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This study suggests that SNPs in the CRHR1 gene may influence BDNF (show BDNF Proteins) levels in crack cocaine addiction.
found an interaction between CRHR1 Single Nucleotide Polymorphisms and maternal depression, with the homozygous minor genotype acting as a protective factor against brooding in the presence of maternal depression.
The results reveal that specific CRHR1 polymorphisms moderate the effect of Early life stress on emotional empathy.
A significant increase in CRH (show CRH Proteins) and CRHR-1 expression was significantly correlated with psychological stress in vitiligo (show MITF Proteins).
The present study identified a potential role of CRHR1 hypomethylation - conferring increased CRHR1 expression - in panic disorder and a related dimensional intermediate phenotype.
CRH-R1 contributes to the dysregulated stress responsiveness in IBS.
These results revealed a prominent role for CRF1 signaling in mast cells as a positive modulator of stimuli-induced degranulation.
This review showed a significant genetic association in most studies in CRHR1 genes with a high rate of attempted suicide.
Our results strengthen the evidence for the role of CRHR1 single nucleotide polymorphisms in major depressive disorder susceptibility and suggest that their effects may be modulated by sex and smoking status.
results confirm the role of TPH1 (show TPH1 Proteins), TPH2 (show TDO2 Proteins), 5HT2A, CRHR1 and ACP1 (show ACP1 Proteins) variants in the risk of suicidal behavior.
switch in G protein coupling for type 1 corticotropin-releasing factor (show CRH Proteins) receptors promotes excitability in epileptic brains
Study characterized the influences of early-life stress on the developmental trajectory of hippocampal pyramidal neurons, and highlighted the critical role of CRHR1 in modulating these negative outcomes evoked by early-life stress.
the beneficial effects of CRFR1 antagonism seen in transgenic mice may be mechanistically linked to the modulation of oxidative stress pathways
CRF plays a marked anxiogenic role at CRF1 receptors in the amygdala of mice exposed to the elevated plus maze.
found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic-pituitary-adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
Excitability of genetically isolated CRF (show CRH Proteins)-receptive (CRFR1) neurons in the central nucleus of the amygdala (CeA (show CEA Proteins)) is potently enhanced by CRF (show CRH Proteins) and that CRFR1 signaling in the CeA (show CEA Proteins) is critical for discriminative fear
Study demonstrated that CRF1 receptor-deficiency prolongs whereas CRF2 receptor (show CRHR2 Proteins)-deficiency shortens the duration of recognition memory deficits induced by morphine discontinuation, unraveling opposite roles for the two known CRF (show CRH Proteins) receptor subtypes in cognitive dysfunction associated with opiate withdrawal.
CRFR1, in a subset of AgRP (show AGRP Proteins) neurons, plays a regulatory role that enables appropriate sympathetic nervous system activation and consequently protects the organism from hypothermia and hypoglycemia.
the cyclic AMP (show TMPRSS5 Proteins) (cAMP) response of CRHR1 in physiologically relevant scenarios engages separate cAMP sources, involving the atypical soluble adenylyl cyclase (sAC (show ADCY10 Proteins)) in addition to transmembrane adenylyl cyclases (tmACs).
These results suggest that a regulatory system exists in the bovine thyroid gland based on UCN, CRHR1 and CRHR2 and that UCN plays a role in the regulation of thyroid physiological functions through an autocrine/paracrine mechanism.
CRHR1 and CRHR2 (show CRHR2 Proteins) are expressed in the bovine adrenal gland.
results indicate that arginine vasopressin (show AVP Proteins) receptor V3 and corticotropin-releasing factor receptor 1 mRNAs are coordinately downregulated in the anterior pituitary during systemic inflammatory stress in cattle[AVP receptor V3 (show AVPR1B Proteins)]
CRF (show CRH Proteins) is expressed in tadpole tail, is up-regulated by environmental stressors, and is cytoprotective
CRFr1 activation mediates intestinal mucosa barrier dysfunction and hypersecretion in early-weaned piglets, whereas CRFr2 (show CRHR2 Proteins) activation may be responsible for novel protective properties in the porcine intestine in response to early life stress.
The expression of UCN, CRHR1, CRHR2 and CRHBP by immunohistochemistry, Western blot and reverse transcription with the polymerase chain reaction (RT-PCR) in the horse thyroid gland, was investigated
The results of this study suggested that variation in CRHR1 may influence brain function before any childhood adversity and may be a diathesis for the interaction between CRHR1 genotypes and childhood trauma reported to affect human psychopathology
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346.
corticotropin releasing hormone receptor variant 1e
, corticotropin releasing hormone receptor variant 1g
, corticotropin-releasing factor receptor 1
, corticotropin-releasing factor type 1 receptor
, corticotropin-releasing hormone receptor 1
, seven transmembrane helix receptor
, corticotropin releasing factor receptor type 1
, CRH-R 1
, corticotrophin releasing hormone receptor 1
, corticotropin releasing hormone 1
, CRF 1 receptor
, corticotropin releasing hormone receptor type I
, corticotropin releasing hormone receptor 1
, corticotrophin-releasing factor type 1 alpha receptor