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Mouse (Murine) Monoclonal ITGA4 Primary Antibody for BR, FACS - ABIN2689307 : Romanic, Graesser, Baron, Visintin, Janeway, Madri: T cell adhesion to endothelial cells and extracellular matrix is modulated upon transendothelial cell migration. in Laboratory investigation; a journal of technical methods and pathology 1997 (PubMed) Show all 11 Pubmed References
Mouse (Murine) Monoclonal ITGA4 Primary Antibody for FACS - ABIN2689312 : Andrew, Berlin, Honda, Yoshino, Hamann, Holzmann, Kilshaw, Butcher: Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation. in Journal of immunology (Baltimore, Md. : 1950) 1994 (PubMed) Show all 7 Pubmed References
Mouse (Murine) Monoclonal ITGA4 Primary Antibody for BR, FACS - ABIN1176851 : Chisholm, Williams, Lobb: Monoclonal antibodies to the integrin alpha-4 subunit inhibit the murine contact hypersensitivity response. in European journal of immunology 1993 (PubMed) Show all 5 Pubmed References
Baboon Monoclonal ITGA4 Primary Antibody for FACS - ABIN2689308 : Berlin, Berg, Briskin, Andrew, Kilshaw, Holzmann, Weissman, Hamann, Butcher: Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. in Cell 1993 (PubMed) Show all 5 Pubmed References
Human Monoclonal ITGA4 Primary Antibody for CyTOF, FACS - ABIN4900793 : Zhang, Fu, Hu, Dong, Song, Song: C6-ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCζ tumor-suppressive activities and regulating integrin affinity modulation. in Scientific reports 2015 (PubMed) Show all 4 Pubmed References
Human Monoclonal ITGA4 Primary Antibody for CyTOF, FACS - ABIN4900794 : van Grevenstein, Hofland, van Rossen, van Koetsveld, Jeekel, van Eijck: Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers. in Digestive diseases and sciences 2007 (PubMed) Show all 4 Pubmed References
Human Monoclonal ITGA4 Primary Antibody for Func, FACS - ABIN610119 : Chang, Peng, Fu: Interleukin-4 mediates cell growth inhibition through activation of Stat1. in The Journal of biological chemistry 2000 (PubMed) Show all 3 Pubmed References
Human Monoclonal ITGA4 Primary Antibody for Func, FACS - ABIN610120 : Fu, Zhang: Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter. in Cell 1993 (PubMed) Show all 3 Pubmed References
Human Polyclonal ITGA4 Primary Antibody for IHC (p) - ABIN2480755 : Lin, Castro: Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents. in Current opinion in chemical biology 1998 (PubMed) Show all 4 Pubmed References
Baboon Monoclonal ITGA4 Primary Antibody for FACS - ABIN2689306 : Hemler, Huang, Takada, Schwarz, Strominger, Clabby: Characterization of the cell surface heterodimer VLA-4 and related peptides. in The Journal of biological chemistry 1987 (PubMed) Show all 3 Pubmed References
study analyzes for the first time the expressions of epithelial-mesenchymal transition marker proteins - periostin (show POSTN Antibodies), integrin alpha4, fibronectin (show FN1 Antibodies) - in metastatic castration-resistant prostate cancer
ITGalpha4beta1 and TLR4 (show TLR4 Antibodies) have roles in inducing fibrotic gene expression in response to fibronectin's EDA (show EDA Antibodies) domain
ITGA4 and PLCG1 (show PLCG1 Antibodies) are regulated by miR (show MLXIP Antibodies)-30b in coronary artery endothelial cells from coronary atherosclerosis clinical samples.
alpha-Integrin expression and function modulates presentation of cell surface calreticulin (show CALR Antibodies).
AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.
sPLA2-IIA (show PLA2G2A Antibodies) activates Integrin alphaVbeta3 (show ITGAV Antibodies) and Integrin alpha4beta1 in an allosteric manner. (Review)
Our results suggest that the analysis of alpha4beta7 integrin expression on circulating lymphocytes cannot be considered a reliable test for gastrointestinal involvement in CVID (show TNFRSF13B Antibodies) patients
In colon cancer samples, there was a positive correlation between the expression of integrin alpha4 and VEGF-C (show VEGFC Antibodies). Integrin alpha4 and VEGF-C (show VEGFC Antibodies) were significantly associated with the clinicopathological parameters (LMVD, Duke's stage, and lymph node metastasis). patients with high integrin alpha4 or VEGF-C (show VEGFC Antibodies) expression had significantly shorter overall survival and tumor-free survival time.
Macrophage tissue factor (show F3 Antibodies) prothrombotic activity is regulated by integrin-alpha4/arf6 (show ARF6 Antibodies) trafficking.
gut (show GUSB Antibodies)-homing alpha4beta7 CD4 (show CD4 Antibodies)(+) T cells and their functional subsets were profoundly depleted during acute HIV-1 infection.
integrin alpha4beta1 mediates the inhibitory effect of oncofetal Fibronectin (show FN1 Antibodies) both in vitro as well as in vivo.
Here we delineated an inflammation-driven inhibitory mechanism of beige (show LYST Antibodies) adipogenesis in obesity that required direct adhesive interactions between macrophages and adipocytes mediated by the integrin alpha4 and its counter-receptor VCAM-1 (show VCAM1 Antibodies), respectively; expression of the latter was upregulated in obesity.
uncovered the importance of Itga4 for the generation of regulatory B cells in peripheral immune organs and their control of pathogenic T cell response and CNS pathology
this study shows that alpha4beta1 integrin mediates memory CD8 (show CD8A Antibodies)+ T cells accumulation in salivary glands after infection with lymphocytic choriomeningitis virus
The results uncovered a previously unknown role of integrin a4b7-MAdCAM-1 (show MADCAM1 Antibodies) interactions as drivers of colitis by directing inflammatory monocytes into the colon.
These results suggest that Tie2 (show TEK Antibodies) signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1 (show VCAM1 Antibodies).
ITGA4 expression enhances metastasis in MYCN (show MYCN Antibodies) low neuroblastoma (show ARHGEF16 Antibodies).
CD49d-high-expressing Th1 (show HAND1 Antibodies) memory phenotype CD4 (show CD4 Antibodies)+ T cells with enhanced B cell helper activity develop early in the peritoneal cavity.
Administration of a novel recombinant antibody against alpha4beta7 gut (show GUSB Antibodies)-homing integrin during acute lentiviral infection prevents mobilization of cell lineages of the innate immune system and protects the gut (show GUSB Antibodies) tissues from acute lentiviral infection.
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
269C wild type , CD49 antigen-like family member D , VLA-4 subunit alpha , antigen CD49D, alpha-4 subunit of VLA-4 receptor , integrin alpha 4 , integrin alpha-4 , integrin alpha-4 subunit , integrin alpha-IV , very late activation protein 4 receptor, alpha 4 subunit , LPAM subunit alpha , VLA-4 receptor, alpha 4 subunit , lymphocyte Peyer patch adhesion molecules subunit alpha