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Full name:: Corticotropin Releasing Hormone Receptor 1 Proteins (CRHR1)

On www.antibodies-online.com are 9 Corticotropin Releasing Hormone Receptor 1 (CRHR1) Proteins from 4 different suppliers available. Additionally we are shipping CRHR1 Antibodies (173) and CRHR1 Kits (24) and many more products for this protein. A total of 214 CRHR1 products are currently listed.

Synonyms:: CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRH-R1h, Crhr, CRHR1, crhr1-A, CRHR1-IT1-CRHR1, CRHR1f, CRHR1L, MGC57346-CRHR1

list all proteins	Gene Name	GeneID	UniProt
	CRHR1	1394	P34998
	CRHR1	58959	P35353
	CRHR1	12921	P35347
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Human Corticotropin Releasing Hormone Receptor 1 (CRHR1) interaction partners

Significantly higher CRF1 and CRF2 receptor (show CRHR2 Proteins) levels after CNS sensitization were detected in the Hippocampus.
found no differences in genotype distributions between heroin-dependent subjects and controls. However, identified a prominent interaction of one variant of the CRHBP (show CRHBP Proteins) gene predicting the risk of heroin relapse in the chronically stressed subjects.
The large scale refinement of transmembrane helices of the CRFR1 homology model resulted in the significant improvement of its accuracy with respect to the crystal structure of CRFR1, especially in the binding site area.
Data suggest that corticotrophin-releasing hormone (CRH (show CRH Proteins)) is able to stimulate copeptin (show AVP Proteins) release in healthy controls suggesting direct interaction of CRH/CRH (show CRH Proteins)-receptor signaling and vasopressin (show AVP Proteins); these interactions appear to be altered in patients with pituitary disease; copeptin (show AVP Proteins) may be serum biomarker of altered CRH/CRH (show CRH Proteins)-receptor signaling in pituitary diseases.
The negative and positive inputs are integrated by hypoxic initiation and duration in CRHR1 transcription.
This study suggests that SNPs in the CRHR1 gene may influence BDNF (show BDNF Proteins) levels in crack cocaine addiction.
found an interaction between CRHR1 Single Nucleotide Polymorphisms and maternal depression, with the homozygous minor genotype acting as a protective factor against brooding in the presence of maternal depression.
The results reveal that specific CRHR1 polymorphisms moderate the effect of Early life stress on emotional empathy.
A significant increase in CRH (show CRH Proteins) and CRHR-1 expression was significantly correlated with psychological stress in vitiligo (show MITF Proteins).
The present study identified a potential role of CRHR1 hypomethylation - conferring increased CRHR1 expression - in panic disorder and a related dimensional intermediate phenotype.

Mouse (Murine) Corticotropin Releasing Hormone Receptor 1 (CRHR1) interaction partners

Expression of Crhr1 is decreased in the pituitary gland of corticotropin-releasing hormone (show CRH Proteins) knock-out mice exposed to repeat stress.
CRF-R1 expression levels were proportional to the severity of DSS (show PMP22 Proteins)-induced colitis. Activation of CRF-R1 aggravated inflammation, and inhibition of CRF-R1 ameliorates inflammation evaluated by the DAI (show ZBP1 Proteins) and histological scores in the colon samples of the DSS (show PMP22 Proteins)-treated mice.
report a sexually dimorphic expression of CRFR1 within the rostral portion of the anteroventral periventricular nucleus of the hypothalamus
These results revealed a prominent role for CRF1 signaling in mast cells as a positive modulator of stimuli-induced degranulation.
switch in G protein coupling for type 1 corticotropin-releasing factor (show CRH Proteins) receptors promotes excitability in epileptic brains
Study characterized the influences of early-life stress on the developmental trajectory of hippocampal pyramidal neurons, and highlighted the critical role of CRHR1 in modulating these negative outcomes evoked by early-life stress.
the beneficial effects of CRFR1 antagonism seen in transgenic mice may be mechanistically linked to the modulation of oxidative stress pathways
CRF plays a marked anxiogenic role at CRF1 receptors in the amygdala of mice exposed to the elevated plus maze.
found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
Excitability of genetically isolated CRF (show CRH Proteins)-receptive (CRFR1) neurons in the central nucleus of the amygdala (CeA (show CEA Proteins)) is potently enhanced by CRF (show CRH Proteins) and that CRFR1 signaling in the CeA (show CEA Proteins) is critical for discriminative fear

