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Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN1305087
Farrar, Schreiber: The molecular cell biology of interferon-gamma and its receptor. in Annual review of immunology 1993
Show all 3 Pubmed References
Rat (Rattus) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN1305089
Gray, Goeddel: Cloning and expression of murine immune interferon cDNA. in Proceedings of the National Academy of Sciences of the United States of America 1983
Show all 2 Pubmed References
Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN803857
Shiraki, Ishibashi, Hiruma, Nishikawa, Ikeda: Candida albicans abrogates the expression of interferon-gamma-inducible protein-10 in human keratinocytes. in FEMS immunology and medical microbiology 2008
Show all 2 Pubmed References
Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN935524
POGO, BRAWERMAN, CHARGAFF: New ribonucleic acid species associated wihin the formation of the photosynthetic apparatus in Euglena gracilis. in Biochemistry 1970
Human IFNG Protein expressed in HEK-293 Cells - ABIN2181249
Derynck, Leung, Gray, Goeddel: Human interferon gamma is encoded by a single class of mRNA. in Nucleic acids research 1982
Show all 3 Pubmed References
Human IFNG Protein expressed in CHO Cells - ABIN2648879
Razaghi, Villacrés, Jung, Mashkour, Butler, Owens, Heimann: Improved therapeutic efficacy of mammalian expressed-recombinant interferon gamma against ovarian cancer cells. in Experimental cell research 2017
Mouse (Murine) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN413386
Kajiwara, Schiff, Voloudakis, Gama Sosa, Elder, Bozdagi, Buxbaum: A critical role for human caspase-4 in endotoxin sensitivity. in Journal of immunology (Baltimore, Md. : 1950) 2014
an enhanced expression of PD-L1 (show CD274 Proteins) was observed besides an increased production of IFN-gamma by TH2 cells.
The opposing roles of G-CSF (show CSF3 Proteins) and IFNgamma in regulation of innate inflammatory responses in a murine viral encephalitis model reveal G-CSF (show CSF3 Proteins) as a potential therapeutic target.
Phosphorylation of T-bet by RSK2 (show RPS6KA3 Proteins) is required for IFNgamma expression for attenuation of colon cancer metastasis and growth.
SNX8 (show SNX8 Proteins) mediates IFNG-triggered non-canonical signaling pathway and host defense against Listeria monocytogenes.
The complex role of IFN-gamma in autoimmunity and cholangitis.IFN-gamma induces IL-30 production which suppresses IFN-gamma mediated liver inflammation.
we confirmed that Th1 (show HAND1 Proteins) cell-conditioned medium decreased Cx43 (show GJA1 Proteins) protein levels in mixed glial cell cultures. These findings suggest that Th1 (show HAND1 Proteins) cell-derived IFNg activates microglia to release IL-1b (show IL1B Proteins) that reduces Cx43 (show GJA1 Proteins) gap junctions in astrocytes. Thus, Th1 (show HAND1 Proteins)-dominant inflammatory states disrupt astrocytic intercellular communication and may exacerbate multiple sclerosis.
this study shows that IFN-gamma promotes transendothelial migration of CD4 (show CD4 Proteins)(+) T cells across the blood-brain barrier
Addition of a disintegrin and metallopeptidase domain 17 (ADAM17 (show ADAM17 Proteins)) to the culture supernatant of stimulated splenocytes decreased Interferon-gamma (IFN-gamma) concentration.
a significant increase in plasma levels of IL-2 (show IL2 Proteins), IFN-g and TNF (show TNF Proteins)-g was revealed as assessed by ELISA. In conclusion, the results of the present study indicate that MENK has a cytotoxic effect on B16 melanoma cells in vitro and in vivo, and suggest a potential mechanism for these bioactivities.
this study shows that activation of IRF3 (show IRF3 Proteins) contributes to IFN-gamma and ISG54 (show IFIT2 Proteins) expression during the immune responses to B16F10 tumor growth
Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 (show IL4 Proteins) ratio were significantly lower than those exposed to its low concentration.
this study shows the age-related reductions in serum and PBMC IFN-gamma in healthy nonobese subjects
the frequencies of IFNgamma and IL-17A (show IL17A Proteins)(+) cells were increased in the antrum, particularly in patients with H. pylori induced gastric ulcers.
rs2069718 in the IFNG gene was significantly associated with pulmonary tuberculosis but not spinal tuberculosis.
