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Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN1305087
Farrar, Schreiber: The molecular cell biology of interferon-gamma and its receptor. in Annual review of immunology 1993
Show all 3 Pubmed References
Rat (Rattus) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN1305089
Gray, Goeddel: Cloning and expression of murine immune interferon cDNA. in Proceedings of the National Academy of Sciences of the United States of America 1983
Show all 2 Pubmed References
Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN803857
Shiraki, Ishibashi, Hiruma, Nishikawa, Ikeda: Candida albicans abrogates the expression of interferon-gamma-inducible protein-10 in human keratinocytes. in FEMS immunology and medical microbiology 2008
Show all 2 Pubmed References
Human IFNG Protein expressed in Escherichia coli (E. coli) - ABIN935524
POGO, BRAWERMAN, CHARGAFF: New ribonucleic acid species associated wihin the formation of the photosynthetic apparatus in Euglena gracilis. in Biochemistry 1970
Human IFNG Protein expressed in HEK-293 Cells - ABIN2181249
Derynck, Leung, Gray, Goeddel: Human interferon gamma is encoded by a single class of mRNA. in Nucleic acids research 1982
Show all 3 Pubmed References
Human IFNG Protein expressed in CHO Cells - ABIN2648879
Razaghi, Villacrés, Jung, Mashkour, Butler, Owens, Heimann: Improved therapeutic efficacy of mammalian expressed-recombinant interferon gamma against ovarian cancer cells. in Experimental cell research 2017
Mouse (Murine) IFNG Protein expressed in Escherichia coli (E. coli) - ABIN413386
Kajiwara, Schiff, Voloudakis, Gama Sosa, Elder, Bozdagi, Buxbaum: A critical role for human caspase-4 in endotoxin sensitivity. in Journal of immunology (Baltimore, Md. : 1950) 2014
The expression of CXCL10 (show CXCL10 Proteins) mRNA and IFN-gamma mRNA was significantly higher in non-lesional and perilesional skin of vitiligo (show MITF Proteins) and alopecia areata patients compared with the skin of healthy controls; however, the level of expression of CXCL10 (show CXCL10 Proteins) and IFN-gamma in lesional skin was not different than that in healthy skin
High IFNG expression is associated with Chronic Periodontitis.
hypomethylation of the IFNG promoter is significantly related to the risk of essential hypertension
These results demonstrated that the IFNGinduced immunosuppressive properties of B7H1 (show CD274 Proteins) in human BM and WJMSCs were mediated by STAT1 (show STAT1 Proteins) signaling, and not by PI3K (show PIK3CA Proteins)/RACalpha (show AKT1 Proteins) serine/threonineprotein kinase signaling
serum IP-10 (show CXCL10 Proteins) level and the IFN-gamma/IL-4 (show IL4 Proteins) ratio have great potential to predict significant fibrosis among chronic hepatitis B patients.
IFN-gamma increases free ISG15 (show ISG15 Proteins) levels in the cytoplasm and ISGylation in the nucleus and cytoplasm, but in a manner distinct between MCF-7 and MDA-MB-231cells.
the expression of IFN-gamma and IL-17 (show IL17A Proteins) was also suppressed by IRAK1 (show IRAK1 Proteins)/4 inhibitor both in active Behcet's patients and in normal subjects.
Results provide evidence that rs2069707 locus SNPs of IFN-gamma is a risk factor for contracting tuberculous pericarditis.
No correlation was observed between interferon gamma mRNA/protein levels and recurrent depressive disorders.
Aberrant IFN-gamma promoter methylation may be involved in the process of tumorigenesis of oral cancer.
Data confirm Ifng as robust supporter of immune responses against tumors; here, mice treated with Chlorella vulgaris probiotic supposed as anti-carcinogen against mammary tumor, instead tumors in treated group exhibit more malignant phenotype and lower peri (show POSTN Proteins)-tumoral neutrophil and macrophage-to-lymphocyte infiltration ratio compared to control mice; decline in serum Ifng levels correlated with tumor growth.
In interferon gamma (IFNgamma)-deficient mice, Akkermansia muciniphila is significantly increased and restoration of IFNgamma levels reduces A. muciniphila abundance.
this study shows the positive effects of Ifng on the early-stage differentiation and negative effects on the calcification of primary osteoblasts in vitro
these data support the novel concept that IFN-gamma can have a detrimental role in the pathogenesis of influenza through a restriction in innate lymphoid cell group II activity
IFN-gamma-iNOS (show NOS2 Proteins) axis are an essential pathway in the pathogenesis of arenavirus hemorrhagic fever.
IFN-gamma can promote cancer immunoevasion. (Review)
Study shows that circulating interferon (show IFNA Proteins)- that binds to receptors on brain endothelial cells and induces Cxcl10 (show CXCL10 Proteins), is a central link in the signaling chain eliciting inflammation-induced aversion.
IRF-1 (show IRF1 Proteins) may be at the nexus of the interplay between IFN-gamma and IL-6 (show IL6 Proteins) in exacerbating a xenobiotic-induced inflammatory response, regulation of interferon (show IFNA Proteins) responsive genes and autoimmunity
an enhanced expression of PD-L1 (show CD274 Proteins) was observed besides an increased production of IFN-gamma by TH2 cells.
The opposing roles of G-CSF (show CSF3 Proteins) and IFNgamma in regulation of innate inflammatory responses in a murine viral encephalitis model reveal G-CSF (show CSF3 Proteins) as a potential therapeutic target.
