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anti-Human FOXA1 Antibodies:
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Human Monoclonal FOXA1 Primary Antibody for IHC (p), RNAi - ABIN561299
Bretschneider, Brand, Miller, Lowery, Kerin, Gannon, Denger: Estrogen induces repression of the breast cancer and salivary gland expression gene in an estrogen receptor alpha-dependent manner. in Cancer research 2008
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Human Polyclonal FOXA1 Primary Antibody for ELISA, WB - ABIN547099
Carroll, Liu, Brodsky, Li, Meyer, Szary, Eeckhoute, Shao, Hestermann, Geistlinger, Fox, Silver, Brown: Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. in Cell 2005
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Human Monoclonal FOXA1 Primary Antibody for ChIPSeq, ChIP - ABIN2668682
Nucera, Eeckhoute, Finn, Carroll, Ligon, Priolo, Fadda, Toner, Sheils, Attard, Pontecorvi, Nose, Loda, Brown: FOXA1 is a potential oncogene in anaplastic thyroid carcinoma. in Clinical cancer research : an official journal of the American Association for Cancer Research 2009
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Human Polyclonal FOXA1 Primary Antibody for ChIP, IHC (p) - ABIN249930
Lin, Miller, Contreras, Prescott, Dagenais, Wu, Yee, Orringer, Misek, Hanash, Glover, Beer: The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas. in Cancer research 2002
Cow (Bovine) Polyclonal FOXA1 Primary Antibody for WB - ABIN2780597
Lupien, Eeckhoute, Meyer, Wang, Zhang, Li, Carroll, Liu, Brown: FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. in Cell 2008
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a compact palindromic DNA element (termed 'DIV' for its diverging half-sites) induces the homodimerization of FOXA1 with strongly positive cooperativity. Collectively, the DIV guides chromatin engagement and regulation by FOXA1 and its perturbation could be linked to disease etiologies.
the functional genetic variant rs4442975 (FOXA1)was associated with bone marrow suppression during neoadjuvant chemotherapy for luminal A type breast cancer. These results may help establish reliable molecular markers for predicting the prognosis of personalized treatment for luminal A type breast cancer and thereby contribute to the development of appropriate therapies.
CK7 expression is an independent prognostic factor for esophageal squamous cell carcinoma, and FOXA1 is a non-independent prognostic factor.
FOXA1 was expressed mostly in ER-positive breast cancer metastases. Expression of Nestin was related to triple-negative metastases, where brain was the most frequent metastatic site. These findings highlight the clinical utility of FOXA1 and Nestin expression and warrant their inclusion in routine immunohistochemical panels for breast carcinoma.
Circular RNA MCM3AP-AS1 directly bound to miR-194-5p and acted as competing endogenous RNA while subsequently facilitating miR-194-5p target gene FOXA1 expression in hepatocellular carcinoma cells.
Here we identify the transcription factor ONECUT2 (OC2) as a master regulator of AR networks in metastatic castration-resistant prostate cancer (mCRPC). OC2 acts as a survival factor in mCRPC models, suppresses the AR transcriptional program by direct regulation of AR target genes and the AR licensing factor FOXA1, and activates genes associated with neural differentiation and progression to lethal disease.
the expression level of miR-132 was decreased in thyroid cancer tissues and cell lines and that miR-132 inhibited cell proliferation, migration, and invasion of thyroid cancer by repressing FOXA1.
these results provide a mechanism for how interdependent FoxO1:FoxA1/2 binding is negatively impacted by insulin and provide a developmental context for cooperative gene activation by these factors.
Mammary Paget's disease and extramammary (EMPD) share dysregulation of the glandular developmental regulator gene FOXA1
FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer.
We show that MSK1 downregulation impairs the differentiation of breast cancer cells, increasing their bone homing and growth capacities. MSK1 controls the expression of genes required for luminal cell differentiation, including the GATA3 and FOXA1 transcription factors, by modulating their promoter chromatin status.
The cell cycle control kinase CDK1 might control directly FOXA1 by phosphorylation and other kinases indirectly by means of regulating other proteins.
The unexpected signature for estradiol-induced program resides in indirect recruitment of ERa to a large cohort of basally active FOXA1-bound enhancers that lack cognate ERa DNA-binding elements.
