Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

ITGA4 antibody (Integrin alpha 4) (FITC) Primary Antibody

ITGA4 Reactivity: Human, Cat, Cow, Dog, Horse, Non-Human Primate, Sheep FACS, Func, IHC (fro) Host: Mouse Monoclonal 9F10 FITC
Catalog No. ABIN6579824
$455.40
Plus shipping costs $45.00
100 tests
local_shipping Shipping to: United States
Delivery in 5 to 7 Business Days
  • Target
    ITGA4
    Reactivity
    • 163
    • 138
    • 44
    • 19
    • 10
    • 8
    • 8
    • 8
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Cat, Cow, Dog, Horse, Non-Human Primate, Sheep
    Host
    • 88
    • 84
    • 66
    • 1
    • 1
    Mouse
    Clonality
    • 160
    • 80
    • 1
    Monoclonal
    Conjugate
    • 107
    • 28
    • 24
    • 20
    • 9
    • 9
    • 7
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITGA4 antibody is conjugated to FITC
    Application
    • 165
    • 54
    • 51
    • 47
    • 39
    • 24
    • 23
    • 13
    • 12
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    The mouse monoclonal antibody 9F10 recognizes CD49d (alpha 4 integrin), a 145-180 kDa type I transmembrane glycoprotein expressed on B and T cells, monocytes, eosinophils, basophils, NK cells, and dendritic cells, but not platelets.
    HLDA V, WS Code S215
    Cross-Reactivity (Details)
    Human, Non-Human Primates, Bovine, Canine (Dog), Equine (Horse), Feline (Cat), Sheep
    Clone
    9F10
    Isotype
    IgG1
  • Application Notes
    The reagent is designed for Flow Cytometry analysis of human blood cells using 4 μ,l reagent / 100 μ,l of whole blood or 10^6 cells in a suspension.The content of a vial (0.4 ml) is sufficient for 100 tests.
    Comment

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Buffer
    The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
  • Target
    ITGA4
    Alternative Name
    CD49d / Integrin alpha 4 (ITGA4 Antibody Abstract)
    Synonyms
    CD49D, IA4, LOC100219853, integrin subunit alpha 4, integrin alpha 4, integrin subunit alpha 4 S homeolog, ITGA4, Itga4, itga4.S
    Background
    CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.
    Pathways
    Integrin Complex
You are here:
help Support