The regulatory effect of IFN-gamma on CYP3A29 expression is mediated via PXR (show NR1I2 Proteins).
Translational control of IL-18 (show IL18 Proteins) expression by its 5'-UTR limits production of IL-18 (show IL18 Proteins), resulting in restricted expression of mRNA and protein IFN-gamma in this model of crescentic glomerulonephritis(GN). Might amplify CD8 (show CD8A Proteins)+-mediated macrophage-dependent GN.
selective changes in immature crypt cells induced by IFN-gamma bound to extracellular matrix could contribute to inappropriate responsiveness to commensal bacteria in inflammatory bowel diseases
A functional single nucleotide polymorphism is reported in the coding region of IFN-gamma cDNA that markedly reduces antiviral activity of the IFN-gamma protein.
The expression of IFN-gamma in recombiannt Lactococcus lactis as a tool for investigating downregulation of allergic predisposition of pigs to experimental food allergy is reported.
CD3 (show CD3 Proteins)(-) CD8 (show CD8A Proteins)(+) NK cells play a vital role in controlling HIV-1 infection by producing high levels of IFN-gamma, and that IL-15 (show IL15 Proteins) elicits IFN-gamma production in this subpopulation of NK cells in HIV-1-infected chimpanzees. [Il-15 (show IL15 Proteins), CD8 (show CD8A Proteins) antigen, IFN-gamma]
The expression of multiple toll (show TLR4 Proteins)-like receptors, interferon-gamma, and interleukin-12 (IL-12 (show IL12A Proteins)) in cattle with low and high proviral loads of bovine leukemia virus are reported.
Diet-driven interferon-gamma enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy.
Data suggest that luteolytic factors (such as IFNG, tumor necrosis factor alpha (show TNF Proteins), and PGF2a) control expression of MMP1 (show MMP1 Proteins), other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
These findings indicate that IFN-gamma production correlates negatively and the production of antibodies against N. caninum is uncorrelated with plasma pregnancy-associated glycoproteins levels.
These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma occurring after parturition and an increase in IL-4 (show IL4 Proteins) production before calving.
Genetic characterization of IFNG gene was done in resistant and susceptible animals of Sahiwal cattle (n = 95) and Friesian (n = 92).
Data suggest that activation of gammadelta T cells to IFN-gamma production, NK cell-like killing plays a pivotal role in controlling virus infection.
The differential expression levels of IFN-gamma mRNA between cattle and buffalo could be due to a conserved 4 base (GTCT) deletion in the promoter region of buffalo.
SNPs in IFNG, IFNGR1 (show IFNGR1 Proteins) and R2, IL22 (show IL22 Proteins), and IL22RA1 (show IL22RA1 Proteins) were analyzed for an association to Estimated breeding values for somatic cell score in Canadian Holstein bulls; no significant associations were found.
Nuclear localization sequence of bovine gamma-interferon provides translocation of recombinant protein to yeast Pichia pastoris cell nucleus
These results indicate that in equine corpus luteum, cytokines TNF (show TNF Proteins), IFNG and FASL (show FASL Proteins) regulate nitric oxide activity, via eNOS (show NOS3 Proteins) expression modulation.
IFN-gamma expression in foals appears to be controlled by DNA methylation (show HELLS Proteins) in the promoter region of Ifng. The age-associated demethylation of the DNA in foals may be induced by exposure to environmental antigens and their effect on lymphoproliferation (show FAS Proteins).
These data show the presence of cytokines TNF (show TNF Proteins) and IFNG, and their receptors, in the equine corpus luteum and indicate their potential involvement in regulation of luteal function.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L Proteins) biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 (show IL10 Proteins) production by T cells is mature.
Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 (show IL4 Proteins) ratio were significantly lower than those exposed to its low concentration.
IFNgamma expression in colonic epithelial cells was regulated by TGFB1 (show TGFB1 Proteins).
Higher KIR2DL4 copy numbers is associated with an increased IFN-gamma production in NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
Data show that viral set-point in simian immunodeficiency virus diseasewas is associated with expression of interferon gamma -stimulated genes.
Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine interferon-gamma.
The zfIFN-gamma monoclonal antibody specifically recognises E. coli produced recombinant IFN-gamma protein and zfIFN-gamma produced in transfected HEK293 cells, by Western blot analysis. IFN-gamma protein is produced as a dimer, and a good correlation exists between transcript expression levels and protein levels.
There are two IFN-gamma-like genes are present in tandem, 7.0 kb apart from each other, in the zebrafish genome.
IFN-gamma signaling acts cell autonomously to control the endothelial-to-hematopoietic stem cell transition
Conditions are identified in which Ifn-gamma1 and Ifn-gamma2 are induced in fish larvae and adults; the receptor complex for Ifn-gamma2 includes cytokine receptor (show LEPR Proteins) family B (Crfb)6 together with Crfb13 and Crfb17 (show IFNGR1 Proteins).
zebrafish IFN-gamma1 and IFN-gamma2 are functionally equivalent to mammalian IFN-gamma
Evidence is provided for a pivotal role of group II interferon (show IFNA Proteins) of zebrafish in the early stages of viral infections, whereas group I interferons exert a slow but more powerful induction of several antiviral and proinflammatory genes.
the identification of a novel isoform of the zebrafish (Danio rerio) IFNGR1 (show IFNGR1 Proteins) is reported.
This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.
, immune interferon
, interferon gamma
, gamma interferon
, IFN gamma
, interferon gamma type 2
, interferon, gamma
, Interferon gamma
, interferon alpha