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Human Annexin a1 Protein expressed in Wheat germ - ABIN1345166
Hamelin-Peyron, Vlaeminck-Guillem, Haïdous, Schwall, Poznanovi?, Gorius-Gallet, Michel, Larue, Guillotte, Ruffion, Choquet-Kastylevsky, Ataman-Önal: Prostate cancer biomarker annexin A3 detected in urines obtained following digital rectal examination presents antigenic variability. in Clinical biochemistry 2014
Human Annexin a1 Protein expressed in Wheat germ - ABIN1345170
Bhattacharjee, Ahamed, Pawlinski, Liu, Mackman, Ruf, Edgington: Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. in Circulation research 2008
this review details the therapeutic relevance of ANXA1 and its derived peptides in cardiovascular diseases since atherosclerosis stands out as a chronic inflammatory disease with impaired resolution and continuous leukocyte recruitment.
Our results indicated that ANXA1 may be a key mediator of hypoxia-related metastasis-associated processes in prostate cancer
Data indicate a regulatory circuit between ANXA1, NF-kB, c-myc (show MYC Proteins) and miR (show MLXIP Proteins)-196a which regulates breast cancer cell proliferation and tumor growth.
In colorectal cancer, miR (show MLXIP Proteins)-196a over-expression was negatively correlated with annexin A1 protein expression (r = -0.738, p < 0.001), and both were indicators of unfavorable prognosis in terms of poor differentiation, larger tumor size, and advanced clinical stage
The data of this study supported a potential role of ANXAl in AD by reducing Abeta (show APP Proteins) levels and decreasing neuroinflammation, suggesting a novel view that ANXAl may play a protective role in AD progression.
these data indicate that AnxA1 is actively expressed during L. braziliensis infection.
Data, including data from studies using knockout mice, suggest cAMP-elevating agents increase levels of ANXA1; this is involved in role of cAMP in resolving acute inflammation (here, ability of cAMP-elevating agents to treat LPS (show IRF6 Proteins)-induced neutrophilic pleurisy). These results reinforce hypothesis that ANXA1 acts in multiple cell types (neutrophils, macrophages) and at multiple levels to promote resolution of inflammation.
Circulating IgG antibodies to ANXA1 could be used as a biomarker for early diagnosis of non-small cell lung carcinoma.
Down-regulation of Annexin A1 in nasopharyngeal carcinoma may lead to the overexpression of S100A9 (show S100A9 Proteins)/Vimentin (show VIM Proteins), which may increase the possibility of the invasion ability of NPC (show NPC1 Proteins) cells by adjusting the function of cytoskeleton proteins.
ANXA1 is down-regulated and differentially expressed within the SCD (show SCD Proteins) genotypes
Data suggest amino acid substitution in ANXA1 (S27E; S27A (show RPS27A Proteins)) at site of post-translational phosphorylation affects protein stability, core domain calcium binding affinity, core domain/N-terminal domain structures, and N-terminal domain orientation.
annexin I is regulated by an anti-apoptotic Bcl-2 (show BCL2 Proteins) protein in Tumor Necrosis Factor-alpha (show TNF Proteins)-induced renal apoptotic events
Calves that later developed pneumonia had significantly lower levels of annexin A1 and annexin A2 (show ANXA2 Proteins), which are potential biomarkers of increased susceptibility to pneumonia in recently weaned and transported feedlot cattle.
Ubiquitination of annexin A1 may play an important role in mutagenesis, an initial step of cell transformation.
Because annexins I and II are abundant and have functions important to the maintenance of placentation, the down-regulation of the annexin genes in the cultured NT (nuclear transfer)trophectoderm may be related to the frequent failures of NT pregnancies.
ANXA1 can be phosphorylated by PKC and is subsequently translocated to the nucleus of BV-2 microglial cells after oxygen glucose deprivation/reoxygenation, resulting in the induction of pro-inflammatory cytokines.
Our data indicate that hepatic overexpression of ANX1 and ANX2 (show ANXA2 Proteins) inhibits APAP-induced expansion of liver injury
The present findings shed light on the role of GILZ (show TSC22D3 Proteins) in the mechanism of induction of Anxa1 by GCs (show UGCG Proteins). As Anxa1 is an important protein for the resolution of inflammatory response, GILZ (show TSC22D3 Proteins) may represent a new pharmacologic target for treatment of inflammatory diseases.
Data, including data from studies using knockout mice, suggest cAMP-elevating agents increase levels of AnxA1; this is involved in role of cAMP in resolving acute inflammation (here, ability of cAMP-elevating agents to treat LPS (show TLR4 Proteins)-induced neutrophilic pleurisy). These results reinforce hypothesis that AnxA1 acts in multiple cell types (neutrophils, macrophages) and at multiple levels to promote resolution of inflammation.
confirmed the ability of Plg (show PLG Proteins)/Pla to both promote efferocytosis and override the prosurvival effect of LPS (show TLR4 Proteins) via annexin A1.
this study shows that AnxA1 plays a crucial role in the context of acute gouty inflammation by promoting timely resolution of inflammation
Suggest protective role for Annexin A1 in arterial neointima formation in atherosclerosis-prone mice.
ANXA1 restores Abeta42-induced blood brain barrier disruption through inhibition of RhoA (show RHOA Proteins)-ROCK signaling pathway
Here, we provide a new anti-inflammation mechanism about ANXA1 secreted from injured IECs, where ANXA1 can stimulate the expression of NKG2A (show KLRC1 Proteins) in NK cells that affect the recruitment and activity of neutrophils necessary for pathology of colitis.
Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
, ANX Ia
, annexin 1a
, lipocortin 1
, Annexin A1
, annexin A1-like
, annexin I (lipocortin I)
, calpactin II
, lipocortin I
, phospholipase A2 inhibitory protein
, annexin I
, Annexin 1 (p35) (Lipocortin 1)
, calcium-dependent membrane binding protein annexin I