IFN-gamma was associated with a cerebral volume reduction in systemic lupus erythematosus with central nervous system involvement
Data suggest that semen exhibits substantial individual variation over time in pro-inflammatory seminal fluid cytokines IFNG and CXCL8 (show IL8 Proteins). (IFNG = interferon gamma; CXCL8 (show IL8 Proteins) = C-X-C motif chemokine ligand 8 (show CCL8 Proteins))
Dysregulation of the IFN-gamma-STAT1 (show STAT1 Proteins) signaling pathway in a cell line model of large granular lymphocyte leukemia
STAT1b plays a key role in enhancing the tumor suppressor function of STAT1a, in ESCC, in a manner that can be amplified by IFN-gamma
epigenetic silencing by single CpG methylation determines differential IL18BP (show IL18BP Proteins) inducibility in monocytic versus epithelial cells. T
The regulatory effect of IFN-gamma on CYP3A29 expression is mediated via PXR (show NR1I2 Proteins).
Translational control of IL-18 (show IL18 Proteins) expression by its 5'-UTR limits production of IL-18 (show IL18 Proteins), resulting in restricted expression of mRNA and protein IFN-gamma in this model of crescentic glomerulonephritis(GN). Might amplify CD8 (show CD8A Proteins)+-mediated macrophage-dependent GN.
selective changes in immature crypt cells induced by IFN-gamma bound to extracellular matrix could contribute to inappropriate responsiveness to commensal bacteria in inflammatory bowel diseases
A functional single nucleotide polymorphism is reported in the coding region of IFN-gamma cDNA that markedly reduces antiviral activity of the IFN-gamma protein.
The expression of IFN-gamma in recombiannt Lactococcus lactis as a tool for investigating downregulation of allergic predisposition of pigs to experimental food allergy is reported.
The expression of multiple toll (show TLR4 Proteins)-like receptors, interferon-gamma, and interleukin-12 (IL-12 (show IL12A Proteins)) in cattle with low and high proviral loads of bovine leukemia virus are reported.
Diet-driven interferon-gamma enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy.
Data suggest that luteolytic factors (such as IFNG, tumor necrosis factor alpha (show TNF Proteins), and PGF2a) control expression of MMP1 (show MMP1 Proteins), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These findings indicate that IFN-gamma production correlates negatively and the production of antibodies against N. caninum is uncorrelated with plasma pregnancy-associated glycoproteins levels.
These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma occurring after parturition and an increase in IL-4 (show IL4 Proteins) production before calving.
Genetic characterization of IFNG gene was done in resistant and susceptible animals of Sahiwal cattle (n = 95) and Friesian (n = 92).
Data suggest that activation of gammadelta T cells to IFN-gamma production, NK cell-like killing plays a pivotal role in controlling virus infection.
The differential expression levels of IFN-gamma mRNA between cattle and buffalo could be due to a conserved 4 base (GTCT) deletion in the promoter region of buffalo.
SNPs in IFNG, IFNGR1 (show IFNGR1 Proteins) and R2, IL22 (show IL22 Proteins), and IL22RA1 (show IL22RA1 Proteins) were analyzed for an association to Estimated breeding values for somatic cell score in Canadian Holstein bulls; no significant associations were found.
Nuclear localization sequence of bovine gamma-interferon provides translocation of recombinant protein to yeast Pichia pastoris cell nucleus
These results indicate that in equine corpus luteum, cytokines TNF (show TNF Proteins), IFNG and FASL (show FASL Proteins) regulate nitric oxide activity, via eNOS (show NOS3 Proteins) expression modulation.
IFN-gamma expression in foals appears to be controlled by DNA methylation (show HELLS Proteins) in the promoter region of Ifng. The age-associated demethylation of the DNA in foals may be induced by exposure to environmental antigens and their effect on lymphoproliferation (show FAS Proteins).
These data show the presence of cytokines TNF (show TNF Proteins) and IFNG, and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L Proteins) biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 (show IL10 Proteins) production by T cells is mature.
IFNgamma expression in colonic epithelial cells was regulated by TGFB1 (show TGFB1 Proteins).
Higher KIR2DL4 copy numbers is associated with an increased IFN-gamma production in NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
Data show that viral set-point in simian immunodeficiency virus diseasewas is associated with expression of interferon gamma -stimulated genes.
Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine interferon-gamma.
CD3 (show CD3 Proteins)(-) CD8 (show CD8A Proteins)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma, and that IL-15 (show IL15 Proteins) elicits IFN-gamma production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15 (show IL15 Proteins), CD8 (show CD8A Proteins) antigen, IFN-gamma]
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.
, gamma interferon
, interferon, gamma
, interferon gamma
, immune interferon
, interferon gamma type 2
, Interferon gamma
, IFN gamma