In salivary duct carcinoma, FOXA1, which may biologically interact with the AR and PI3K signalling pathways, is a putative biomarker that may be associated with a favourable prognosis.
FOXA1 has a role in prostate cancer cells; its knock-out via CRISPR/Cas9 alters Casp-9, Bax, CCND1, CDK4, and fibronectin expressions in LNCaP cells
LINC00460 promotes LC progression by competitively binding miR-302c-5p and regulating FOXA1 signal pathway.
High FOXA1 expression is associated with the pathogenesis of gastric cancer.
FoxA1 might be related to the development and differentiation of secretory coil-like structures, as well as the secretory function of the 3D reconstructed eccrine sweat glands.
TUG1 promoted osteosarcoma cell proliferation and suppressed apoptosis by regulating the miR-212-3p/FOXA1 axis.
miR-760 should be considered as a tumor suppressor since it negatively regulates the oncogene protein FOXA1 and regulated TRAIL sensitivity in Non-small cell lung cancer cells.
we propose a model in which deletion of Foxa1 from STN neurons evokes a compromised state of the STN, evident by the reduced firing activity of STN neurons and the loss of a significant fraction of STN neurons.
this model system will facilitate further in vivo functional studies of Foxa1 or other factors in mammary gland development and tumor formation and progression
Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin-sensitive Genes.
FoxA1, FoxA2, and LIPG control the uptake of extracellular lipids for breast cancer growth.
genome-wide binding sites of the forkhead/winged helix transcription factor Foxa1, which functions redundantly with Foxa2 to regulate the differentiation of midbrain dopamine neurons, were characterized.
Disruption of Shp in mice alters timing of expression of genes that regulate homocysteine metabolism and the liver responses to ethanol and homocysteine. SHP inhibits the transcriptional activation of Bhmt and cystathionine gamma-lyase by FOXA1.
ChIP-exonuclease of the ER pioneer factor FoxA1 identifies protected DNA with a predictable 8 bp overhang from the Forkhead motif, which authors term mesas; showed that mesas occur in multiple cellular contexts and exist as single or overlapping motifs.
TIP30 is a key regulator for maintaining ER(+) and ER(-)luminal pools in the mammary luminal lineage via FoxA1.
Mechanistically, JARID1B was required for GATA3 recruitment to the Foxa1 promoter to activate Foxa1 expression.
Foxa1 recruited Grg3 to the Nanog promoter -2kb upstream region and switched the promoter to an inactive chromatin status represented by typical modifications in histone H3.
Results indicate Foxa1 expression is required for the maintenance of prostatic cellular differentiation.
FoxA1 is a lineage-specification factor that is induced by IFN-beta and supports the differentiation and suppressive function of FoxA1(+) Treg cells
Results suggest that the downregulation of miR-17 expression could lead to FoxA1 overexpression in acute lung injury (ALI).
FoxA1 defines prostate-specific androgen receptor recruitment. It is constitutively bound to chromatin and guides AR to specific genomic loci upon hormone exposure.
Foxa1 and Foxa2 are required for formation of the intervertebral discs.
This study demonistrated that the later role for Foxa genes in regulating the maintenance of dopaminergic phenotype in mDA neurons.
Foxa1 and Foxa2, while redundant during development, have evolved divergent roles in the adult liver, ensuring the maintenance of both genes during evolution.
Stable expression of FoxA1 promotes pluripotent P19 embryonal carcinoma cells to be neural stem-like cells.
FOXA1 is direct transcriptional inhibitor of SLUG expression in prostate cancer cells and play a key role in epithelial-mesenchymal transition
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
, forkhead box protein A1
, hepatocyte nuclear factor 3-alpha
, transcription factor 3A
, fork head domain
, hepatocyte nuclear factor 3 alpha (winged helix transcription factor)
, hepatocyte nuclear factor 3, alpha
, fork head domain protein 7
, HNF-3 alpha
, HNF3 alpha
, HNF3alpha homolog B
, fork head domain-related protein 7'
, forkhead box protein A1-B
, forkhead protein 2
, hepatocyte nuclear factor 3-alpha homolog B
, forkhead transcription factor FoxA1
, forkhead homolog
, hepatocyte nuclear factor 3 alpha
, forkhead box A1
, hepatocyte nuclear factor 3-alpha-like