Browse our anti-GRF2 (RAPGEF1) Antibodies

Human Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) interaction partners

1. our studies uncover novel mechanisms by which C3G controls key aspects of tumorigenesis.

2. C3G/RAP1 activity is involved in the metastatic spread of epithelial ovarian cancer.

3. C3G plays an important role in platelet clotting through a mechanism involving its GEF (show SLC2A4RG Antibodies) activity and suggest that it might be also involved in neutrophil development.

4. The possibility of cellular phospho-C3G (pC3G) being a substrate of the intracellular T-cell protein tyrosine phosphatase TC-PTP (show PTPN2 Antibodies) (PTPN2 (show PTPN2 Antibodies)) using the human neuroblastoma (show ARHGEF16 Antibodies) cell line, was studied.

5. Lyn (show LYN Antibodies) controls spatial activation of Rap1 (show RABGEF1 Antibodies) by recruiting the CrkL (show CRKL Antibodies)-C3G protein complex to the leading edge

6. found somatic demethylation of a relaxed-criterion CpG island (CGI-B) located in the first intron of RAPGEF1 in 40% of colon cancers and 8% of gastric cancers relative to their matching normal tissues that were always methylated

7. Data demonstrated that the polymorphism in TP53 (show TP53 Antibodies) (rs1042522) was associated with type 2 diabetes, and that potential interaction of TP53 (show TP53 Antibodies) (rs1042522) and RAPGEF1 (rs11243444), or NRF1 (show NFE2L1 Antibodies) (rs1882095) increased the risk of type 2 diabetes.

8. significant positive correlation between layers II and IV of the dorso-lateral prefrontal cortex in the percentage of MR-GEF expressing neurons in individuals with bipolar disorder

9. C3G overexpression induces neurite-like extensions in MDA-MB-231 and BT549 breast carcinoma cells and not in a variety of other cancer cell lines examined.

10. C3G as a novel target of c-Abl

Mouse (Murine) Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) interaction partners

1. C3G is required in cortical neurons for both the specification of an axon and the initiation of radial migration by forming a leading process.

2. results provide evidence that C3G plays an important role in myogenic differentiation by coordinating cell cycle exit, actin dynamics and survival signaling.

3. C3G regulates sympathetic preganglionic neuron migration by acting downstream in the reelin (show RELN Antibodies) signaling pathway.

4. Data indicate that chemical rescue of c-Src provided a tool to dissect the spatiotemporal mechanism of activation of the Rap1 guanine exchange factor, C3G, one of the identified potential c-Src substrates that plays a role in focal adhesion signaling.

5. GEF and Dlx1/2 form part of a common signalling pathway during GABAergic neuronal development.

6. Guanine nucleotide releasing factor 2 (show RASGRF2 Antibodies) is a negative regulator of Mitogen-Activated Protein Kinase 14 (show MAPK14 Antibodies) in mouse embryonic fibroblasts and can promote cell survival or cell death depending on the stimuli.

7. Targeted disruption of Ras-Grf2 (show RASGRF2 Antibodies) shows its dispensability for mouse growth and development.

8. These results show that C3G is required for (1) vascular myogenesis, (2) the formation of paxillin (show PXN Antibodies)- and integrin beta1-positive, but not integrin beta3-positive, cell adhesions and (3) normal response to PDGF (show PDGFA Antibodies), necessary for vascular myogenesis.

9. roles of C3G-Rap1 signaling pathway in various biological processes

10. Our results show that the size of the cortical neural precursor population is controlled by C3G-mediated inhibition of the Ras signalling pathway.

Pig (Porcine) Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1) interaction partners

1. the SSC5:60296617 SNP may affect teat number by regulating the interaction of EPS8 (show EPS8 Antibodies) and RAPGEF1 and, finally, affecting the mammogenesis of pigs