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Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN1305087
Farrar, Schreiber: The molecular cell biology of interferon-gamma and its receptor. in Annual review of immunology 1993
Show all 3 Pubmed References
Rat (Rattus) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN1305089
Gray, Goeddel: Cloning and expression of murine immune interferon cDNA. in Proceedings of the National Academy of Sciences of the United States of America 1983
Show all 2 Pubmed References
Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN803857
Shiraki, Ishibashi, Hiruma, Nishikawa, Ikeda: Candida albicans abrogates the expression of interferon-gamma-inducible protein-10 in human keratinocytes. in FEMS immunology and medical microbiology 2008
Show all 2 Pubmed References
Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN935524
POGO, BRAWERMAN, CHARGAFF: New ribonucleic acid species associated wihin the formation of the photosynthetic apparatus in Euglena gracilis. in Biochemistry 1970
Mouse (Murine) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN804259
Apte, Baz, Groves, Kelso, Kienzle: Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cells. in Proceedings of the National Academy of Sciences of the United States of America 2008
Mouse (Murine) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN413386
Kajiwara, Schiff, Voloudakis, Gama Sosa, Elder, Bozdagi, Buxbaum: A critical role for human caspase-4 in endotoxin sensitivity. in Journal of immunology (Baltimore, Md. : 1950) 2014
Human IFNG Protein expressed in HEK-293 Cells - ABIN2181249
Derynck, Leung, Gray, Goeddel: Human interferon gamma is encoded by a single class of mRNA. in Nucleic acids research 1982
Show all 3 Pubmed References
IL-15 (show IL15 Proteins) induces the activation and survival of effector immune cells that are necessary for its antitumoral activity; but, long-term exposure to IL-15 (show IL15 Proteins) is associated with the development of important side effects mainly mediated by IFN-gamma-producing T-cells
Arid5a deficiency resulted in decreased levels of IFN-gamma under Th1 cell conditions, in which T-box expressed in T cells (T-bet) mRNA expression was inhibited.
these findings highlight critical roles for IFN-gamma and IL-27 (show IL27 Proteins) in the mechanism of respiratory syncytial virus-induced exacerbation
MyD88 (show MYD88 Proteins) signaling in myeloid and dendritic cells is dispensable for IFN-gamma-dependent control of type A F. tularensis infection.
spleen-derived IFN-gamma induces generation of PD-L1 (show CD274 Proteins)(+)-suppressive neutrophils.
These results suggest that IL-17A (show IL17A Proteins) plays an important role in host survival against Toxoplasma gondii infection by protecting the host from an anaphylactic reaction via the downregulation of Toxoplasma gondii HSP70 (show HSP70 Proteins) and IFN-gamma production.
Stat3 (show STAT3 Proteins) mediates the expression of iNOS (show NOS2 Proteins) to promote IFNgamma/TNFalpha (show TNF Proteins)-induced muscle atrophy.
NFAT5 (show NFAT5 Proteins) can modulate different T-cell responses depending on stress conditions and stimulatory context.
we identify interferon-gamma (IFN-gamma) as the key inflammatory mediator controlling sortilin-1 (show SORT1 Proteins) levels
this study shows that IFN-gamma induction by neutrophil-derived IL-17A (show IL17A Proteins) homodimer augments pulmonary antibacterial defense
Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 (show IL4 Proteins) ratio were significantly lower than those exposed to its low concentration.
Results showed that IFNG upregulated PD-L1 (show CD274 Proteins) expression in gastric cancer cells mainly through JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) pathway.
The findings suggest that not the IFN-gamma (+874) A/T but the IL-12 (show IL12A Proteins) (-1188) A/C polymorphism is correlated with subacute sclerosing panencephalitis (SSPE), and having an AA genotype or A allele decreases the risk of developing SSPE by 2.06- and 1.65-fold, respectively.
This review focuses on the immune modulatory functions of IFN-gamma in cancer.
Cytokines (IFNg and IL-4 (show IL4 Proteins)) estimation was done in the blood and NPA samples of cases and blood samples of controls.The mean levels of interleukin-4 (show IL4 Proteins) in controls (blood), and cases (NPA and blood) were 1280.77, 956.08 and 692.37 pg/ml, respectively (P<0.05).
Severe gastroenteritis and acute pancreatitis following rotavirus infection in children: The age-related failure of IFN-gamma.
Our observations suggested that IL-10 (show IL10 Proteins) -592 A/C, -1082 G/A, and IFN-gamma +874 T/A polymorphisms had a strong association with susceptibility to HCV infection. However, no significant association was observed between the cytokines (IL-10 (show IL10 Proteins) and IFN-gamma) genotypes profile and HCV-liver cirrhosis risk in the studied population, except for the high frequency of IFN-gamma +874 T allele in cirrhotic patients.
