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anti-Human IRF1 Antibodies:
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Human Monoclonal IRF1 Primary Antibody for ELISA, WB - ABIN561520
Baumjohann, Okada, Ansel: Cutting Edge: Distinct waves of BCL6 expression during T follicular helper cell development. in Journal of immunology (Baltimore, Md. : 1950) 2011
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Human Monoclonal IRF1 Primary Antibody for IF, WB - ABIN968725
Cha, Sims, Romine, Kaufmann, Deisseroth: Human interferon regulatory factor 1: intron-exon organization. in DNA and cell biology 1992
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Human Monoclonal IRF1 Primary Antibody for IF, WB - ABIN968724
Kröger, Ortmann, Krohne, Mohr, Blum, Hauser, Geissler: Growth suppression of the hepatocellular carcinoma cell line Hepa1-6 by an activatable interferon regulatory factor-1 in mice. in Cancer research 2001
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Following spring viremia of carp (show ANKRD1 Antibodies) virus infection, DrIFNPhi1/3 and DrIRF1/3/7 transcripts are significantly induced in zebrafish tissues, which correlates with the replication of spring viremia of carp (show ANKRD1 Antibodies) virus. data provide evidence that fish and mammals have evolved a similar IRF (show TRIM63 Antibodies)-dependent regulatory mechanism fine-tuning IFN gene activation.
Upregulation of IRF1 in human adipocytes leads to phenotypes associated with obesity-related inflammation.
Regulation of transcriptional activators by DNA-binding domain (DBD) ubiquitination has shown that, when attached to the DBD of either p53 or IRF-1, ubiquitin is orientated towards, and makes contact with, the DNA.
In SK-Hep1 cells, an increase in apoptosis and decrease in autophagy were observed after IFN-gamma (show IFNG Antibodies) stimulation, which was accompanied with increasing IRF-1 levels.
HNP1 (show DEFA1 Antibodies) upregulation of cytokine expression in pDCs was inhibited by blockade of NF-kappaB (show NFKB1 Antibodies) activation or knockdown of IRF1, demonstrating the importance of these two signaling events in HNP1 (show DEFA1 Antibodies)-induced pDC (show PNKD Antibodies) activation.
Data show that the Japanese encephalitis virus (JEV)-induced expression of miR (show MLXIP Antibodies)-301a led to inhibition of the production of the transcription factor IFN regulatory factor 1 (IRF1) and the signaling protein suppressor of cytokine signaling 5 (SOCS5 (show SOCS5 Antibodies)).
A comprehensive mass spectrometric analysis identified interferon regulatory factor 1 (IRF1) as a key transcription factor in growth arrest of LNCaP-mTOR (show FRAP1 Antibodies).
IFN regulatory factor 1 effectively inhibits hepatitis E virus replication through the activation of the JAK (show JAK3 Antibodies)-STAT (show STAT1 Antibodies) pathway
B. abortus lipoproteins via IL-6 (show IL6 Antibodies) inhibit the expression of IFN regulatory factor 1 (IRF-1), a critical regulatory transcription factor for CIITA (show CIITA Antibodies) induction.
STAT1 (show STAT1 Antibodies) and IRF1 collaborate to induce interferon-gamma (show IFNG Antibodies) stimulated genes (ISGs), but the extent to which they act alone or together is unclear.This study provides strong evidence for widespread cooperation between STAT1 (show STAT1 Antibodies) and IRF1 at ISGs, and suggests that in silico predictions reliably predict the effect of nucleotide variants on binding in vivo.
aimed to determine the role of Treg cells and IRF-1 in MDS (show PAFAH1B1 Antibodies)
Given these results, porcine IRF1 plays potential roles in cellular antiviral responses against swine viruses.
In a healthy swine model, elevated levels of endothelial IRF-1 were also observed within atherosusceptible regions of the aorta by Western blot analysis and immunohistochemistry, implicating arterial hemodynamics in the regulation of IRF-1 expression.
The results suggested that the porcine IRF1 gene is strong candidate gene for these immune traits in pig.
IRF-1 plays a key role in controlling caspase-1 (show CASP1 Antibodies)-dependent pyroptosis and inflammation.
Results indicate IRF-1 is one of the key transcriptional factors for the prevention of neointimal formation involving angiotensin II type 2 receptors.
Data show that HCFC2 (show HCFC2 Antibodies) is a critical component of the IRF1 and IRF2 (show IRF2 Antibodies) transcriptional machinery that regulates Tlr3 (show TLR3 Antibodies) gene expression.
Our studies uncovered the critical role of two transcription factors, IRF1 and BATF, in preparing the chromatin landscape for induction of the Tr1 (show TXNRD1 Antibodies) gene network in response to IL-27 (show IL27 Antibodies) signaling, where BATF acted as a pioneer factor and prepared the genomic landscape for the binding of additional transcription factors that define the Tr1 (show TXNRD1 Antibodies) lineage.
IRF-1 and interferon-alpha (show IFNA Antibodies) with interferon-beta (show IFNB1 Antibodies) cooperate to control acute gammaherpesvirus infection.
this study shows that binding motifs for the transcription factors STAT1 (show STAT1 Antibodies) and IRF1 are associated with robust and IL-4 (show IL4 Antibodies)-resistant responses to IFN-gamma (show IFNG Antibodies) in macrophages
5AZ had a protective effect after MI by potentiation of IRF1 sumoylation and is suggested as a novel therapeutic intervention for cardiac repair.
direct the expression of a set of genes, the IRF8 (show IRF8 Antibodies)/IRF1 regulome, that play critical roles in host inflammatory and antimicrobial defenses in mouse models of neuroinflammation and of pulmonary tuberculosis, respectively
couples synthesis of miR (show MLXIP Antibodies)-342-5p to the antiviral interferon (show IFNA Antibodies) response
IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion.
interferon regulatory factor 1
, interferon regulatory factor 11
, interferon responsive factor 1