Cow (Bovine) Corticotropin Releasing Hormone Receptor 1 (CRHR1) interaction partners

These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 and CRHR2 and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
CRHR1 and CRHR2 (show CRHR2 Proteins) are expressed in the bovine adrenal gland.
results indicate that arginine vasopressin (show AVP Proteins) receptor V3 and corticotropin-releasing factor receptor 1 mRNAs are coordinately downregulated in the anterior pituitary during systemic inflammatory stress in cattle[AVP receptor V3 (show AVPR1B Proteins)]

Xenopus laevis Corticotropin Releasing Hormone Receptor 1 (CRHR1) interaction partners

CRF (show CRH Proteins) is expressed in tadpole tail, is up-regulated by environmental stressors, and is cytoprotective

Pig (Porcine) Corticotropin Releasing Hormone Receptor 1 (CRHR1) interaction partners

CRFr1 activation mediates intestinal mucosa barrier dysfunction and hypersecretion in early-weaned piglets, whereas CRFr2 (show CRHR2 Proteins) activation may be responsible for novel protective properties in the porcine intestine in response to early life stress.

Horse (Equine) Corticotropin Releasing Hormone Receptor 1 (CRHR1) interaction partners

The expression of UCN, CRHR1, CRHR2 and CRHBP by immunohistochemistry, Western blot and reverse transcription with the polymerase chain reaction (RT-PCR) in the horse thyroid gland, was investigated

Rhesus Monkey Corticotropin Releasing Hormone Receptor 1 (CRHR1) interaction partners

The results of this study suggested that variation in CRHR1 may influence brain function before any childhood adversity and may be a diathesis for the interaction between CRHR1 genotypes and childhood trauma reported to affect human psychopathology

Guinea Pig Corticotropin Releasing Hormone Receptor 1 (CRHR1) interaction partners

Results suggest that blockade of CRF1 and CRF2 receptors in the basolateral and central nuclei of the amygdala reduces the duration of tonic immobility behavior associated with extreme threat situations, probably due to decreased fear and/or anxiety.

CRHR1 Protein Profile

Protein Summary

This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene.

Alternative names and synonyms associated with CRHR1

corticotropin releasing hormone receptor 1 (CRHR1)
corticotropin releasing hormone receptor 1 (Crhr1)
corticotropin releasing hormone receptor 1, gene 2 S homeolog (crhr1.2.S)
corticotropin-releasing factor receptor 1 (LOC610380)
corticotropin-releasing factor receptor 1 (LOC100065598)
LINC02210-CRHR1 readthrough (LINC02210-CRHR1)
corticotropin releasing hormone receptor 1 (crhr1)

CRF-R protein
CRF-R-1 protein
CRF-R1 protein
CRF1 protein
CRFR-1 protein
CRFR1 protein
CRH-R-1 protein
CRH-R1 protein
CRH-R1h protein
Crhr protein
CRHR1 protein
crhr1-A protein
CRHR1-IT1-CRHR1 protein
CRHR1f protein
CRHR1L protein
MGC57346-CRHR1 protein

Protein level used designations for CRHR1

, , , , , , , , , , , , , , , , , , , , , , , , corticotropin releasing hormone receptor variant 1e corticotropin releasing hormone receptor variant 1g corticotropin-releasing factor receptor 1 corticotropin-releasing factor type 1 receptor corticotropin-releasing hormone receptor 1 seven transmembrane helix receptor CRF-R-1 CRF-R1 CRFR-1 CRH-R-1 CRH-R1 corticotropin releasing factor receptor type 1 CRF-R CRF1 CRH-R 1 corticotrophin releasing hormone receptor 1 corticotropin releasing hormone 1 CRF 1 receptor CRF-R1alpha corticotropin releasing hormone receptor type I corticotropin releasing hormone receptor 1 corticotrophin-releasing factor type 1 alpha receptor CRHR1-IT1-CRHR1 protein CRHR1-IT1-CRHR1 readthrough Corticotropin-releasing hormone receptor 1

GENE ID	SPECIES
1394	Homo sapiens
443025	Ovis aries
58959	Rattus norvegicus
12921	Mus musculus
281716	Bos taurus
373580	Xenopus laevis
374218	Gallus gallus
397426	Sus scrofa
468283	Pan troglodytes
610380	Canis lupus familiaris
723971	Felis catus
100065598	Equus caballus
100302436	Oryctolagus cuniculus
574095	Macaca mulatta
104909134	Homo sapiens
100729987	Cavia porcellus
567940	Danio rerio

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