IFNgamma induced PPAR gamma coactivator-1 alpha (PGC-1alpha) positively regulated RIG-I; with PRMT-1 and G9a affecting PGC-1alpha in a counter-regulatory manner.
Results showed that plasma and mRNA levels of IL-2 (show IL2 Proteins), IFN-gamma, IL-4 (show IL4 Proteins), and IL-17A (show IL17A Proteins) in primary immune thrombocytopenia patients did not change significantly after TPO (show THPO Proteins)-RA treatment, whereas TGF-beta1 (show TGFB1 Proteins) levels increased remarkably.
These findings demonstrate how IFNgamma induced CK2 (show CSNK2A1 Proteins) regulates RIG-I (show DDX58 Proteins) to drive a complex program of metabolic adaptation and redox homeostasis, crucial for determining glioma cell fate.
Data indicate that dysregulated IFN-gamma secretion by NK cells contributed to a significant defect in STAT1 (show STAT1 Proteins) in patients with advanced melanoma in response to IL-2 (show IL2 Proteins) stimulation.
The regulatory effect of IFN-gamma on CYP3A29 expression is mediated via PXR (show NR1I2 Proteins).
Translational control of IL-18 (show IL18 Proteins) expression by its 5'-UTR limits production of IL-18 (show IL18 Proteins), resulting in restricted expression of mRNA and protein IFN-gamma in this model of crescentic glomerulonephritis(GN). Might amplify CD8 (show CD8A Proteins)+-mediated macrophage-dependent GN.
selective changes in immature crypt cells induced by IFN-gamma bound to extracellular matrix could contribute to inappropriate responsiveness to commensal bacteria in inflammatory bowel diseases
A functional single nucleotide polymorphism is reported in the coding region of IFN-gamma cDNA that markedly reduces antiviral activity of the IFN-gamma protein.
The expression of IFN-gamma in recombiannt Lactococcus lactis as a tool for investigating downregulation of allergic predisposition of pigs to experimental food allergy is reported.
The expression of multiple toll (show TLR4 Proteins)-like receptors, interferon-gamma, and interleukin-12 (IL-12 (show IL12A Proteins)) in cattle with low and high proviral loads of bovine leukemia virus are reported.
Diet-driven interferon-gamma enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy.
Data suggest that luteolytic factors (such as IFNG, tumor necrosis factor alpha (show TNF Proteins), and PGF2a) control expression of MMP1 (show MMP1 Proteins), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These findings indicate that IFN-gamma production correlates negatively and the production of antibodies against N. caninum is uncorrelated with plasma pregnancy-associated glycoproteins levels.
These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma occurring after parturition and an increase in IL-4 (show IL4 Proteins) production before calving.
Genetic characterization of IFNG gene was done in resistant and susceptible animals of Sahiwal cattle (n = 95) and Friesian (n = 92).
Data suggest that activation of gammadelta T cells to IFN-gamma production, NK cell-like killing plays a pivotal role in controlling virus infection.
The differential expression levels of IFN-gamma mRNA between cattle and buffalo could be due to a conserved 4 base (GTCT) deletion in the promoter region of buffalo.
SNPs in IFNG, IFNGR1 (show IFNGR1 Proteins) and R2, IL22 (show IL22 Proteins), and IL22RA1 (show IL22RA1 Proteins) were analyzed for an association to Estimated breeding values for somatic cell score in Canadian Holstein bulls; no significant associations were found.
Nuclear localization sequence of bovine gamma-interferon provides translocation of recombinant protein to yeast Pichia pastoris cell nucleus
These results indicate that in equine corpus luteum, cytokines TNF (show TNF Proteins), IFNG and FASL (show FASL Proteins) regulate nitric oxide activity, via eNOS (show NOS3 Proteins) expression modulation.
IFN-gamma expression in foals appears to be controlled by DNA methylation (show HELLS Proteins) in the promoter region of Ifng. The age-associated demethylation of the DNA in foals may be induced by exposure to environmental antigens and their effect on lymphoproliferation (show FAS Proteins).
These data show the presence of cytokines TNF (show TNF Proteins) and IFNG, and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L Proteins) biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 (show IL10 Proteins) production by T cells is mature.
IFNgamma expression in colonic epithelial cells was regulated by TGFB1 (show TGFB1 Proteins).
Higher KIR2DL4 copy numbers is associated with an increased IFN-gamma production in NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
Data show that viral set-point in simian immunodeficiency virus diseasewas is associated with expression of interferon gamma -stimulated genes.
Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine interferon-gamma.
CD3 (show CD3 Proteins)(-) CD8 (show CD8A Proteins)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma, and that IL-15 (show IL15 Proteins) elicits IFN-gamma production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15 (show IL15 Proteins), CD8 (show CD8A Proteins) antigen, IFN-gamma]
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.
, gamma interferon
, interferon, gamma
, interferon gamma
, immune interferon
, interferon gamma type 2
, Interferon gamma
, IFN gamma