, alpha , protein kinase, cAMP dependent regulatory, type I, alpha , cAMP-dependent protein kinase type I regulatory subunit , protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) , cAMP-dependent protein kinase, regulatory subunit alpha 1 , cAMP-dependent protein kinase regulatory subunit alpha 1 , cAMP-dependent protein kinase type I-alpha regulatory subunit-like , protein kinase, cAMP-dependent, regulatory subunit type I alpha S homeolog