FOXA1 antibody (AA 367-472)

Catalog No. ABIN561299

There are 4+ publications for this product available. The Mouse Monoclonal anti-FOXA1 antibody is suitable to detect FOXA1 in samples from Human. It has been validated for WB, ELISA, IHC (p) and RNAi.

Quick Overview for FOXA1 antibody (AA 367-472) (ABIN561299)

Target: FOXA1 (Forkhead Box A1 (FOXA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FOXA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), RNA Interference (RNAi)

Clone: 2D7

Product Details anti-FOXA1 Antibody

Binding Specificity: AA 367-472

Purpose: Mouse monoclonal antibody raised against a partial recombinant FOXA1.

Sequence: LASVPASHPA HGLAPHESQL HLKGDPHYSF NHPFSINNLM SSSEQQHKLD FKAYEQALQY SPYGSTLPAS LPLGSASVTT RSPIEPSALE PAYYQGVYSR PVLNTS

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: FOXA1 (NP_004487, 367 a.a. ~ 472 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-FOXA1 antibody (ABIN561299)

Kobayashi, Iwaya, Moriya, Yamasaki, Tsuda, Yamamoto, Matsubara: "A simple immunohistochemical panel comprising 2 conventional markers, Ki67 and p53, is a powerful tool for predicting patient outcome in luminal-type breast cancer." in: BMC clinical pathology, Vol. 13, pp. 5, (2013) (PubMed).

Braun, Mietzsch, Seibold, Schneeweiss, Schirmacher, Chang-Claude, Peter Sinn, Aulmann: "Intrinsic breast cancer subtypes defined by estrogen receptor signalling-prognostic relevance of progesterone receptor loss." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 26, Issue 9, pp. 1161-71, (2013) (PubMed).

Jacquemier, Charafe-Jauffret, Monville, Esterni, Extra, Houvenaeghel, Xerri, Bertucci, Birnbaum: "Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer." in: Breast cancer research : BCR, Vol. 11, Issue 2, pp. R23, (2009) (PubMed).

Bretschneider, Brand, Miller, Lowery, Kerin, Gannon, Denger: "Estrogen induces repression of the breast cancer and salivary gland expression gene in an estrogen receptor alpha-dependent manner." in: Cancer research, Vol. 68, Issue 1, pp. 106-14, (2008) (PubMed).

Target Details for FOXA1

Target: FOXA1 (Forkhead Box A1 (FOXA1))

Alternative Name: FOXA1

Background: Full Gene Name: forkhead box A1
Synonyms: HNF3A,MGC33105,TCF3A

Gene ID: 3169

NCBI Accession: NM_004496

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis